Abstract:
:We perceive motion when presented with spatiotemporal changes in contrast (second-order cue). This requires linear signals to be rectified and then summed in temporal order to compute direction. Although both operations have been attributed to cortex, rectification might occur in retina, prior to the ganglion cell. Here we show that the Y ganglion cell does indeed respond to spatiotemporal contrast modulations of a second-order motion stimulus. Responses in an OFF ganglion cell are caused by an EPSP/IPSP sequence evoked from within the dendritic field; in ON cells inhibition is indirect. Inhibitory effects, which are blocked by tetrodotoxin, clamp the response near resting potential thus preventing saturation. Apparently the computation for second-order motion can be initiated by Y cells and completed by cortical cells that sum outputs of multiple Y cells in a directionally selective manner.
journal_name
Neuronjournal_title
Neuronauthors
Demb JB,Zaghloul K,Sterling Pdoi
10.1016/s0896-6273(01)00484-6subject
Has Abstractpub_date
2001-11-20 00:00:00pages
711-21issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(01)00484-6journal_volume
32pub_type
杂志文章相关文献
NEURON文献大全abstract::Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Aβ₄₂ are established biomarkers for Alzheimer's disease (AD) and have been used as quantitative traits for genetic analyses. We performed the largest genome-wide association study for cerebrospinal fluid (CSF) tau/ptau levels published to d...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.02.026
更新日期:2013-04-24 00:00:00
abstract::Diagnoses of behavioral disorders such as autism spectrum disorder and schizophrenia are based on symptomatic descriptions that have been difficult to connect to mechanism. Although psychiatric genetics provide insight into the genetic underpinning of such disorders, with a majority of cases explained by polygenic fac...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.03.021
更新日期:2018-04-18 00:00:00
abstract::Seizure causes a rapid and protracted increase in transcription factor AP-1 levels in the brain. The composition of AP-1 nucleoprotein complexes changes with time after seizure as a result of the sequential appearance and disappearance of Fos and several Fos-related proteins. Although these changes occur over an 8 hr ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90260-2
更新日期:1989-09-01 00:00:00
abstract::Statistical regularities in the environment create prior beliefs that we rely on to optimize our behavior when sensory information is uncertain. Bayesian theory formalizes how prior beliefs can be leveraged and has had a major impact on models of perception, sensorimotor function, and cognition. However, it is not kno...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.06.012
更新日期:2019-09-04 00:00:00
abstract::In this issue of Neuron, Holz et al. (2019) show that the synaptic protein Homer1a switches mGluR5 signaling to increase AMPA receptor activity for the rapid antidepressant actions of sleep deprivation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.10.003
更新日期:2019-10-23 00:00:00
abstract::Certain neurons in the mammalian brain have long been known to be joined by gap junctions, which are the most common type of electrical synapse. More recently, cloning of neuron-specific connexins, increased capability of visualizing cells within brain tissue, labeling of cell types by transgenic methods, and generati...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(04)00043-1
更新日期:2004-02-19 00:00:00
abstract::Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood. We show here that Notch and abl mutations interact synergistically to produce synthetic lethality and defects in axon extension. Surprisingly, we cannot...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81007-7
更新日期:1998-04-01 00:00:00
abstract::Cholinergic interneurons (CHIs) play a major role in motor and learning functions of the striatum. As acetylcholine does not directly evoke postsynaptic events at most striatal synapses, it remains unclear how postsynaptic cholinergic receptors encode the firing patterns of CHIs in the striatum. To examine the dynamic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.06.021
更新日期:2016-08-03 00:00:00
abstract::The primary visual cortex has a map of multiple visual parameters whose topographic relations remain poorly understood. A new study (Nauhaus et al., 2016) reveals a nearly geometric map-topography that coexists within a remarkably precise representation of visual space. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.08.001
更新日期:2016-08-17 00:00:00
abstract::How a single fertilized cell generates diverse neuronal populations has been a fundamental biological problem since the 19(th) century. Classical histological methods revealed that postmitotic neurons are produced in a precise temporal and spatial order from germinal cells lining the cerebral ventricles. In the 20(th)...
journal_title:Neuron
pub_type: 历史文章,杂志文章
doi:10.1016/j.neuron.2011.05.005
更新日期:2011-05-26 00:00:00
abstract::Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presy...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.09.003
更新日期:2006-09-21 00:00:00
abstract::Balance between excitation and inhibition (E-I balance) in neural circuits is believed to be tightly regulated. To the contrary, in this issue of Neuron, Bridi et al. (2020) reveal that inverse oscillations of synaptic inhibition and excitation lead to peaks and valleys in E-I balance across the 24 h day. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2020.01.035
更新日期:2020-02-19 00:00:00
abstract::Parkinson's disease (PD) is a common neurodegenerative disorder with no known cure. The etiology of PD is likely due, in part, to combinations of genetic susceptibilities and environmental factors. In rare familial cases, PD is due to genetic mutations. A number of new genetic and toxin models of PD and advances in ol...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(02)00780-8
更新日期:2002-07-18 00:00:00
abstract::The Drosophila circadian oscillator consists of interlocked period (per)/timeless (tim) and Clock (Clk) transcriptional/translational feedback loops. Within these feedback loops, CLK and CYCLE (CYC) activate per and tim transcription at the same time as they repress Clk transcription, thus controlling the opposite cyc...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00002-3
更新日期:2003-01-23 00:00:00
abstract::In this issue of Neuron, Moehle et al. (2017) demonstrate that presynaptic muscarinic receptors counteract the effects of dopamine in an output nucleus of the basal ganglia. They provide intracellular, anatomical, and network-level mechanisms for this cholinergic-dopaminergic interplay. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2017.12.014
更新日期:2017-12-20 00:00:00
abstract::Zika virus (ZIVK) represents a new threat to global health, with particular relevance to neuroscientists, due to associated newborn and adult neurological disease. Consequences of vertical infection include microcephaly with brain and eye anomalies, and consequences of adult infection include Guillain-Barré syndrome (...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2016.11.031
更新日期:2016-12-07 00:00:00
abstract::Neurotrophins and tyrosine receptor kinase (Trk) receptors are expressed in skeletal muscle, but it is unclear what functional role Trk-mediated signaling plays during postnatal life. Full-length TrkB (trkB.FL) as well as truncated TrkB (trkB.t1) were found to be localized primarily to the postsynaptic acetylcholine r...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81113-7
更新日期:1999-11-01 00:00:00
abstract::The apical tuft of layer 5 pyramidal neurons is innervated by a large number of inhibitory inputs with unknown functions. Here, we studied the functional consequences and underlying molecular mechanisms of apical inhibition on dendritic spike activity. Extracellular stimulation of layer 1, during blockade of glutamate...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.04.019
更新日期:2006-05-18 00:00:00
abstract::Embryonic retinal ganglion cell (RGC) axons must extend toward and grow through the optic disc to exit the eye into the optic nerve. In the embryonic mouse eye, we found that immunoreactivity for the axon guidance molecule netrin-1 was specifically on neuroepithelial cells at the disk surrounding exiting RGC axons, an...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80373-6
更新日期:1997-09-01 00:00:00
abstract::In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarchin...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2010.05.029
更新日期:2010-06-10 00:00:00
abstract::The discovery of SNCA mutations pathogenic for autosomal-dominant Lewy body Parkinson's disease (PD) in 1997 heralded a revolution in understanding the molecular and genetic basis of PD. Indeed, it now is clear that Lewy body PD is one of many neurodegenerative parkinsonian disorders that result from nigrostriatal deg...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.07.021
更新日期:2005-08-18 00:00:00
abstract::Primates with long-standing therapeutic amputations of a limb at a young age were used to investigate the possibility that deefferented motor nerves sprout to new muscle targets. Injections of anatomical tracers into the muscles proximal to the amputated stump labeled a larger extent of motoneurons than matched inject...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00167-7
更新日期:2000-12-01 00:00:00
abstract::We induced and characterized a recessive lethal mutation, nic-1, in zebrafish that blocks the function of muscle acetylcholine (ACh) receptors. Homozygous nic-1 embryos are nonmotile and fail to respond to exogenous application of cholinergic agonists, although their muscles contract in response to direct electrical s...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90139-7
更新日期:1990-06-01 00:00:00
abstract::Slob is a novel protein that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium (K(Ca)) channel. A yeast two-hybrid screen with Slob as bait identifies the zeta isoform of 14-3-3 as a Slob-binding protein. Coimmunoprecipitation experiments from Drosophila heads and trans...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80739-4
更新日期:1999-04-01 00:00:00
abstract::An autosomal recessive juvenile-onset form of Parkinson's disease (AR-JP) is caused by loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase. Three recent reports demonstrate that parkin can protect neurons from diverse cellular insults, including alpha-synuclein toxicity, proteasomal...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00201-0
更新日期:2003-04-10 00:00:00
abstract::Neuronal population responses can vary across trials as a result of differences in the relative timing of internal brain processes. In this issue of Neuron, Williams et al. (2020) present an algorithm for inferring and inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal st...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.12.010
更新日期:2020-01-22 00:00:00
abstract::Historically, the rat has been the preferred animal model for behavioral studies. Limitations in genome modification have, however, caused a lag in their use compared to the bevy of available transgenic mice. Here, we have developed several transgenic tools, including viral vectors and transgenic rats, for targeted ge...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.035
更新日期:2019-04-03 00:00:00
abstract::alpha-Latrotoxin is a potent stimulator of neurosecretion. Its action requires extracellular binding to high affinity presynaptic receptors. Neurexin I alpha was previously described as a high affinity alpha-latrotoxin receptor that binds the toxin only in the presence of calcium ions. Therefore, the interaction of al...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80332-3
更新日期:1997-06-01 00:00:00
abstract::Membrane excitability is a fundamentally important feature for all excitable cells including both neurons and muscle cells. However, the background depolarizing conductances in excitable cells, especially in muscle cells, are not well characterized. Although mutations in transmembrane channel-like (TMC) proteins TMC1 ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.12.041
更新日期:2018-02-07 00:00:00
abstract::In the precedence effect, sounds emanating directly from the source are localized preferentially over their reflections. Although most studies have focused on the delay between the onset of a sound and its echo, humans still experience the precedence effect when this onset delay is removed. We tested in barn owls the ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.07.014
更新日期:2010-08-26 00:00:00