A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals.

abstract：:M-current is widespread in the nervous system. It stabilizes cell excitability, and its suppression by muscarinic receptor activation underlies slow synaptic transmission in sympathetic neurons. Suppression of M-current was one of the first examples of neuromodulation of a potassium current, but the mechanism is not u...

journal_title：Neuron

authors： Marrion NV

更新日期：1993-07-01 00:00:00

abstract：:Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFR alpha), suggesting that PDGF mediates a paracrine interaction between these cells. T...

journal_title：Neuron

authors： Fruttiger M,Calver AR,Krüger WH,Mudhar HS,Michalovich D,Takakura N,Nishikawa S,Richardson WD

更新日期：1996-12-01 00:00:00

abstract：:Recent studies have shown that hippocampal "time cells" code for sequential moments in temporally organized experiences. However, it is currently unknown whether these temporal firing patterns critically rely on upstream cortical input. Here we employ an optogenetic approach to explore the effect of large-scale inacti...

journal_title：Neuron

authors： Robinson NTM,Priestley JB,Rueckemann JW,Garcia AD,Smeglin VA,Marino FA,Eichenbaum H

更新日期：2017-05-03 00:00:00

abstract：:The regulation of quantal size through pre- rather than postsynaptic mechanisms has recently received considerable attention as a potential mechanism for plasticity. Vesicular transporters catalyze the filling of synaptic vesicles with transmitter and are thus potential substrates for such presynaptic regulation. In t...

journal_title：Neuron

authors： Hnasko TS,Edwards RH

更新日期：2006-09-07 00:00:00

abstract：:Spine Ca(2+) is critical for the induction of synaptic plasticity, but the factors that control Ca(2+) handling in dendritic spines under physiological conditions are largely unknown. We studied [Ca(2+)] signaling in dendritic spines of CA1 pyramidal neurons and find that spines are specialized structures with low end...

journal_title：Neuron

authors： Sabatini BL,Oertner TG,Svoboda K

更新日期：2002-01-31 00:00:00

abstract：:The dopaminergic D3 receptor (D3R) is emerging as an antagonist of sensitized behavior induced by addictive drugs such as cocaine. New work by Wang and coworkers in this issue of Neuron now identifies CaMKII as an important negative regulator of the D3R. CaMKII relieves the D3R-mediated inhibition on sensitized behavi...

journal_title：Neuron

authors： Hell JW

更新日期：2009-02-12 00:00:00

abstract：:Although numerous theoretical models implicate the prefrontal cortex (PFC) as a source of top-down control signals, empirical support is limited. In this review, we highlight direct evidence for this view of PFC function and discuss several lines of other supportive findings. Most evidence to-date is only suggestive d...

journal_title：Neuron

authors： Miller BT,D'Esposito M

更新日期：2005-11-23 00:00:00

abstract：:The processing of sensory information varies widely across behavioral states. However, little is known about how behavioral states modulate the intracellular activity of cortical neurons to effect changes in sensory responses. Here, we performed whole-cell recordings from neurons in upper-layer primary visual cortex o...

journal_title：Neuron

authors： Bennett C,Arroyo S,Hestrin S

更新日期：2013-10-16 00:00:00

abstract：:In this issue of Neuron, Stepanyants et al. embark on quantitative analyses of the axonal and dendritic arbors of cortical neurons. They test whether the paths taken by axons actually bring them closer to their true synaptic partners than they would have gotten by chance encounters based on the same axon trajectories....

journal_title：Neuron

authors： Callaway EM

更新日期：2004-07-22 00:00:00

abstract：:In this issue of Neuron, Tufail et al. present an underlying mechanism for microglia-mediated elimination of virally transduced cells in the central nervous system. These findings could contribute to the development of improved gene therapies for various neurological disorders by exploring why microglia destroy viable...

journal_title：Neuron

authors： Pluvinage JV,Wyss-Coray T

更新日期：2017-02-08 00:00:00

abstract：:Charybdotoxin (CTX) blocks high conductance Ca(2+)-activated K+ channels by binding to a receptor site in the externally facing "mouth." Toxin bound to the channel can be destabilized from its site by K+ entering the channel from the opposite, internal, solution. By analyzing point mutants of CTX expressed in E. coli,...

journal_title：Neuron

authors： Park CS,Miller C

更新日期：1992-08-01 00:00:00

abstract：:A meta-analysis of non-human primates performing three different tasks (Object-Match, Category-Match, and Category-Saccade associations) revealed signatures of explicit and implicit learning. Performance improved equally following correct and error trials in the Match (explicit) tasks, but it improved more after corre...

journal_title：Neuron

authors： Loonis RF,Brincat SL,Antzoulatos EG,Miller EK

更新日期：2017-10-11 00:00:00

abstract：:EPAC proteins are the guanine nucleotide exchange factors that act as the intracellular receptors for cyclic AMP. Two variants of EPAC genes including EPAC1 and EPAC2 are cloned and are widely expressed throughout the brain. But, their functions in the brain remain unknown. Here, we genetically delete EPAC1 (EPAC1(-/-...

journal_title：Neuron

authors： Yang Y,Shu X,Liu D,Shang Y,Wu Y,Pei L,Xu X,Tian Q,Zhang J,Qian K,Wang YX,Petralia RS,Tu W,Zhu LQ,Wang JZ,Lu Y

更新日期：2012-02-23 00:00:00

abstract：:We provide physiological, pharmacological, and structural evidence that axons of hippocampal principal cells are electrically coupled, with prepotentials or spikelets forming the physiological substrate of electrical coupling as observed in cell somata. Antidromic activation of neighboring axons induced somatic spikel...

journal_title：Neuron

authors： Schmitz D,Schuchmann S,Fisahn A,Draguhn A,Buhl EH,Petrasch-Parwez E,Dermietzel R,Heinemann U,Traub RD

更新日期：2001-09-13 00:00:00

abstract：:Phorbol esters and purified protein kinase C (PKC) have been shown to down-modulate the voltage-dependent Na+ channels expressed in Xenopus oocytes injected with chick brain RNA. We used the two-electrode voltage-clamp technique to demonstrate that a Na+ channel expressed in oocytes injected with RNA coding for the al...

journal_title：Neuron

authors： Dascal N,Lotan I

更新日期：1991-01-01 00:00:00

abstract：:Striatal dopamine plays key roles in our normal and pathological goal-directed actions. To understand dopamine function, much attention has focused on how midbrain dopamine neurons modulate their firing patterns. However, we identify a presynaptic mechanism that triggers dopamine release directly, bypassing activity i...

journal_title：Neuron

authors： Threlfell S,Lalic T,Platt NJ,Jennings KA,Deisseroth K,Cragg SJ

更新日期：2012-07-12 00:00:00

abstract：:Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly from the medial geniculate nucleus and indirectly from the auditory cortex. Here we show in the cortico-amygdala pathway that learned fear occludes electricall...

journal_title：Neuron

authors： Tsvetkov E,Carlezon WA,Benes FM,Kandel ER,Bolshakov VY

更新日期：2002-04-11 00:00:00

abstract：:Cognitive deficits in fragile X syndrome (FXS) are attributed to molecular abnormalities of the brain's vast and heterogeneous synapse populations. Unfortunately, the density of synapses coupled with their molecular heterogeneity presents formidable challenges in understanding the specific contribution of synapse chan...

journal_title：Neuron

authors： Wang GX,Smith SJ,Mourrain P

更新日期：2014-12-17 00:00:00

abstract：:Telling time and anticipating when external events will happen is among the most important tasks the brain performs. Yet the neural mechanisms underlying timing remain elusive. One theory proposes that timing is a general and intrinsic computation of cortical circuits. We tested this hypothesis using electrical and op...

journal_title：Neuron

authors： Goel A,Buonomano DV

更新日期：2016-07-20 00:00:00

abstract：:Cellular Ca2+ buffers determine amplitude and diffusional spread of neuronal Ca2+ signals. Fixed Ca2+ buffers tend to retard the signal and to lower the apparent diffusion coefficient (D(app)) of Ca2+, whereas mobile buffers contribute to Ca2+ redistribution. To estimate the impact of the expression of specific Ca2+-b...

journal_title：Neuron

authors： Gabso M,Neher E,Spira ME

更新日期：1997-03-01 00:00:00

abstract：:The neural circuits governing vital behaviors, such as respiration and locomotion, are comprised of discrete neuronal populations residing within the brainstem and spinal cord. Work over the past decade has provided a fairly comprehensive understanding of the developmental pathways that determine the identity of major...

journal_title：Neuron

authors： Philippidou P,Dasen JS

更新日期：2013-10-02 00:00:00

abstract：:Gene expression may occur in unexpected ectopic sites when diverse genetic elements are juxtaposed as chimeric genes in transgenic mice. To determine the specific contribution of the promoter and reporter gene in ectopic expression, we have analyzed the expression of 14 different fusion genes in transgenic mice. Chime...

journal_title：Neuron

authors： Russo AF,Crenshaw EB 3rd,Lira SA,Simmons DM,Swanson LW,Rosenfeld MG

更新日期：1988-06-01 00:00:00

abstract：:Retinal specializations such as cone-photoreceptor opsin-expression gradients, as found in several vertebrate species, are intuitively considered detrimental to color vision. In mice, the majority of cones coexpress both "blue" and "green" opsin. The coexpression ratio changes along the dorsoventral axis, resulting in...

journal_title：Neuron

authors： Chang L,Breuninger T,Euler T

更新日期：2013-02-06 00:00:00

abstract：:The study of patients with brain lesions has made major historical contributions to cognitive neuroscience. Here I argue for an increased investment in modern lesion mapping, complementing fMRI studies and laying the conceptual and analytic foundations for future techniques that could experimentally manipulate human b...

journal_title：Neuron

authors： Adolphs R

更新日期：2016-06-15 00:00:00

abstract：:In rodents, each main olfactory bulb contains two mirror-symmetric glomerular maps, a feature not found in the initial topographic maps of other sensory systems. Targeting tracer injections to identified glomeruli revealed that isofunctional odor columns-translaminar assemblies connected to a given glomerulus-were spe...

journal_title：Neuron

authors： Lodovichi C,Belluscio L,Katz LC

更新日期：2003-04-24 00:00:00

abstract：:Cholinergic interneurons (CHIs) play a major role in motor and learning functions of the striatum. As acetylcholine does not directly evoke postsynaptic events at most striatal synapses, it remains unclear how postsynaptic cholinergic receptors encode the firing patterns of CHIs in the striatum. To examine the dynamic...

journal_title：Neuron

authors： Mamaligas AA,Ford CP

更新日期：2016-08-03 00:00:00

abstract：:GABAergic, somatostatin-containing bitufted interneurons in layer 2/3 of rat neocortex are excited via glutamatergic excitatory postsynaptic potentials (EPSPs) by pyramidal neurons located in the same cortical layer. Pair recordings showed that short bursts of backpropagating dendritic action potentials (APs) reduced ...

journal_title：Neuron

authors： Zilberter Y,Kaiser KM,Sakmann B

更新日期：1999-12-01 00:00:00

abstract：:In situ hybridization histochemistry reveals localized expression of the nicotinic acetylcholine receptor (nAChR) alpha 2 subunit mRNA restricted to the lateral spiriform nucleus (SpL) of the chick diencephalon. The alpha 2 nAChR transcripts are not detected in immature SpL neurons at 4.5-5 days of embryonic developme...

journal_title：Neuron

authors： Daubas P,Devillers-Thiéry A,Geoffroy B,Martinez S,Bessis A,Changeux JP

更新日期：1990-07-01 00:00:00

abstract：:Experimental evidence shows that the inability to attribute mental states, such as desires and beliefs, to self and others (mentalizing) explains the social and communication impairments of individuals with autism. Brain imaging studies in normal volunteers highlight a circumscribed network that is active during menta...

journal_title：Neuron

authors： Frith U

更新日期：2001-12-20 00:00:00

abstract：:Attention or variations in event processing help drive learning. Lesion studies have implicated the central nucleus of the amygdala (CeA) in this process, particularly when expected rewards are omitted. However, lesion studies cannot specify how information processing in CeA supports such learning. To address these qu...

journal_title：Neuron

authors： Calu DJ,Roesch MR,Haney RZ,Holland PC,Schoenbaum G

更新日期：2010-12-09 00:00:00