Abstract:
:Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion in C90RF72. These studies, plus a study on X-linked ALS/FTD, provide molecular starting points for identifying pathways that link ALS and FTD pathogenesis.
journal_name
Neuronjournal_title
Neuronauthors
Orr HTdoi
10.1016/j.neuron.2011.10.001subject
Has Abstractpub_date
2011-10-20 00:00:00pages
189-90issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(11)00880-4journal_volume
72pub_type
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