Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain.

abstract：:Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin (mHTT) protein. There are currently no disease-modifying therapies available, but approaches that target proximally in disease pathogenesis hold gre...

journal_title：Neuron

authors： Tabrizi SJ,Ghosh R,Leavitt BR

更新日期：2019-03-06 00:00:00

abstract：:A multitude of synaptic proteins interact at the active zones of nerve terminals to achieve the high temporal precision of neurotransmitter release in synchrony with action potentials. Though synaptotagmin has been recognized as the Ca2+ sensor for synchronous release, it may have additional roles of action. We addres...

journal_title：Neuron

authors： Young SM Jr,Neher E

更新日期：2009-08-27 00:00:00

abstract：:For efficient coding, sensory systems need to adapt to the distribution of signals to which they are exposed. In vision, natural scenes above and below the horizon differ in the distribution of chromatic and achromatic features. Consequently, many species differentially sample light in the sky and on the ground using ...

journal_title：Neuron

authors： Baden T,Schubert T,Chang L,Wei T,Zaichuk M,Wissinger B,Euler T

更新日期：2013-12-04 00:00:00

abstract：:The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we exami...

journal_title：Neuron

authors： Smith AP,Stephan KE,Rugg MD,Dolan RJ

更新日期：2006-02-16 00:00:00

abstract：:The M current regulates neuronal excitability, with its amplitude resulting from high open probability modal M channel behavior. The M current is affected by changing intracellular calcium levels. It is proposed that internal calcium acts by regulating M channel modal gating. Intracellular application of a preactivate...

journal_title：Neuron

authors： Marrion NV

更新日期：1996-01-01 00:00:00

abstract：:In this issue of Neuron, Ajemian et al. present a computational model of the activity of neurons in primary motor cortex (M1) during isometric movements in different postures. By modeling the output of M1 neurons in terms of their influence on muscles, they find each M1 neuron maps its output into a particular pattern...

journal_title：Neuron

authors： Pesaran B,Movshon JA

更新日期：2008-05-08 00:00:00

abstract：:Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establis...

journal_title：Neuron

authors： Pool AH,Kvello P,Mann K,Cheung SK,Gordon MD,Wang L,Scott K

更新日期：2014-07-02 00:00:00

abstract：:Simple decisions arise from the evaluation of sensory evidence. But decisions are determined by more than just evidence. Individuals establish internal decision criteria that influence how they respond. Where or how decision criteria are established in the brain remains poorly understood. Here, we show that neuronal a...

journal_title：Neuron

authors： Crapse TB,Lau H,Basso MA

更新日期：2018-01-03 00:00:00

abstract：:Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique conformations ("strains") in vivo that link structure to patterns of pathology. We now find that tau meets this criterion. Stably expressed tau repeat domain indefin...

journal_title：Neuron

authors： Sanders DW,Kaufman SK,DeVos SL,Sharma AM,Mirbaha H,Li A,Barker SJ,Foley AC,Thorpe JR,Serpell LC,Miller TM,Grinberg LT,Seeley WW,Diamond MI

更新日期：2014-06-18 00:00:00

abstract：:Immunophilins, including FK506-binding proteins (FKBPs), are protein chaperones with peptidyl-prolyl isomerase (PPIase) activity. Initially identified as pharmacological receptors for immunosuppressants to regulate immune responses via isomerase-independent mechanisms, FKBPs are most highly expressed in the nervous sy...

journal_title：Neuron

authors： Shim S,Yuan JP,Kim JY,Zeng W,Huang G,Milshteyn A,Kern D,Muallem S,Ming GL,Worley PF

更新日期：2009-11-25 00:00:00

abstract：:Membrane depolarization causes voltage-gated ion channels to transition from a resting/closed conformation to an activated/open conformation. We used voltage-clamp fluorometry to measure protein motion at specific regions of the Shaker Kv channel. This enabled us to construct new structural models of the resting/close...

journal_title：Neuron

authors： Pathak MM,Yarov-Yarovoy V,Agarwal G,Roux B,Barth P,Kohout S,Tombola F,Isacoff EY

更新日期：2007-10-04 00:00:00

abstract：:In the long-range neuronal migration of adult mammals, young neurons travel from the subventricular zone to the olfactory bulb, a long journey (millimeters to centimeters, depending on the species). How can these neurons migrate through the dense meshwork of neuronal and glial processes of the adult brain parenchyma? ...

journal_title：Neuron

authors： Kaneko N,Marín O,Koike M,Hirota Y,Uchiyama Y,Wu JY,Lu Q,Tessier-Lavigne M,Alvarez-Buylla A,Okano H,Rubenstein JL,Sawamoto K

更新日期：2010-07-29 00:00:00

abstract：:Human confidence judgments are thought to originate from metacognitive processes that provide a subjective assessment about one's beliefs. Alternatively, confidence is framed in mathematics as an objective statistical quantity: the probability that a chosen hypothesis is correct. Despite similar terminology, it remain...

journal_title：Neuron

authors： Sanders JI,Hangya B,Kepecs A

更新日期：2016-05-04 00:00:00

abstract：:During development of the mammalian nervous system, neural stem cells generate neurons first and glia second, thereby allowing the initial establishment of neural circuitry, and subsequent matching of glial numbers and position to that circuitry. Here, we have reviewed work addressing the mechanisms underlying this ti...

journal_title：Neuron

authors： Miller FD,Gauthier AS

更新日期：2007-05-03 00:00:00

abstract：:The distribution of the synaptic vesicle-associated phosphoprotein synapsin I after electrical stimulation of the frog neuromuscular junction was investigated by immunogold labeling and compared with the distribution of the integral synaptic vesicle protein synaptophysin. In resting terminals both proteins were locali...

journal_title：Neuron

authors： Torri Tarelli F,Bossi M,Fesce R,Greengard P,Valtorta F

更新日期：1992-12-01 00:00:00

abstract：:Lissencephaly (LIS), denoting a "smooth brain," is characterized by the absence of normal cerebral convolutions with abnormalities of cortical thickness. Pathogenic variants in over 20 genes are associated with LIS. The majority of posterior predominant LIS is caused by pathogenic variants in LIS1 (also known as PAFAH...

journal_title：Neuron

authors： Tsai MH,Muir AM,Wang WJ,Kang YN,Yang KC,Chao NH,Wu MF,Chang YC,Porter BE,Jansen LA,Sebire G,Deconinck N,Fan WL,Su SC,Chung WH,Almanza Fuerte EP,Mehaffey MG,University of Washington Center for Mendelian Genomics.,Ng CC

更新日期：2020-04-22 00:00:00

abstract：:Despite the best available medical treatments, many patients continue to be disabled by neurologic and psychiatric disorders, resulting in a large unmet need. Advances in imaging and neurophysiology over the last two decades have led to a reinterpretation of some neurologic and psychiatric conditions as primarily diso...

journal_title：Neuron

authors： Lozano AM,Lipsman N

更新日期：2013-02-06 00:00:00

abstract：:Under ambient air conditions, NO inhibits NMDAR activity by reacting with the NR2A subunit C399 along with two additional cysteine pairs if their disulfide bonds are reduced to free thiol groups [NR1(C744,C798); NR2(C87,C320)]. Here we demonstrate that relative hypoxia enhances S-nitrosylation of NMDARs by a unique me...

journal_title：Neuron

authors： Takahashi H,Shin Y,Cho SJ,Zago WM,Nakamura T,Gu Z,Ma Y,Furukawa H,Liddington R,Zhang D,Tong G,Chen HS,Lipton SA

更新日期：2007-01-04 00:00:00

abstract：:When faced with a crowded visual scene, observers must selectively attend to behaviorally relevant objects to avoid sensory overload. Often this selection process is guided by prior knowledge of a target-defining feature (e.g., the color red when looking for an apple), which enhances the firing rate of visual neurons ...

journal_title：Neuron

authors： Serences JT,Boynton GM

更新日期：2007-07-19 00:00:00

abstract：:Glial cells respond to neuronal activation and release neuroactive molecules (termed "gliotransmitters") that can affect synaptic activity and modulate plasticity. In this study, we used molecular genetic tools, ultra-structural microscopy, and electrophysiology to assess the role of brain-derived neurotrophic factor ...

journal_title：Neuron

authors： Vignoli B,Battistini G,Melani R,Blum R,Santi S,Berardi N,Canossa M

更新日期：2016-11-23 00:00:00

abstract：:Sympathetic neurons in culture die by apoptosis when deprived of nerve growth factor (NGF). We used this model of programmed cell death to study the mechanisms that mediate neuronal apoptosis. Cultured sympathetic neurons were injected with copper/zinc superoxide dismutase protein (SOD) or with an expression vector co...

journal_title：Neuron

authors： Greenlund LJ,Deckwerth TL,Johnson EM Jr

更新日期：1995-02-01 00:00:00

abstract：:LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins. Surprisingly, nervous system development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial learning, alterations in LTP, and abnormalities in hippocampal dendritic spine structure. The findings ar...

journal_title：Neuron

authors： Sarmiere PD,Bamburg JR

更新日期：2002-07-03 00:00:00

abstract：:Neural processing at most stages of the primate visual system is modulated by selective attention, such that behaviorally relevant information is emphasized at the expenses of irrelevant, potentially distracting information. The form of attention best understood at the cellular level is when stimuli at a given locatio...

journal_title：Neuron

authors： Mirabella G,Bertini G,Samengo I,Kilavik BE,Frilli D,Della Libera C,Chelazzi L

更新日期：2007-04-19 00:00:00

abstract：:NMDA receptor subunit composition varies throughout the brain, providing molecular diversity in NMDA receptor function. The NR2 subunits (NR2A-D) in large part dictate the distinct functional properties of NMDA receptors and differentially regulate receptor trafficking. Although the NR2C subunit is highly enriched in ...

journal_title：Neuron

authors： Chen BS,Roche KW

更新日期：2009-05-28 00:00:00

abstract：:Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In contrast to these animal models, most human narcolepsy is not familial, is discordant in identical twins, and has not been linked to mutations of the Hcrt system. Thus, the cause of human narc...

journal_title：Neuron

authors： Thannickal TC,Moore RY,Nienhuis R,Ramanathan L,Gulyani S,Aldrich M,Cornford M,Siegel JM

更新日期：2000-09-01 00:00:00

abstract：:Injection of inositol 1,4,5 trisphosphate (InsP3) into Limulus ventral photoreceptors elevates the concentration of intracellular calcium ions and as a consequence depolarizes the photoreceptor. This InsP3-induced elevation can be inhibited by a prior injection of calcium or InsP3 delivered 1 s earlier. Recovery from ...

journal_title：Neuron

authors： Payne R,Flores TM,Fein A

更新日期：1990-04-01 00:00:00

abstract：:Spike timing-dependent synaptic plasticity (STDP) serves as a key cellular correlate of associative learning, which is facilitated by elevated attentional and emotional states involving activation of adrenergic signaling. At cellular levels, adrenergic signaling increases dendrite excitability, but the underlying mech...

journal_title：Neuron

authors： Liu Y,Cui L,Schwarz MK,Dong Y,Schlüter OM

更新日期：2017-01-18 00:00:00

abstract：:Modulation of evoked quantal transmitter release by protein kinase C (PKC) was investigated at an identified cholinergic neuro-neuronal synapse of the Aplysia buccal ganglion. Evoked acetylcholine release was increased by a diacylglycerol analog that activates PKC and was decreased by H-7, a blocker of PKC. FLRFamide ...

journal_title：Neuron

authors： Fossier P,Baux G,Tauc L

更新日期：1990-10-01 00:00:00

abstract：:Changes in intracellular calcium (Ca) concentration following synaptic and suprathreshold activity are mediated by a wide range of sources and contribute to the regulation of myriad neuronal functions. The development of Ca imaging techniques has dramatically increased our understanding of the complex interactions bet...

journal_title：Neuron

authors： Higley MJ,Sabatini BL

更新日期：2008-09-25 00:00:00

abstract：:I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer subunits are compared to those with linked subunits that force defined stoichiometries. Two strategies that exploit charybd...

journal_title：Neuron

authors： Chen H,Kim LA,Rajan S,Xu S,Goldstein SA

更新日期：2003-09-25 00:00:00