Temporal integration of olfactory perceptual evidence in human orbitofrontal cortex.

abstract：:Serotonergic neurons are thought to play a role in depression and obsessive compulsive disorder. However, their functional transmitter repertoire is incompletely known. To investigate this repertoire, intracellular recordings were obtained from 132 cytochemically identified rat mesopontine serotonergic neurons that ha...

journal_title：Neuron

authors： Johnson MD

更新日期：1994-02-01 00:00:00

abstract：:It is well established that the intraparietal sulcus (IPS) plays an important role in the processing and representation of numerical magnitude. Two recent studies by Piazza et al. and Cohen Kadosh et al. published in this issue of Neuron used fMRI adaptation to explore the extent to which parietal number processing is...

journal_title：Neuron

authors： Ansari D

更新日期：2007-01-18 00:00:00

abstract：:Microglia are the immune cells of the brain. Here we show a massive infiltration of highly ramified and elongated microglia within the core of amyloid plaques in transgenic mouse models of Alzheimer's disease (AD). Many of these cells originate from the bone marrow, and the beta-amyloid-40 and -42 isoforms are able to...

journal_title：Neuron

authors： Simard AR,Soulet D,Gowing G,Julien JP,Rivest S

更新日期：2006-02-16 00:00:00

abstract：:We recently proposed that ciliary neurotrophic factor (CNTF) shares two receptor components with a generally acting cytokine, leukemia inhibitory factor (LIF), but that CNTF also requires a third receptor component (CNTFR alpha) that is mostly restricted to the nervous system in its expression. Here we demonstrate tha...

journal_title：Neuron

authors： Ip NY,McClain J,Barrezueta NX,Aldrich TH,Pan L,Li Y,Wiegand SJ,Friedman B,Davis S,Yancopoulos GD

更新日期：1993-01-01 00:00:00

abstract：:The precise subunit composition of synaptic ionotropic receptors in the brain is poorly understood. This information is of particular importance with regard to AMPA-type glutamate receptors, the multimeric complexes assembled from GluA1-A4 subunits, as the trafficking of these receptors into and out of synapses is pro...

journal_title：Neuron

authors： Lu W,Shi Y,Jackson AC,Bjorgan K,During MJ,Sprengel R,Seeburg PH,Nicoll RA

更新日期：2009-04-30 00:00:00

abstract：:Sensory experience plays an instructive role in the development of the nervous system. Here we showed that visual experience can induce persistent modification of developing retinotectal circuits via spike timing-dependent plasticity (STDP). Pairing light stimuli with spiking of the tectal cell induced persistent enha...

journal_title：Neuron

authors： Mu Y,Poo MM

更新日期：2006-04-06 00:00:00

abstract：:Dopamine (DA) transmission mediates numerous aspects of behavior. Although DA release is strongly linked to firing of DA neurons, recent developments indicate the importance of presynaptic modulation at striatal dopaminergic terminals. The endocannabinoid (eCB) system regulates DA release and is a canonical gatekeeper...

journal_title：Neuron

authors： Mateo Y,Johnson KA,Covey DP,Atwood BK,Wang HL,Zhang S,Gildish I,Cachope R,Bellocchio L,Guzmán M,Morales M,Cheer JF,Lovinger DM

更新日期：2017-12-06 00:00:00

abstract：:People are embedded in social interaction that shapes their brains throughout lifetime. Instead of emerging from lower-level cognitive functions, social interaction could be the default mode via which humans communicate with their environment. Should this hypothesis be true, it would have profound implications on how ...

journal_title：Neuron

authors： Hari R,Henriksson L,Malinen S,Parkkonen L

更新日期：2015-10-07 00:00:00

abstract：:Studies of the innervation of limb muscles by spinal motor neurons have helped to define mechanisms by which axons establish trajectories to their targets. Related motor axons select dorsal or ventral pathways at the base of the limb, raising the question of how these alternate trajectories are specified. EphA signali...

journal_title：Neuron

authors： Luria V,Krawchuk D,Jessell TM,Laufer E,Kania A

更新日期：2008-12-26 00:00:00

abstract：:Dscam1 potentially encodes 19,008 ectodomains of a cell recognition molecule of the immunoglobulin (Ig) superfamily through alternative splicing. Each ectodomain, comprising a unique combination of three variable (Ig) domains, exhibits isoform-specific homophilic binding in vitro. Although we have proposed that the ab...

journal_title：Neuron

authors： Wu W,Ahlsen G,Baker D,Shapiro L,Zipursky SL

更新日期：2012-04-26 00:00:00

abstract：:Secretion principles are conserved from yeast to humans, and many yeast orthologs have established roles in synaptic vesicle exocytosis in the mammalian brain. Surprisingly, SEC4 orthologs and their effectors, the exocyst, are dispensable for synaptic vesicle exocytosis. Here, we identify the SEC4 ortholog RAB3 and it...

journal_title：Neuron

authors： Persoon CM,Hoogstraaten RI,Nassal JP,van Weering JRT,Kaeser PS,Toonen RF,Verhage M

更新日期：2019-12-18 00:00:00

abstract：:While there are selective regions of occipitotemporal cortex that respond to faces, letters, and bodies, the large-scale neural organization of most object categories remains unknown. Here, we find that object representations can be differentiated along the ventral temporal cortex by their real-world size. In a functi...

journal_title：Neuron

authors： Konkle T,Oliva A

更新日期：2012-06-21 00:00:00

abstract：:Olfactory receptor neurons (ORNs) transform scant chemical inputs into significant neural signals. This transformation requires signal amplification. In this issue of Neuron, Ng et al. (2019) identified a mechanism by which the signals evoked by pheromones are amplified in the ORNs that selectively promote courtship b...

journal_title：Neuron

authors： Kim BS,Suh GSB

更新日期：2019-12-04 00:00:00

abstract：:A new study by Yao et al. in the current issue of Cell proposes that a novel vesicular protein, dubbed Flower, regulates endocytosis by controlling presynaptic Ca(2+) levels. This finding is intriguing not only for its implications for vesicle cycling, but also for the multitude of Ca(2+)-dependent processes at play i...

journal_title：Neuron

authors： Kuo SP,Trussell LO

更新日期：2009-09-10 00:00:00

abstract：:The alpha subunit of a voltage-sensitive sodium channel characteristic of denervated rat skeletal muscle was cloned and characterized. The cDNA encodes a 2018 amino acid protein (SkM2) that is homologous to other recently cloned sodium channels, including a tetrodotoxin (TTX)-sensitive sodium channel from rat skeletal...

journal_title：Neuron

authors： Kallen RG,Sheng ZH,Yang J,Chen LQ,Rogart RB,Barchi RL

更新日期：1990-02-01 00:00:00

abstract：:Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion i...

journal_title：Neuron

authors： Orr HT

更新日期：2011-10-20 00:00:00

abstract：:Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...

journal_title：Neuron

authors： Quinlan EM,Lebel D,Brosh I,Barkai E

更新日期：2004-01-22 00:00:00

abstract：:Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and expli...

journal_title：Neuron

authors： Plath N,Ohana O,Dammermann B,Errington ML,Schmitz D,Gross C,Mao X,Engelsberg A,Mahlke C,Welzl H,Kobalz U,Stawrakakis A,Fernandez E,Waltereit R,Bick-Sander A,Therstappen E,Cooke SF,Blanquet V,Wurst W,Salmen B,Bösl

更新日期：2006-11-09 00:00:00

abstract：:Adaptation or gain control allows sensory neurons to encode diverse stimuli using a limited range of output signals. Rod vision exemplifies a general challenge facing adaptational mechanisms-balancing the benefits of averaging to create a reliable signal for adaptation with the need to adapt rapidly and locally. The s...

journal_title：Neuron

authors： Dunn FA,Rieke F

更新日期：2008-03-27 00:00:00

abstract：:Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits. ...

journal_title：Neuron

authors： Udeochu J,Sayed FA,Gan L

更新日期：2018-03-07 00:00:00

abstract：:The neurotrophic proteins BDNF and NGF are related in their primary structures, and both have high- and low-affinity receptors on their responsive neurons. In this study, we investigate the extent to which these receptors can discriminate between BDNF and NGF. We found that a 1000-fold excess of the heterologous ligan...

journal_title：Neuron

authors： Rodriguez-Tébar A,Dechant G,Barde YA

更新日期：1990-04-01 00:00:00

abstract：:During normal vision, the focus of gaze continually jumps from one important image feature to the next. In this issue of Neuron, Mazer and Gallant analyze neural activity in higher-level visual cortex during this kind of active visual exploration, and they demonstrate a localized enhancement of visual responses that p...

journal_title：Neuron

authors： Connor CE

更新日期：2003-12-18 00:00:00

abstract：:A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a key regulatory event in the "neural decision" to undergo these p...

journal_title：Neuron

authors： Hoeffer CA,Klann E

更新日期：2007-04-19 00:00:00

abstract：:Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding process...

journal_title：Neuron

authors： Kounios J,Smith RW,Yang W,Bachman P,D'Esposito M

更新日期：2001-01-01 00:00:00

abstract：:Hippocampal dentate granule cell abnormalities are thought to play a causative role in temporal lobe epilepsy, but their precise contribution has not been dissociated from coexisting pathological changes. In this issue of Neuron, Pun et al. (2012) show, for the first time, that inducing proexcitatory changes in a subs...

journal_title：Neuron

authors： Althaus AL,Parent JM

更新日期：2012-09-20 00:00:00

abstract：:Each odorant receptor gene defines a unique type of olfactory receptor neuron (ORN) and a corresponding type of second-order neuron. Because each odor can activate multiple ORN types, information must ultimately be integrated across these processing channels to form a unified percept. Here, we show that, in Drosophila...

journal_title：Neuron

authors： Olsen SR,Bhandawat V,Wilson RI

更新日期：2007-04-05 00:00:00

abstract：:The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcriptio...

journal_title：Neuron

authors： Nicolas CS,Peineau S,Amici M,Csaba Z,Fafouri A,Javalet C,Collett VJ,Hildebrandt L,Seaton G,Choi SL,Sim SE,Bradley C,Lee K,Zhuo M,Kaang BK,Gressens P,Dournaud P,Fitzjohn SM,Bortolotto ZA,Cho K,Collingridge GL

更新日期：2012-01-26 00:00:00

abstract：:Music can be seen as a model system for understanding gene × environment interactions and how these can influence neurocognitive development. The concept of musicality, however, is underspecified and not well understood. Here, I propose a framework for defining musicality to provide a foundation for studying the contr...

journal_title：Neuron

authors： Levitin DJ

更新日期：2012-02-23 00:00:00

abstract：:Ephrin signaling through Eph receptor tyrosine kinases can promote attraction or repulsion of axonal growth cones during development. However, the mechanisms that determine whether Eph signaling promotes attraction or repulsion are not known. We show here that the Rho family GEF Vav2 plays a key role in this process. ...

journal_title：Neuron

authors： Cowan CW,Shao YR,Sahin M,Shamah SM,Lin MZ,Greer PL,Gao S,Griffith EC,Brugge JS,Greenberg ME

更新日期：2005-04-21 00:00:00

abstract：:Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional...

journal_title：Neuron

authors： Wager TD,Davidson ML,Hughes BL,Lindquist MA,Ochsner KN

更新日期：2008-09-25 00:00:00