Targeting Homer1a for Rapid Antidepressant Effects.

abstract：:The structural basis for the synthesis of specific proteins within distinct intraneuronal compartments is unknown. We studied the distribution of poly(A) mRNA within cultured cerebrocortical neurons using high resolution in situ hybridization to identify cytoskeletal components that may anchor mRNA. After 1 day in cul...

journal_title：Neuron

authors： Bassell GJ,Singer RH,Kosik KS

更新日期：1994-03-01 00:00:00

abstract：:Effective mental functioning requires that cognition be protected from emotional conflict due to interference by task-irrelevant emotionally salient stimuli. The neural mechanisms by which the brain detects and resolves emotional conflict are still largely unknown, however. Drawing on the classic Stroop conflict task,...

journal_title：Neuron

authors： Etkin A,Egner T,Peraza DM,Kandel ER,Hirsch J

更新日期：2006-09-21 00:00:00

abstract：:Neural representations of head direction (HD) have been discovered in many species. Theoretical work has proposed that the dynamics associated with these representations are generated, maintained, and updated by recurrent network structures called ring attractors. We evaluated this theorized structure-function relatio...

journal_title：Neuron

authors： Turner-Evans DB,Jensen KT,Ali S,Paterson T,Sheridan A,Ray RP,Wolff T,Lauritzen JS,Rubin GM,Bock DD,Jayaraman V

更新日期：2020-10-14 00:00:00

abstract：:At the optic chiasm, axons from either eye meet and decide whether to cross contralaterally or turn back ipsilaterally. Here, the guidance ligand Slit and its receptor Robo control not whether axons cross (as in other midline decisions), but where the chiasm forms. Whether axons cross is instead controlled by the tran...

journal_title：Neuron

authors： Rasband K,Hardy M,Chien CB

更新日期：2003-09-11 00:00:00

abstract：:Reversible silencing of neuronal activity is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal excitation, for which the majority of studies have used a limited number of optogenetic and chemogenetic tools, the number of genetically...

journal_title：Neuron

authors： Wiegert JS,Mahn M,Prigge M,Printz Y,Yizhar O

更新日期：2017-08-02 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder with no known cure. The etiology of PD is likely due, in part, to combinations of genetic susceptibilities and environmental factors. In rare familial cases, PD is due to genetic mutations. A number of new genetic and toxin models of PD and advances in ol...

journal_title：Neuron

authors： Dawson T,Mandir A,Lee M

更新日期：2002-07-18 00:00:00

abstract：:For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems. ...

journal_title：Neuron

authors： McAllister AK,van de Water J

更新日期：2009-10-15 00:00:00

abstract：:The development and homeostasis of neurons relies heavily on the selective targeting of vesicles into axon and dendrites. Microtubule-based motor proteins play an important role in polarized transport; however, the sorting mechanism to exclude dendritic cargo from the axon is unclear. We show that the dynein regulator...

journal_title：Neuron

authors： Kuijpers M,van de Willige D,Freal A,Chazeau A,Franker MA,Hofenk J,Rodrigues RJ,Kapitein LC,Akhmanova A,Jaarsma D,Hoogenraad CC

更新日期：2016-02-03 00:00:00

abstract：:An autosomal recessive juvenile-onset form of Parkinson's disease (AR-JP) is caused by loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase. Three recent reports demonstrate that parkin can protect neurons from diverse cellular insults, including alpha-synuclein toxicity, proteasomal...

journal_title：Neuron

authors： Feany MB,Pallanck LJ

更新日期：2003-04-10 00:00:00

abstract：:Following alpha-latrotoxin application to cerebellar slices, bursts of miniature IPSCs (mIPSCs) were observed in interneurons of the molecular layer. Within bursts, mIPSCs had homogeneous amplitudes with a narrow Gaussian distribution. Analysis of successive event amplitudes revealed an interaction between consecutive...

journal_title：Neuron

authors： Auger C,Marty A

更新日期：1997-07-01 00:00:00

abstract：:Brief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and climbing fiber EPSCs for tens of seconds. This depolarization-induced suppression of excitation (DSE) is accompanied by altered paired-pulse plasticity, suggesting a presynaptic locus. Fluorometric imaging revealed that postsynap...

journal_title：Neuron

authors： Kreitzer AC,Regehr WG

更新日期：2001-03-01 00:00:00

abstract：:TRPA1 is a promising target for the development of novel treatments for chronic pain. In this issue of Neuron, Liu et al. (2021) report a novel non-covalent TRPA1-biased agonist, GNE551, revealing a unique binding pocket by cryo-EM and activation properties that pave a path toward new avenues in the treatment of chron...

journal_title：Neuron

authors： Fine M,Li X

更新日期：2021-01-20 00:00:00

abstract：:Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits. ...

journal_title：Neuron

authors： Udeochu J,Sayed FA,Gan L

更新日期：2018-03-07 00:00:00

abstract：:Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I...

journal_title：Neuron

authors： Feldman DE

更新日期：2000-07-01 00:00:00

abstract：:Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB(1) receptors and protecting against excitotoxicity. Such excitotoxic brain lesions initially result in primary destruction of brain parenchyma, which attracts macrophages and microglia. These inflammatory cells ...

journal_title：Neuron

authors： Eljaschewitsch E,Witting A,Mawrin C,Lee T,Schmidt PM,Wolf S,Hoertnagl H,Raine CS,Schneider-Stock R,Nitsch R,Ullrich O

更新日期：2006-01-05 00:00:00

abstract：:Several aspects of perception, particularly those pertaining to vision, are closely linked to the occipital alpha (alpha) rhythm. However, how the alpha rhythm relates to the activity of neurons that convey primary visual information is unknown. Here we show that in behaving cats, thalamocortical neurons in the latera...

journal_title：Neuron

authors： Lorincz ML,Kékesi KA,Juhász G,Crunelli V,Hughes SW

更新日期：2009-09-10 00:00:00

abstract：:We generated transgenic mice that specifically express foreign genes in myelinating Schwann cells. A 1.1 kb segment of 5' flanking sequence from the rat P0 gene was used to drive expression of the genes encoding human growth hormone (hGH) and bacterial diphtheria toxin A chain (DT-A). The P0-hGH mice expressed hGH in ...

journal_title：Neuron

authors： Messing A,Behringer RR,Hammang JP,Palmiter RD,Brinster RL,Lemke G

更新日期：1992-03-01 00:00:00

abstract：:Synaptic vesicles are tethered to the active zone where they are docked/primed so that they can fuse rapidly upon Ca(2+) influx. To directly study these steps at a CNS presynaptic terminal, we used total internal reflection fluorescence (TIRF) microscopy at the live isolated calyx of Held terminal and measured the mov...

journal_title：Neuron

authors： Midorikawa M,Sakaba T

更新日期：2015-11-04 00:00:00

abstract：:Learning can be characterized as the extraction of reliable predictions about stimulus occurrences from past experience. In two experiments, we investigated the interval of temporal integration of previous learning trials in different brain regions using implicit and explicit Pavlovian fear conditioning with a dynamic...

journal_title：Neuron

authors： Gläscher J,Büchel C

更新日期：2005-07-21 00:00:00

abstract：:Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...

journal_title：Neuron

authors： Divakaruni SS,Van Dyke AM,Chandra R,LeGates TA,Contreras M,Dharmasri PA,Higgs HN,Lobo MK,Thompson SM,Blanpied TA

更新日期：2018-11-21 00:00:00

abstract：:Existing models of Huntington's disease posit that deficits in BDNF delivery to the striatum contribute to atrophy and motor impairment. In this issue of Neuron, Plotkin et al. (2014) show that BDNF delivery is normal but downstream signaling via TrkB and p75 is impaired, leading to corticostriatal synaptic dysfunctio...

journal_title：Neuron

authors： Parsons MP,Raymond LA

更新日期：2014-07-02 00:00:00

abstract：:Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presy...

journal_title：Neuron

authors： Varoqueaux F,Aramuni G,Rawson RL,Mohrmann R,Missler M,Gottmann K,Zhang W,Südhof TC,Brose N

更新日期：2006-09-21 00:00:00

abstract：:Neuronal cell migration in the developing neocortex relies on the Reelin signaling cascade to establish the characteristic "inside out" lamination pattern. In this issue of Neuron, Rakic and colleagues report that Notch signaling, long known to regulate neural stem cells, also plays a critical role in mediating the ef...

journal_title：Neuron

authors： Gaiano N

更新日期：2008-10-23 00:00:00

abstract：:Studies of the innervation of limb muscles by spinal motor neurons have helped to define mechanisms by which axons establish trajectories to their targets. Related motor axons select dorsal or ventral pathways at the base of the limb, raising the question of how these alternate trajectories are specified. EphA signali...

journal_title：Neuron

authors： Luria V,Krawchuk D,Jessell TM,Laufer E,Kania A

更新日期：2008-12-26 00:00:00

abstract：:Motion detection is a fundamental neural computation performed by many sensory systems. In the fly, local motion computation is thought to occur within the first two layers of the visual system, the lamina and medulla. We constructed specific genetic driver lines for each of the 12 neuron classes in the lamina. We the...

journal_title：Neuron

authors： Tuthill JC,Nern A,Holtz SL,Rubin GM,Reiser MB

更新日期：2013-07-10 00:00:00

abstract：:Despite the fact that strong trial-to-trial correlated variability in responses has been reported in many cortical areas, recent evidence suggests that neuronal correlations are much lower than previously thought. Here, we used multicontact laminar probes to revisit the issue of correlated variability in primary visua...

journal_title：Neuron

authors： Hansen BJ,Chelaru MI,Dragoi V

更新日期：2012-11-08 00:00:00

abstract：:We present evidence that synapse retraction occurs during normal synaptic growth at the Drosophila neuromuscular junction (NMJ). An RNAi-based screen to identify the molecular mechanisms that regulate synapse retraction identified Arp-1/centractin, a subunit of the dynactin complex. Arp-1 dsRNA enhances synapse retrac...

journal_title：Neuron

authors： Eaton BA,Fetter RD,Davis GW

更新日期：2002-05-30 00:00:00

abstract：:The auditory cortex encodes information about sounds through the combined activity of large numbers of neurons, but the way this population activity is organized has not been clear. In this issue of Neuron, Bathellier et al. (2012) show that firing in the superficial layers of auditory cortex is organized into a small...

journal_title：Neuron

authors： Harris KD

更新日期：2012-10-18 00:00:00

abstract：:Respiration is a rhythmic activity as well as one that requires responsiveness to internal and external circumstances; both the rhythm and neuromodulatory responses of breathing are controlled by brainstem neurons in the preBötzinger complex (preBötC) and the retrotrapezoid nucleus (RTN), but the specific ion channels...

journal_title：Neuron

authors： Yeh SY,Huang WH,Wang W,Ward CS,Chao ES,Wu Z,Tang B,Tang J,Sun JJ,Esther van der Heijden M,Gray PA,Xue M,Ray RS,Ren D,Zoghbi HY

更新日期：2017-04-19 00:00:00

abstract：:Inhibitory neurons, which play a critical role in decision-making models, are often simplified as a single pool of non-selective neurons lacking connection specificity. This assumption is supported by observations in the primary visual cortex: inhibitory neurons are broadly tuned in vivo and show non-specific connecti...

journal_title：Neuron

authors： Najafi F,Elsayed GF,Cao R,Pnevmatikakis E,Latham PE,Cunningham JP,Churchland AK

更新日期：2020-01-08 00:00:00