FTD and ALS: genetic ties that bind.

Abstract:

:Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion in C90RF72. These studies, plus a study on X-linked ALS/FTD, provide molecular starting points for identifying pathways that link ALS and FTD pathogenesis.

journal_name

Neuron

journal_title

Neuron

authors

Orr HT

doi

10.1016/j.neuron.2011.10.001

subject

Has Abstract

pub_date

2011-10-20 00:00:00

pages

189-90

issue

2

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(11)00880-4

journal_volume

72

pub_type

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