Abstract：
:The development of GABAergic inhibitory circuits is shaped by neural activity, but the underlying mechanisms are unclear. Here, we demonstrate a novel function of GABA in regulating GABAergic innervation in the adolescent brain, when GABA is mainly known as an inhibitory transmitter. Conditional knockdown of the rate-limiting synthetic enzyme GAD67 in basket interneurons in adolescent visual cortex resulted in cell autonomous deficits in axon branching, perisomatic synapse formation around pyramidal neurons, and complexity of the innervation fields; the same manipulation had little influence on the subsequent maintenance of perisomatic synapses. These effects of GABA deficiency were rescued by suppressing GABA reuptake and by GABA receptor agonists. Germline knockdown of GAD67 but not GAD65 showed similar deficits, suggesting a specific role of GAD67 in the maturation of perisomatic innervation. Since intracellular GABA levels are modulated by neuronal activity, our results implicate GAD67-mediated GABA synthesis in activity-dependent regulation of inhibitory innervation patterns.
journal_name
Neuronjournal_title
Neuronauthors
Chattopadhyaya B,Di Cristo G,Wu CZ,Knott G,Kuhlman S,Fu Y,Palmiter RD,Huang ZJdoi
10.1016/j.neuron.2007.05.015subject
Has Abstractpub_date
2007-06-21 00:00:00pages
889-903issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(07)00372-8journal_volume
54pub_type
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