Abstract:
:Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly from the medial geniculate nucleus and indirectly from the auditory cortex. Here we show in the cortico-amygdala pathway that learned fear occludes electrically induced long-term potentiation (LTP). Quantal analysis of the expression of LTP in this pathway reveals a significant presynaptic component reflected in an increase in probability of transmitter release. Conditioned fear also is accompanied by the enhancement in transmitter release at this cortico-amygdala synapse. These results indicate that the synaptic projections from the auditory cortex to the lateral amygdala are modified during the acquisition and expression of fear to auditory stimulation, thus further strengthening the proposed link between LTP in the auditory pathways to the amygdala and learned fear.
journal_name
Neuronjournal_title
Neuronauthors
Tsvetkov E,Carlezon WA,Benes FM,Kandel ER,Bolshakov VYdoi
10.1016/s0896-6273(02)00645-1subject
Has Abstractpub_date
2002-04-11 00:00:00pages
289-300issue
2eissn
0896-6273issn
1097-4199pii
S0896627302006451journal_volume
34pub_type
杂志文章相关文献
NEURON文献大全abstract::Targeted therapy for neuropsychiatric disorders requires selective modulation of dysfunctional neuronal pathways. Receptors relevant to CNS disorders typically have associated proteins discretely expressed in specific neuronal pathways; these accessory proteins provide a new dimension for drug discovery. Recent studie...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.10.001
更新日期:2017-12-06 00:00:00
abstract::Sequential neural activity patterns are as ubiquitous as the outputs they drive, which include motor gestures and sequential cognitive processes. Neural sequences are long, compared to the activation durations of participating neurons, and sequence coding is sparse. Numerous studies demonstrate that spike-time-depende...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.02.003
更新日期:2010-02-25 00:00:00
abstract::We used fMRI to investigate how moment-to-moment neural activity contributes to success or failure on individual trials of a visual working memory (WM) task. We found that different nodes of a distributed cortical network were activated to a greater extent for correct compared to incorrect trials during stimulus encod...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00817-6
更新日期:2002-08-29 00:00:00
abstract::Hippocampal dentate granule cell abnormalities are thought to play a causative role in temporal lobe epilepsy, but their precise contribution has not been dissociated from coexisting pathological changes. In this issue of Neuron, Pun et al. (2012) show, for the first time, that inducing proexcitatory changes in a subs...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2012.09.008
更新日期:2012-09-20 00:00:00
abstract::Depending on the arousal state, neuronal networks display discrete activity patterns that profoundly affect information processing in the brain. In this issue of Neuron, Kurotani et al. report bidirectional modification of inhibition by oscillatory patterns in the neocortex; a mechanism likely to control the impact of...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2008.03.010
更新日期:2008-03-27 00:00:00
abstract::Long-term memory and synaptic plasticity are thought to require the synthesis of new proteins at activated synapses. The CPEB family of RNA binding proteins, including Drosophila Orb2, has been implicated in this process. The precise mechanism by which these molecules regulate memory formation is however poorly unders...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.08.028
更新日期:2012-10-18 00:00:00
abstract::The signaling mechanisms that control the survival of CNS neurons are poorly understood. Here we show that, in contrast to PNS neurons, the survival of purified postnatal rat retinal ganglion cells (RGCs) in vitro is not promoted by peptide trophic factors unless their intracellular cAMP is increased pharmacologically...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90172-8
更新日期:1995-10-01 00:00:00
abstract::Glutamate receptors mediate the majority of rapid excitatory synaptic transmission in the central nervous system (CNS) and play important roles in synaptic plasticity and neuronal development. Recently, protein-protein interactions with the C-terminal domain of glutamate receptor subunits have been shown to be involve...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80548-6
更新日期:1998-08-01 00:00:00
abstract::Although nitric oxide (NO) is produced by discrete groups of neurons in the brain, participation of NO in premotor structures directly involved in reflexively evoked, sensory-motor functions has not been demonstrated so far. We now show that NO is a physiological mediator in the generation of a specific motor response...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80205-6
更新日期:1996-10-01 00:00:00
abstract::Tau is abundant in the axon, whereas MAP2 is found in the cell body and dendrites. To understand their differential localization, we performed transfection studies on primary cultured neurons using tagged tau, MAP2, MAP2C, and their chimeric/deletion mutants. We found that MAP2 was prevented from entering the axon by ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90298-8
更新日期:1995-02-01 00:00:00
abstract::Effective mental functioning requires that cognition be protected from emotional conflict due to interference by task-irrelevant emotionally salient stimuli. The neural mechanisms by which the brain detects and resolves emotional conflict are still largely unknown, however. Drawing on the classic Stroop conflict task,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.07.029
更新日期:2006-09-21 00:00:00
abstract::Myelinated fibers are organized into distinct domains that are necessary for saltatory conduction. These domains include the nodes of Ranvier and the flanking paranodal regions where glial cells closely appose and form specialized septate-like junctions with axons. These junctions contain a Drosophila Neurexin IV-rela...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00294-x
更新日期:2001-05-01 00:00:00
abstract::Our tactile perception of external objects depends on skin-object interactions. The mechanics of contact dictates the existence of fundamental spatiotemporal input features-contact initiation and cessation, slip, and rolling contact-that originate from the fact that solid objects do not interpenetrate. However, it is ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.07.038
更新日期:2014-09-17 00:00:00
abstract::Recent neurophysiological studies reveal that neurons in certain brain structures carry specific signals about past and future rewards. Dopamine neurons display a short-latency, phasic reward signal indicating the difference between actual and predicted rewards. The signal is useful for enhancing neuronal processing a...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(02)00967-4
更新日期:2002-10-10 00:00:00
abstract::Dscam1 potentially encodes 19,008 ectodomains of a cell recognition molecule of the immunoglobulin (Ig) superfamily through alternative splicing. Each ectodomain, comprising a unique combination of three variable (Ig) domains, exhibits isoform-specific homophilic binding in vitro. Although we have proposed that the ab...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.02.029
更新日期:2012-04-26 00:00:00
abstract::Interaction with the multi-PDZ protein GRIP is required for the synaptic targeting of AMPA receptors, but the underlying mechanism is unknown. We show that GRIP binds to the liprin-alpha/SYD2 family of proteins that interact with LAR receptor protein tyrosine phosphatases (LAR-RPTPs) and that are implicated in presyna...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00640-2
更新日期:2002-03-28 00:00:00
abstract::Studies of the innervation of limb muscles by spinal motor neurons have helped to define mechanisms by which axons establish trajectories to their targets. Related motor axons select dorsal or ventral pathways at the base of the limb, raising the question of how these alternate trajectories are specified. EphA signali...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.11.011
更新日期:2008-12-26 00:00:00
abstract::The alpha subunit of a voltage-sensitive sodium channel characteristic of denervated rat skeletal muscle was cloned and characterized. The cDNA encodes a 2018 amino acid protein (SkM2) that is homologous to other recently cloned sodium channels, including a tetrodotoxin (TTX)-sensitive sodium channel from rat skeletal...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90098-z
更新日期:1990-02-01 00:00:00
abstract::A new fluorescence method using the dye FM1-43 was used to examine exocytotic release from hippocampal synaptosomes. Nitric oxide caused a marked transient stimulation of vesicle release. Several structurally unrelated nitric oxide donors, sodium nitroprusside, S-nitroso-N-acetylpenicillamine, 3-morpholino-sydnonimine...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90440-5
更新日期:1994-06-01 00:00:00
abstract::Local neuronal networks that are responsible for walking are poorly characterized in mammals. Using an innovative approach to identify interneuron inputs onto motorneuron populations in a neonatal rodent spinal cord preparation, we have investigated the network responsible for left-right coordination of the hindlimbs....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00353-2
更新日期:2003-06-19 00:00:00
abstract::M-current is widespread in the nervous system. It stabilizes cell excitability, and its suppression by muscarinic receptor activation underlies slow synaptic transmission in sympathetic neurons. Suppression of M-current was one of the first examples of neuromodulation of a potassium current, but the mechanism is not u...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90272-s
更新日期:1993-07-01 00:00:00
abstract::Zika virus (ZIVK) represents a new threat to global health, with particular relevance to neuroscientists, due to associated newborn and adult neurological disease. Consequences of vertical infection include microcephaly with brain and eye anomalies, and consequences of adult infection include Guillain-Barré syndrome (...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2016.11.031
更新日期:2016-12-07 00:00:00
abstract::During normal vision, the focus of gaze continually jumps from one important image feature to the next. In this issue of Neuron, Mazer and Gallant analyze neural activity in higher-level visual cortex during this kind of active visual exploration, and they demonstrate a localized enhancement of visual responses that p...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00805-5
更新日期:2003-12-18 00:00:00
abstract::In this issue of Neuron, Gantz and Bean (2017) show that the endocannabinoid 2-arachidonoyl glycerol (2-AG) can directly alter the properties of native ion-channel Kv4.3 and accelerate the pacemaker activity of rodent dopamine neurons. These findings are one of the first demonstrations of postsynaptic, cell-autonomous...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.03.014
更新日期:2017-03-22 00:00:00
abstract::Retinal specializations such as cone-photoreceptor opsin-expression gradients, as found in several vertebrate species, are intuitively considered detrimental to color vision. In mice, the majority of cones coexpress both "blue" and "green" opsin. The coexpression ratio changes along the dorsoventral axis, resulting in...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.12.012
更新日期:2013-02-06 00:00:00
abstract::Two studies in this issue of Neuron challenge widely held assumptions about the role of positive feedback in recurrent neuronal networks. Goldman shows that such feedback is not necessary for memory maintenance in a neural integrator, and Murphy and Miller show that it is not necessary for amplification of orientation...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.02.006
更新日期:2009-02-26 00:00:00
abstract::Recent advances in connectomics have led to a synthesis of perspectives regarding the brain's functional organization that reconciles classical concepts of localized specialization with an appreciation for properties that emerge from interactions across distributed functional networks. This provides a more comprehensi...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2016.07.031
更新日期:2016-08-03 00:00:00
abstract::Which neurons in the brain "decide" to initiate particular behaviors in response to sensory information? In this issue of Neuron, two papers (Kohatsu et al. and von Philipsborn et al.) identify candidates in the courtship circuitry of Drosophila. The activity of these neurons is both regulated by sex pheromones and ne...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2011.01.021
更新日期:2011-02-10 00:00:00
abstract::The formation of topographic neural maps relies on the coordinate assignment of neuronal cell body position and axonal trajectory. The projection of motor neurons of the lateral motor column (LMC) along the dorsoventral axis of the limb mesenchyme constitutes a simple topographic map that is organized in a binary mann...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00292-7
更新日期:2003-05-22 00:00:00
abstract::The establishment of axon-dendrite polarity is fundamental for radial migration of neurons during cortex development of mammals. We demonstrate that the E3 ubiquitin ligases WW-Containing Proteins 1 and 2 (Wwp1 and Wwp2) are indispensable for proper polarization of developing neurons. We show that knockout of Wwp1 and...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.10.008
更新日期:2018-12-05 00:00:00