Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons.

abstract：:Metabotropic glutamate receptors (mGluRs) coupled to phosphoinositide hydrolysis desensitize in response to prolonged or repeated agonist exposure, and evidence suggests that this involves activation of protein kinase C (PKC). The present studies were undertaken to determine if cloned mGluR5 undergoes similar PKC-medi...

journal_title：Neuron

authors： Gereau RW 4th,Heinemann SF

更新日期：1998-01-01 00:00:00

abstract：:The Abl and Arg tyrosine kinases play fundamental roles in the development and function of the central nervous system. Arg is most abundant in adult mouse brain, especially in synapse-rich regions. arg(-/-) mice develop normally but exhibit multiple behavioral abnormalities, suggesting that arg(-/-) brains suffer from...

journal_title：Neuron

authors： Koleske AJ,Gifford AM,Scott ML,Nee M,Bronson RT,Miczek KA,Baltimore D

更新日期：1998-12-01 00:00:00

abstract：:The anterior insular cortex (AIC) and its unique spindle-shaped von Economo neuron (VEN) emerged within the last decade as having a potentially major role in self-awareness and social cognition in humans. Invasive examination of the VEN has been precluded so far by the assumption that this neuron occurs among primates...

journal_title：Neuron

authors： Evrard HC,Forro T,Logothetis NK

更新日期：2012-05-10 00:00:00

abstract：:In stable environments, decision makers can exploit their previously learned strategies for optimal outcomes, while exploration might lead to better options in unstable environments. Here, to investigate the cortical contributions to exploratory behavior, we analyzed single-neuron activity recorded from four different...

journal_title：Neuron

authors： Donahue CH,Seo H,Lee D

更新日期：2013-10-02 00:00:00

abstract：:Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem ce...

journal_title：Neuron

authors： Hanoun M,Maryanovich M,Arnal-Estapé A,Frenette PS

更新日期：2015-04-22 00:00:00

abstract：:The calcium-activated small conductance potassium channel SK3 plays an essential role in the regulation of dopamine neuron activity patterns. Here we demonstrate that expression of a human disease-related SK3 mutation (hSK3Δ) in dopamine neurons of mice disrupts the balance between tonic and phasic dopamine neuron act...

journal_title：Neuron

authors： Soden ME,Jones GL,Sanford CA,Chung AS,Güler AD,Chavkin C,Luján R,Zweifel LS

更新日期：2013-11-20 00:00:00

abstract：:Identifying the spatial organization of tissues at cellular resolution from single-cell gene expression profiles is essential to understanding biological systems. Using an in situ 3D multiplexed imaging method, seqFISH, we identify unique transcriptional states by quantifying and clustering up to 249 genes in 16,958 c...

journal_title：Neuron

authors： Shah S,Lubeck E,Zhou W,Cai L

更新日期：2016-10-19 00:00:00

abstract：:Outer hair cells (OHCs) provide amplification in the mammalian cochlea using somatic force generation underpinned by voltage-dependent conformational changes of the motor protein prestin. However, prestin must be gated by changes in membrane potential on a cycle-by-cycle basis and the periodic component of the recepto...

journal_title：Neuron

authors： Johnson SL,Beurg M,Marcotti W,Fettiplace R

更新日期：2011-06-23 00:00:00

abstract：:Recent neurophysiological studies reveal that neurons in certain brain structures carry specific signals about past and future rewards. Dopamine neurons display a short-latency, phasic reward signal indicating the difference between actual and predicted rewards. The signal is useful for enhancing neuronal processing a...

journal_title：Neuron

authors： Schultz W

更新日期：2002-10-10 00:00:00

abstract：:In addition to the classical, center/surround receptive field of neurons in the lateral geniculate nucleus (LGN), there is an extraclassical, nonlinear surround that can strongly suppress LGN responses. This form of suppression likely plays an important role in adjusting the gain of LGN responses to visual stimuli. We...

journal_title：Neuron

authors： Alitto HJ,Usrey WM

更新日期：2008-01-10 00:00:00

abstract：:In uncertain environments, decision-makers must balance two goals: they must "exploit" rewarding options but also "explore" in order to discover rewarding alternatives. Exploring and exploiting necessarily change how the brain responds to identical stimuli, but little is known about how these states, and transitions b...

journal_title：Neuron

authors： Ebitz RB,Albarran E,Moore T

更新日期：2018-01-17 00:00:00

abstract：:Biochemical studies suggest that syntaxin 1A participates in multiple protein-protein interactions in the synaptic terminal, but the in vivo significance of these interactions is poorly understood. We used a targeted mutagenesis approach to eliminate specific syntaxin binding interactions and demonstrate that Drosophi...

journal_title：Neuron

authors： Wu MN,Fergestad T,Lloyd TE,He Y,Broadie K,Bellen HJ

更新日期：1999-07-01 00:00:00

abstract：:During development, retinal ganglion cell (RGC) axons either cross or avoid the midline at the optic chiasm. In Drosophila, the Slit protein regulates midline axon crossing through repulsion. To determine the role of Slit proteins in RGC axon guidance, we disrupted Slit1 and Slit2, two of three known mouse Slit genes....

journal_title：Neuron

authors： Plump AS,Erskine L,Sabatier C,Brose K,Epstein CJ,Goodman CS,Mason CA,Tessier-Lavigne M

更新日期：2002-01-17 00:00:00

abstract：:The parietal lobes of nonhuman primates have been well characterized by single neuron recordings, yet clear partitioning of the human parietal lobes has not been clearly demonstrated. An elegant new fMRI study by Simon and colleagues (this issue of Neuron) suggests that parietal cortex does indeed contain dissociable ...

journal_title：Neuron

authors： Culham J

更新日期：2002-01-31 00:00:00

abstract：:Argiotoxin, a component of the spider venom from Argiope lobata, blocks AMPA receptor channels expressed in homomeric and heteromeric configuration in Xenopus oocytes. Argiotoxin acts as an open channel blocker in a voltage-dependent manner and discriminates between the functionally diverse AMPA receptors. Importantly...

journal_title：Neuron

authors： Herlitze S,Raditsch M,Ruppersberg JP,Jahn W,Monyer H,Schoepfer R,Witzemann V

更新日期：1993-06-01 00:00:00

abstract：:GABARAP recognizes and binds the gamma2 subunit of the GABA(A) receptor, interacts with microtubules and the N-ethyl maleimide sensitive factor, and is proposed to function in GABA(A) receptor trafficking and postsynaptic localization. We have determined the crystal structure of human GABARAP at 1.6 A resolution. The ...

journal_title：Neuron

authors： Coyle JE,Qamar S,Rajashankar KR,Nikolov DB

更新日期：2002-01-03 00:00:00

abstract：:The ability of vertebrates to detect and avoid damaging extremes of temperature depends on activation of ion channels belonging to the thermo-TRP family. Injury or inflammation causes the release of inflammatory mediators which lower the threshold for detection of painful levels of heat, a process known as heat hypera...

journal_title：Neuron

authors： Zhang X,Li L,McNaughton PA

更新日期：2008-08-14 00:00:00

abstract：:Brandon et al. (2014) show that the formation of place cell representations in new environments is preserved under septal inactivation, and is thus likely independent of the hippocampal theta rhythm and, by implication, the firing of entorhinal grid cells and the process of path integration. ...

journal_title：Neuron

authors： Hayman R,Burgess N

更新日期：2014-05-21 00:00:00

abstract：:Astrocytes are complex bushy cells that serve important functions through close contacts between their processes and synapses. However, the spatial interactions and dynamics of astrocyte processes relative to synapses have proven problematic to study in adult living brain tissue. Here, we report a genetically targeted...

journal_title：Neuron

authors： Octeau JC,Chai H,Jiang R,Bonanno SL,Martin KC,Khakh BS

更新日期：2018-04-04 00:00:00

abstract：:Classic studies of spatial attention assumed that its neural and behavioral effects were continuous over time. Recent behavioral studies have instead revealed that spatial attention leads to alternating periods of heightened or diminished perceptual sensitivity. Yet, the neural basis of these rhythmic fluctuations has...

journal_title：Neuron

authors： Fiebelkorn IC,Pinsk MA,Kastner S

更新日期：2018-08-22 00:00:00

abstract：:The combination of patch-clamp and molecular biology techniques has made it possible to characterize the pharmacological and biophysical properties of ion channels in single neurons and to screen for expression of specific mRNAs in the same cell. Following whole-cell recording, the cytoplasm of the cell is harvested, ...

journal_title：Neuron

authors： Sucher NJ,Deitcher DL

更新日期：1995-06-01 00:00:00

abstract：:The adipocyte-derived hormone leptin decreases body weight in part by activating the sympathetic nervous system, resulting in increased thermogenesis and energy expenditure. We investigated hypothalamic pathways underlying leptin's effects on stimulating the sympathetic nervous system. We found that leptin activates n...

journal_title：Neuron

authors： Elias CF,Lee C,Kelly J,Aschkenasi C,Ahima RS,Couceyro PR,Kuhar MJ,Saper CB,Elmquist JK

更新日期：1998-12-01 00:00:00

abstract：:Spine Ca(2+) is critical for the induction of synaptic plasticity, but the factors that control Ca(2+) handling in dendritic spines under physiological conditions are largely unknown. We studied [Ca(2+)] signaling in dendritic spines of CA1 pyramidal neurons and find that spines are specialized structures with low end...

journal_title：Neuron

authors： Sabatini BL,Oertner TG,Svoboda K

更新日期：2002-01-31 00:00:00

abstract：:Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We characterize AD stage-associated molecular networks by profiling 14,513 proteins and 34,173 phosphosites in the human brain with mass spectrometry, highlighting 173 protein changes in 17 pathways. The altered proteins are validated in two ...

journal_title：Neuron

authors： Bai B,Wang X,Li Y,Chen PC,Yu K,Dey KK,Yarbro JM,Han X,Lutz BM,Rao S,Jiao Y,Sifford JM,Han J,Wang M,Tan H,Shaw TI,Cho JH,Zhou S,Wang H,Niu M,Mancieri A,Messler KA,Sun X,Wu Z,Pagala V,High AA,Bi W,Zhan

更新日期：2020-03-18 00:00:00

abstract：:RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of...

journal_title：Neuron

authors： Nussbacher JK,Tabet R,Yeo GW,Lagier-Tourenne C

更新日期：2019-04-17 00:00:00

abstract：:Evolutionary conservation of members of the NGF family in vertebrates was studied by DNA sequence analysis of PCR fragments for NGF, BDNF, and NT-3 from human, rat, chicken, viper, Xenopus, salmon, and ray. The results showed that the three factors are highly conserved from fishes to mammals. Phylogenetic trees reflec...

journal_title：Neuron

authors： Hallböök F,Ibáñez CF,Persson H

更新日期：1991-05-01 00:00:00

abstract：:The formation, function, and plasticity of synapses require dynamic changes in synaptic receptor composition. Here, we identify the sorting receptor SorCS1 as a key regulator of synaptic receptor trafficking. Four independent proteomic analyses identify the synaptic adhesion molecule neurexin and the AMPA glutamate re...

journal_title：Neuron

authors： Savas JN,Ribeiro LF,Wierda KD,Wright R,DeNardo-Wilke LA,Rice HC,Chamma I,Wang YZ,Zemla R,Lavallée-Adam M,Vennekens KM,O'Sullivan ML,Antonios JK,Hall EA,Thoumine O,Attie AD,Yates JR 3rd,Ghosh A,de Wit J

更新日期：2015-08-19 00:00:00

abstract：:The mechanism coupling exocytosis and endocytosis remains to be elucidated at central synapses. Here, we show that the mechanism linking these two processes is dependent on microdomain-[Ca2+](i) similar to that which triggers exocytosis, as well as the exocytotic protein synaptobrevin/VAMP. Furthermore, block of endoc...

journal_title：Neuron

authors： Hosoi N,Holt M,Sakaba T

更新日期：2009-07-30 00:00:00

abstract：:Neural circuits consist of highly precise connections among specific types of neurons that serve a common functional goal. How neurons distinguish among different synaptic targets to form functionally precise circuits remains largely unknown. Here, we show that during development, the adhesion molecule cadherin-6 (Cdh...

journal_title：Neuron

authors： Osterhout JA,Josten N,Yamada J,Pan F,Wu SW,Nguyen PL,Panagiotakos G,Inoue YU,Egusa SF,Volgyi B,Inoue T,Bloomfield SA,Barres BA,Berson DM,Feldheim DA,Huberman AD

更新日期：2011-08-25 00:00:00

abstract：:Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter mi...

journal_title：Neuron

authors： Renthal W,Kumar A,Xiao G,Wilkinson M,Covington HE 3rd,Maze I,Sikder D,Robison AJ,LaPlant Q,Dietz DM,Russo SJ,Vialou V,Chakravarty S,Kodadek TJ,Stack A,Kabbaj M,Nestler EJ

更新日期：2009-05-14 00:00:00