Abstract:
:To assess the necessary parameters for the growth of axons within the adult rat CNS, we have used intracerebral grafts of primary fibroblasts genetically engineered to express nerve growth factor (NGF). Following the implantation of NGF-producing primary fibroblasts within the striatum, cholinergic axons arising from the nucleus basalis grow toward and penetrate these grafts between 1 and 8 weeks. Grafts of noninfected control cells do not elicit axon sprouting at any time. Unmyelinated axons grow into grafts of NGF-producing cells only on reactive astrocytic processes, which contribute to a surrounding glial border. From our data concerning axon growth within the adult rat CNS, we conclude that reactive astrocytes can act as conducive substrates for growing axons; and only in the presence of elevated levels of NGF will permissive substrates (e.g., astrocytes) support axon growth by NGF-sensitive neurons.
journal_name
Neuronjournal_title
Neuronauthors
Kawaja MD,Gage FHdoi
10.1016/0896-6273(91)90346-2subject
Has Abstractpub_date
1991-12-01 00:00:00pages
1019-30issue
6eissn
0896-6273issn
1097-4199pii
0896-6273(91)90346-2journal_volume
7pub_type
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