Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex.

abstract：:Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presy...

journal_title：Neuron

authors： Varoqueaux F,Aramuni G,Rawson RL,Mohrmann R,Missler M,Gottmann K,Zhang W,Südhof TC,Brose N

更新日期：2006-09-21 00:00:00

abstract：:The alpha subunit of a voltage-sensitive sodium channel characteristic of denervated rat skeletal muscle was cloned and characterized. The cDNA encodes a 2018 amino acid protein (SkM2) that is homologous to other recently cloned sodium channels, including a tetrodotoxin (TTX)-sensitive sodium channel from rat skeletal...

journal_title：Neuron

authors： Kallen RG,Sheng ZH,Yang J,Chen LQ,Rogart RB,Barchi RL

更新日期：1990-02-01 00:00:00

abstract：:The performance of a task is often assumed to be a prerequisite for the learning of many tasks, including the associative conditioning of courtship in the fruit fly, Drosophila melanogaster. Transgenic flies specifically inhibited for the enzyme protein kinase C dissociate the acquisition of learning and memory from p...

journal_title：Neuron

authors： Kane NS,Robichon A,Dickinson JA,Greenspan RJ

更新日期：1997-02-01 00:00:00

abstract：:Myelin ensheathes axons to allow rapid propagation of action potentials and proper nervous system function. In the peripheral nervous system, Schwann cells (SCs) radially sort axons into a 1:1 relationship before wrapping an axonal segment to form myelin. SC myelination requires the adhesion G protein-coupled receptor...

journal_title：Neuron

authors： Petersen SC,Luo R,Liebscher I,Giera S,Jeong SJ,Mogha A,Ghidinelli M,Feltri ML,Schöneberg T,Piao X,Monk KR

更新日期：2015-02-18 00:00:00

abstract：:We have identified the species of K+ channel that underlies the neuronal M-current in rat sympathetic ganglion cells. The channels were kinetically and pharmacologically defined using outside-out and cell-attached patches. They exhibited multiple conductance levels, predominantly 3-9 pS. Their slow gating in response ...

journal_title：Neuron

authors： Stansfeld CE,Marsh SJ,Gibb AJ,Brown DA

更新日期：1993-04-01 00:00:00

abstract：:In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom ...

journal_title：Neuron

authors： Perisse E,Owald D,Barnstedt O,Talbot CB,Huetteroth W,Waddell S

更新日期：2016-06-01 00:00:00

abstract：:We present evidence that synapse retraction occurs during normal synaptic growth at the Drosophila neuromuscular junction (NMJ). An RNAi-based screen to identify the molecular mechanisms that regulate synapse retraction identified Arp-1/centractin, a subunit of the dynactin complex. Arp-1 dsRNA enhances synapse retrac...

journal_title：Neuron

authors： Eaton BA,Fetter RD,Davis GW

更新日期：2002-05-30 00:00:00

abstract：:Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establis...

journal_title：Neuron

authors： Pool AH,Kvello P,Mann K,Cheung SK,Gordon MD,Wang L,Scott K

更新日期：2014-07-02 00:00:00

abstract：:Interactions between the hippocampus and prefrontal cortex (PFC) are critical for learning and memory. Hippocampal activity during awake sharp-wave ripple (SWR) events is important for spatial learning, and hippocampal SWR activity often represents past or potential future experiences. Whether or how this reactivation...

journal_title：Neuron

authors： Jadhav SP,Rothschild G,Roumis DK,Frank LM

更新日期：2016-04-06 00:00:00

abstract：:The paraventricular nucleus of the thalamus (PVT) is thought to regulate behavioral responses under emotionally arousing conditions. Reward-associated cues activate PVT neurons; however, the specific PVT efferents regulating reward seeking remain elusive. Using a cued sucrose-seeking task, we manipulated PVT activity ...

journal_title：Neuron

authors： Do-Monte FH,Minier-Toribio A,Quiñones-Laracuente K,Medina-Colón EM,Quirk GJ

更新日期：2017-04-19 00:00:00

abstract：:Compelling evidence links amyloid beta (Aβ) peptide accumulation in the brains of Alzheimer's disease (AD) patients with the emergence of learning and memory deficits, yet a clear understanding of the events that drive this synaptic pathology are lacking. We present evidence that neurons exposed to Aβ are unable to fo...

journal_title：Neuron

authors： Zhao Y,Sivaji S,Chiang MC,Ali H,Zukowski M,Ali S,Kennedy B,Sklyar A,Cheng A,Guo Z,Reed AK,Kodali R,Borowski J,Frost G,Beukema P,Wills ZP

更新日期：2017-10-11 00:00:00

abstract：:When speaking, we dynamically coordinate movements of our jaw, tongue, lips, and larynx. To investigate the neural mechanisms underlying articulation, we used direct cortical recordings from human sensorimotor cortex while participants spoke natural sentences that included sounds spanning the entire English phonetic i...

journal_title：Neuron

authors： Chartier J,Anumanchipalli GK,Johnson K,Chang EF

更新日期：2018-06-06 00:00:00

abstract：:Spontaneous fluctuations in cortical excitability influence sensory processing and behavior. These fluctuations, long thought to reflect global changes in cortical state, were recently found to be modulated locally within a retinotopic map during spatially selective attention. We report that periods of vigorous (On) a...

journal_title：Neuron

authors： van Kempen J,Gieselmann MA,Boyd M,Steinmetz NA,Moore T,Engel TA,Thiele A

更新日期：2020-12-30 00:00:00

abstract：:Membrane excitability is a fundamentally important feature for all excitable cells including both neurons and muscle cells. However, the background depolarizing conductances in excitable cells, especially in muscle cells, are not well characterized. Although mutations in transmembrane channel-like (TMC) proteins TMC1 ...

journal_title：Neuron

authors： Yue X,Zhao J,Li X,Fan Y,Duan D,Zhang X,Zou W,Sheng Y,Zhang T,Yang Q,Luo J,Duan S,Xiao R,Kang L

更新日期：2018-02-07 00:00:00

abstract：:Conditioned appetitive and aversive responses (CRs) are thought to result from the activation of specific subsets of valence-coding basolateral amygdala (BLA) neurons. Under this model, the responses of BLA cells to conditioned stimuli (CSs) and the activity that drives CRs are closely related. We tested the strength ...

journal_title：Neuron

authors： Kyriazi P,Headley DB,Pare D

更新日期：2018-09-19 00:00:00

abstract：:Neuronal microtubules support intracellular transport, facilitate axon growth, and form a basis for neuronal morphology. While microtubules in nonneuronal cells are depolymerized by cold, Ca(2+), or antimitotic drugs, neuronal microtubules are unusually stable. Such stability is important for normal axon growth and ma...

journal_title：Neuron

authors： Song Y,Kirkpatrick LL,Schilling AB,Helseth DL,Chabot N,Keillor JW,Johnson GV,Brady ST

更新日期：2013-04-10 00:00:00

abstract：:The directional selectivity of retinal ganglion cell responses represents a primitive pattern recognition that operates within a retinal neural circuit. The cellular origin and mechanism of directional selectivity were investigated by selectively eliminating retinal starburst amacrine cells, using immunotoxin-mediated...

journal_title：Neuron

authors： Yoshida K,Watanabe D,Ishikane H,Tachibana M,Pastan I,Nakanishi S

更新日期：2001-06-01 00:00:00

abstract：:Auditory receptor cells rely on mechanically gated channels to transform sound stimuli into neural activity. Several TRP channels have been implicated in Drosophila auditory transduction, but mechanistic studies have been hampered by the inability to record subthreshold signals from receptor neurons. Here, we develop ...

journal_title：Neuron

authors： Lehnert BP,Baker AE,Gaudry Q,Chiang AS,Wilson RI

更新日期：2013-01-09 00:00:00

abstract：:Both the nucleus accumbens (NAc) and basolateral amygdala (BLA) contribute to learned behavioral choice. Neurons in both structures that encode reward-predictive cues may underlie the decision to respond to such cues, but the neural circuits by which the BLA influences reward-seeking behavior have not been established...

journal_title：Neuron

authors： Ambroggi F,Ishikawa A,Fields HL,Nicola SM

更新日期：2008-08-28 00:00:00

abstract：:In this issue of Neuron, Fossati et al. (2016) report that through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitatory and inhibitory synapse development, offering a putative evolutionary genetic mechanism for preserving excitatory/inhibitory balance during speciation. ...

journal_title：Neuron

authors： Subramanian J,Nedivi E

更新日期：2016-07-20 00:00:00

abstract：:Classical patterning molecules that were previously implicated in controlling cell fate choices in the nervous system have recently been shown to play additional roles in axon guidance and synaptogenesis. Bone morphogenetic proteins (BMPs), Sonic hedgehog (Shh), Wnts, and fibroblast growth factors (FGFs) all participa...

journal_title：Neuron

authors： Salie R,Niederkofler V,Arber S

更新日期：2005-01-20 00:00:00

abstract：:mRNAs for AMPA- and kainate-preferring glutamate receptor subunits are expressed abundantly in the CNS, yet functional studies of neurons and glia from brain suggest selective expression of AMPA receptors. We now show that glial cells of the O-2A lineage express rapidly desensitizing responses to kainate, mRNAs for Gl...

journal_title：Neuron

authors： Patneau DK,Wright PW,Winters C,Mayer ML,Gallo V

更新日期：1994-02-01 00:00:00

abstract：:Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76%...

journal_title：Neuron

authors： Bozek K,Wei Y,Yan Z,Liu X,Xiong J,Sugimoto M,Tomita M,Pääbo S,Sherwood CC,Hof PR,Ely JJ,Li Y,Steinhauser D,Willmitzer L,Giavalisco P,Khaitovich P

更新日期：2015-02-18 00:00:00

abstract：:Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...

journal_title：Neuron

authors： Niethammer M,Smith DS,Ayala R,Peng J,Ko J,Lee MS,Morabito M,Tsai LH

更新日期：2000-12-01 00:00:00

abstract：:Memories are about the past, but they serve the future. Memory research often emphasizes the former aspect: focusing on the functions that re-constitute (re-member) experience and elucidating the various types of memories and their interrelations, timescales, and neural bases. Here we highlight the prospective nature ...

journal_title：Neuron

authors： Nobre AC,Stokes MG

更新日期：2019-10-09 00:00:00

abstract：:Rho GTPases are essential regulators of cytoskeletal reorganization, but how they do so during neuronal morphogenesis in vivo is poorly understood. Here we show that the actin depolymerization factor cofilin is essential for axon growth in Drosophila neurons. Cofilin function in axon growth is inhibited by LIM kinase ...

journal_title：Neuron

authors： Ng J,Luo L

更新日期：2004-12-02 00:00:00

abstract：:It has been postulated that selective temporal coordination between neurons and development of functional neuronal assemblies are fundamental for brain function and behavior. Still, there is little evidence that functionally relevant coordination emerges preferentially in neuronal assemblies directly controlling behav...

journal_title：Neuron

authors： Koralek AC,Costa RM,Carmena JM

更新日期：2013-09-04 00:00:00

abstract：:In rodents, each main olfactory bulb contains two mirror-symmetric glomerular maps, a feature not found in the initial topographic maps of other sensory systems. Targeting tracer injections to identified glomeruli revealed that isofunctional odor columns-translaminar assemblies connected to a given glomerulus-were spe...

journal_title：Neuron

authors： Lodovichi C,Belluscio L,Katz LC

更新日期：2003-04-24 00:00:00

abstract：:Local axon degeneration is a common pathological feature of many neurodegenerative diseases and peripheral neuropathies. While it is believed to operate with an apoptosis-independent molecular program, the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons,...

journal_title：Neuron

authors： Zhai Q,Wang J,Kim A,Liu Q,Watts R,Hoopfer E,Mitchison T,Luo L,He Z

更新日期：2003-07-17 00:00:00

abstract：:Neuropathic pain is caused by long-term modifications of neuronal function in the peripheral nervous system, the spinal cord, and supraspinal areas. Although functional changes in the forebrain are thought to contribute to the development of persistent pain, their significance and precise subcellular nature remain une...

journal_title：Neuron

authors： Santello M,Nevian T

更新日期：2015-04-08 00:00:00