Abstract:
:Parkinson's disease (PD) is a common neurodegenerative disorder with no known cure. The etiology of PD is likely due, in part, to combinations of genetic susceptibilities and environmental factors. In rare familial cases, PD is due to genetic mutations. A number of new genetic and toxin models of PD and advances in older models are yielding important new information about the pathogenesis of PD. This has prompted us to critically review the current animal models for PD and discuss how these models may yield fresh insights into the pathogenesis of PD, as well as new therapeutic opportunities.
journal_name
Neuronjournal_title
Neuronauthors
Dawson T,Mandir A,Lee Mdoi
10.1016/s0896-6273(02)00780-8subject
Has Abstractpub_date
2002-07-18 00:00:00pages
219-22issue
2eissn
0896-6273issn
1097-4199pii
S0896627302007808journal_volume
35pub_type
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