Abstract:
:We have cloned the rat gene encoding peripherin, a neuronal-specific intermediate filament protein that is NGF-regulated. Determination of the complete sequence, including 821 nucleotides of the 5'-flanking region, allows us to make conclusions about the evolutionary origin of the peripherin gene, its homology with other intermediate filament proteins, and possible mechanisms of regulation of peripherin expression in neurons. The positions of the eight peripherin gene introns correspond to the intron patterns of desmin, vimentin, and GFAP, with one example of intron sliding. Together with protein sequence homologies, this conclusively demonstrates that peripherin is a type III intermediate filament protein. The peripherin promoter contains sequences homologous to regions of other NGF-regulated promoters, which may function in peripherin induction by NGF.
journal_name
Neuronjournal_title
Neuronauthors
Thompson MA,Ziff EBdoi
10.1016/0896-6273(89)90228-6subject
Has Abstractpub_date
1989-01-01 00:00:00pages
1043-53issue
1eissn
0896-6273issn
1097-4199pii
0896-6273(89)90228-6journal_volume
2pub_type
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