Abstract：
:During development, retinal ganglion cell (RGC) axons either cross or avoid the midline at the optic chiasm. In Drosophila, the Slit protein regulates midline axon crossing through repulsion. To determine the role of Slit proteins in RGC axon guidance, we disrupted Slit1 and Slit2, two of three known mouse Slit genes. Mice defective in either gene alone exhibited few RGC axon guidance defects, but in double mutant mice a large additional chiasm developed anterior to the true chiasm, many retinal axons projected into the contralateral optic nerve, and some extended ectopically-dorsal and lateral to the chiasm. Our results indicate that Slit proteins repel retinal axons in vivo and cooperate to establish a corridor through which the axons are channeled, thereby helping define the site in the ventral diencephalon where the optic chiasm forms.
journal_name
Neuronjournal_title
Neuronauthors
Plump AS,Erskine L,Sabatier C,Brose K,Epstein CJ,Goodman CS,Mason CA,Tessier-Lavigne Mdoi
10.1016/s0896-6273(01)00586-4subject
Has Abstractpub_date
2002-01-17 00:00:00pages
219-32issue
2eissn
0896-6273issn
1097-4199pii
S0896627301005864journal_volume
33pub_type
杂志文章相关文献
NEURON文献大全abstract：:Using exome sequencing, we identified a p.R191Q amino acid change in the valosin-containing protein (VCP) gene in an Italian family with autosomal dominantly inherited amyotrophic lateral sclerosis (ALS). Mutations in VCP have previously been identified in families with Inclusion Body Myopathy, Paget disease, and Fron...
journal_title：Neuron
pub_type： 杂志文章,多中心研究
doi：10.1016/j.neuron.2010.11.036
更新日期：2010-12-09 00:00:00
abstract：:Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.09.025
更新日期：2018-11-21 00:00:00
abstract：:In rodents, each main olfactory bulb contains two mirror-symmetric glomerular maps, a feature not found in the initial topographic maps of other sensory systems. Targeting tracer injections to identified glomeruli revealed that isofunctional odor columns-translaminar assemblies connected to a given glomerulus-were spe...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00194-6
更新日期：2003-04-24 00:00:00
abstract：:Altered microRNA profiles have been implicated in human brain disorders. However, the functional contribution of individual microRNAs to neuronal development and function is largely unknown. Here, we report biological functions for miR-19 in adult neurogenesis. We determined that miR-19 is enriched in neural progenito...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.05.034
更新日期：2016-07-06 00:00:00
abstract：:It is well established that the intraparietal sulcus (IPS) plays an important role in the processing and representation of numerical magnitude. Two recent studies by Piazza et al. and Cohen Kadosh et al. published in this issue of Neuron used fMRI adaptation to explore the extent to which parietal number processing is...
journal_title：Neuron
pub_type： 评论,社论,评审
doi：10.1016/j.neuron.2007.01.001
更新日期：2007-01-18 00:00:00
abstract：:In addition to the classical, center/surround receptive field of neurons in the lateral geniculate nucleus (LGN), there is an extraclassical, nonlinear surround that can strongly suppress LGN responses. This form of suppression likely plays an important role in adjusting the gain of LGN responses to visual stimuli. We...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.11.019
更新日期：2008-01-10 00:00:00
abstract：:In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.04.034
更新日期：2016-06-01 00:00:00
abstract：:A proposal for an Australian Brain Initiative (ABI) is under development by members of the Australian Brain Alliance. Here we discuss the goals of the ABI, its areas of research focus, its context in the Australian research setting, and its necessity for ensuring continued success for Australian brain research. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.10.038
更新日期：2016-11-02 00:00:00
abstract：:We describe a reaggregated cell culture system in which retinal neuroepithelial cells from embryonic rats proliferate extensively and give rise to rod photoreceptors on the same schedule in vitro as they do in vivo. Both the proliferative potential of the embryonic neuroepithelial cells and the timing of their differe...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90058-n
更新日期：1990-03-01 00:00:00
abstract：:The brain is a vulnerable metabolic organ and must adapt to different fuel conditions to sustain function. Nerve terminals are a locus of this vulnerability, but how they regulate ATP synthesis as fuel conditions vary is unknown. We show that synapses can switch from glycolytic to oxidative metabolism, but to do so, t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.11.020
更新日期：2020-02-19 00:00:00
abstract：:Commissural axons are attracted to the midline intermediate target by chemoattractants, but upon crossing the midline they switch off responsiveness to attractants and switch on responsiveness to midline repellents, which expel the axons from the midline and enable them to move on. Here we show that midline exit also ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.01.006
更新日期：2008-02-28 00:00:00
abstract：:To achieve simultaneous measurement of multiple cellular events in molecularly defined groups of neurons in vivo, we designed a spectrometer-based fiber photometry system that allows for spectral unmixing of multiple fluorescence signals recorded from deep brain structures in behaving animals. Using green and red Ca2+...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.04.012
更新日期：2018-05-16 00:00:00
abstract：:Using somatic cell nuclear transfer, Hazen et al. (2016) examined clonally expanded single neurons for mutations and found ∼100 mutations from a variety of classes. Post-mitotic mutations in individual neurons represent an exploratory direction for finding fundamental origins of neurodegeneration. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2016.02.042
更新日期：2016-03-16 00:00:00
abstract：:S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group on the target protein. Under physiological conditions, S-nitrosylation can be an important modulator of signal transduction pathways,...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2013.05.005
更新日期：2013-05-22 00:00:00
abstract：:Dendritic structure critically determines the electrical properties of neurons and, thereby, defines the fundamental process of input-to-output conversion. The diversity of dendritic architectures enables neurons to fulfill their specialized circuit functions during cognitive processes. It is known that this dendritic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.10.024
更新日期：2014-12-03 00:00:00
abstract：:Neuropilins are receptors for class 3 secreted semaphorins, most of which can function as potent repulsive axon guidance cues. We have generated mice with a targeted deletion in the neuropilin-2 (Npn-2) locus. Many Npn-2 mutant mice are viable into adulthood, allowing us to assess the role of Npn-2 in axon guidance ev...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80869-7
更新日期：2000-01-01 00:00:00
abstract：:The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Car...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.03.017
更新日期：2016-05-04 00:00:00
abstract：:Phosphorylation of brain Na+ channels by protein kinase C (PKC) decreases peak Na+ current and slows macroscopic inactivation, but receptor-activated modulation of Na+ currents via the PKC pathway has not been demonstrated. We have examined modulation of Na+ channels by activation of muscarinic receptors in acutely-is...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80125-7
更新日期：1996-05-01 00:00:00
abstract：:Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excito...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/s0896-6273(02)00631-1
更新日期：2002-03-14 00:00:00
abstract：:Quaternary ammonium (QA) compounds inhibit K+ conductance by entering and occluding the open pore of voltage-activated K+ channels. We characterized the effects of a series of alkyl-triethylammonium blockers on the Shaker K+ channel and tested them on a series of site-directed mutants of the channel protein in order t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90340-w
更新日期：1993-03-01 00:00:00
abstract：:The peripheral terminals of primary nociceptive neurons play an essential role in pain detection mediated by membrane receptors like TRPV1, a molecular sensor of heat and capsaicin. However, the contribution of central terminal TRPV1 in the dorsal horn to chronic pain has not been investigated directly. Combining prim...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.12.011
更新日期：2014-02-19 00:00:00
abstract：:In vivo optogenetics provides unique, powerful capabilities in the dissection of neural circuits implicated in neuropsychiatric disorders. Conventional hardware for such studies, however, physically tethers the experimental animal to an external light source, limiting the range of possible experiments. Emerging wirele...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.12.031
更新日期：2017-02-08 00:00:00
abstract：:To define the cis-acting DNA elements required for rhodopsin expression, we generated lines of transgenic mice carrying sequences upstream of the bovine rhodopsin gene fused to the E. coli beta-galactosidase gene (lacZ). Upstream sequences extending from -2174 to +70 bp, from -734 to +70 bp, and from -222 to +70 bp di...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(91)90355-4
更新日期：1991-02-01 00:00:00
abstract：:Agonist-induced suppression of current in voltage-gated Ca2+ channels was studied in rat sympathetic neurons. We have previously distinguished two intracellular signaling pathways used by muscarinic agonists to suppress neuronal Ca2+ current-one fast and membrane delimited, the other slow and acting via a diffusible s...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90111-p
更新日期：1992-01-01 00:00:00
abstract：:Modification of AMPA receptor function is a major mechanism for the regulation of synaptic transmission and underlies several forms of synaptic plasticity. Post-translational palmitoylation is a reversible modification that regulates localization of many proteins. Here, we report that palmitoylation of the AMPA recept...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.06.035
更新日期：2005-09-01 00:00:00
abstract：:The release of neurotransmitter-filled vesicles after action potentials occurs with discrete time courses: submillisecond phasic release that can be desynchronized by activity followed by "delayed release" that persists for tens of milliseconds. Delayed release has a well-established role in synaptic integration, but ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.03.029
更新日期：2011-06-09 00:00:00
abstract：:Acetylcholine release in the prefrontal cortex (PFC), acting through muscarinic receptors, has an essential role in regulating flexible behavior and working memory (WM). General muscarinic receptor blockade disrupts PFC WM representations, while selective stimulation of muscarinic receptor subtypes is of great interes...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.05.027
更新日期：2018-06-27 00:00:00
abstract：:GABAb receptor (GABAbR)-mediated suppression of glutamate release is critical for limiting glutamatergic transmission across the central nervous system (CNS). Here we show that, upon tetanic stimulation of afferents to lateral amygdala, presynaptic GABAbR-mediated inhibition only occurs in glutamatergic inputs to prin...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.01.029
更新日期：2009-03-26 00:00:00
abstract：:At the optic chiasm, axons from either eye meet and decide whether to cross contralaterally or turn back ipsilaterally. Here, the guidance ligand Slit and its receptor Robo control not whether axons cross (as in other midline decisions), but where the chiasm forms. Whether axons cross is instead controlled by the tran...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(03)00563-4
更新日期：2003-09-11 00:00:00
abstract：:Receptor tyrosine kinases (RTKs) are membrane spanning proteins with intrinsic kinase activity. Although these receptors are known to be involved in proliferation and differentiation of cells, their roles in regulating central synaptic transmission are largely unknown. In CA1 pyramidal neurons, activation of D2 class ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00859-0
更新日期：2002-09-12 00:00:00
