Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor.

abstract：:Respiration is a rhythmic activity as well as one that requires responsiveness to internal and external circumstances; both the rhythm and neuromodulatory responses of breathing are controlled by brainstem neurons in the preBötzinger complex (preBötC) and the retrotrapezoid nucleus (RTN), but the specific ion channels...

journal_title：Neuron

authors： Yeh SY,Huang WH,Wang W,Ward CS,Chao ES,Wu Z,Tang B,Tang J,Sun JJ,Esther van der Heijden M,Gray PA,Xue M,Ray RS,Ren D,Zoghbi HY

更新日期：2017-04-19 00:00:00

abstract：:Although many studies have identified neural correlates of memory, relatively little is known about the circuit properties connecting single-neuron physiology to behavior. Here we developed a modeling framework to bridge this gap and identify circuit interactions capable of maintaining short-term memory. Unlike typica...

journal_title：Neuron

authors： Fisher D,Olasagasti I,Tank DW,Aksay ER,Goldman MS

更新日期：2013-09-04 00:00:00

abstract：:In this issue of Neuron, Rinberg et al. show that mice use a speed-accuracy tradeoff in odor discrimination. Shorter sampling results in high performance for easy problems, and enforced longer sampling results in higher accuracy for difficult problems, but mice freely choose intermediate sampling durations and accurac...

journal_title：Neuron

authors： Kay LM,Beshel J,Martin C

更新日期：2006-08-03 00:00:00

abstract：:The differentiation of neuronal cell progenitors depends on complex interactions between intrinsic cellular programs and environmental cues. Such interactions have recently been explored using an immortalized sympathoadrenal progenitor cell line, MAH. These studies have revealed that depolarizing conditions, in combin...

journal_title：Neuron

authors： Ip NY,Boulton TG,Li Y,Verdi JM,Birren SJ,Anderson DJ,Yancopoulos GD

更新日期：1994-08-01 00:00:00

abstract：:Injection of inositol 1,4,5 trisphosphate (InsP3) into Limulus ventral photoreceptors elevates the concentration of intracellular calcium ions and as a consequence depolarizes the photoreceptor. This InsP3-induced elevation can be inhibited by a prior injection of calcium or InsP3 delivered 1 s earlier. Recovery from ...

journal_title：Neuron

authors： Payne R,Flores TM,Fein A

更新日期：1990-04-01 00:00:00

abstract：:Expression of rat TrkA in Xenopus spinal neurons confers responsiveness of these neurons to nerve growth factor (NGF) in assays of neuronal survival and growth cone chemotropism. Mutational analysis indicates that coactivation of phospholipase C-gamma (PLC-gamma) and phosphoinositide 3-kinase (PI3-kinase) by specific ...

journal_title：Neuron

authors： Ming G,Song H,Berninger B,Inagaki N,Tessier-Lavigne M,Poo M

更新日期：1999-05-01 00:00:00

abstract：:Forty years ago, von Békésy demonstrated that the spatial source of an odorant is determined by comparing input across nostrils, but it is unknown how this comparison is effected in the brain. To address this, we delivered odorants to the left or right of the nose, and contrasted olfactory left versus right localizati...

journal_title：Neuron

authors： Porter J,Anand T,Johnson B,Khan RM,Sobel N

更新日期：2005-08-18 00:00:00

abstract：:Astrocytes are complex bushy cells that serve important functions through close contacts between their processes and synapses. However, the spatial interactions and dynamics of astrocyte processes relative to synapses have proven problematic to study in adult living brain tissue. Here, we report a genetically targeted...

journal_title：Neuron

authors： Octeau JC,Chai H,Jiang R,Bonanno SL,Martin KC,Khakh BS

更新日期：2018-04-04 00:00:00

abstract：:Recent binding studies in the central nervous system and other tissues provide evidence that the mammalian bombesin-like peptides, gastrin-releasing peptide (GRP) and neuromedin-B (NMB), exert their numerous physiological effects through at least two different receptors. We describe the structure and expression of a c...

journal_title：Neuron

authors： Wada E,Way J,Shapira H,Kusano K,Lebacq-Verheyden AM,Coy D,Jensen R,Battery J

更新日期：1991-03-01 00:00:00

abstract：:We measured amygdala activity in human volunteers during rapid visual presentations of fearful, happy, and neutral faces using functional magnetic resonance imaging (fMRI). The first experiment involved a fixed order of conditions both within and across runs, while the second one used a fully counterbalanced order in ...

journal_title：Neuron

authors： Breiter HC,Etcoff NL,Whalen PJ,Kennedy WA,Rauch SL,Buckner RL,Strauss MM,Hyman SE,Rosen BR

更新日期：1996-11-01 00:00:00

abstract：:Development of neuronal circuits is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1, which mediates attraction through the DCC receptor. We discovered that the Robo3 receptor fundamentally changed its mechanism of acti...

journal_title：Neuron

authors： Zelina P,Blockus H,Zagar Y,Péres A,Friocourt F,Wu Z,Rama N,Fouquet C,Hohenester E,Tessier-Lavigne M,Schweitzer J,Roest Crollius H,Chédotal A

更新日期：2014-12-17 00:00:00

abstract：:The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in inform...

journal_title：Neuron

authors： Jackman SL,Regehr WG

更新日期：2017-05-03 00:00:00

abstract：:Mouse vision is based on the parallel output of more than 30 functional types of retinal ganglion cells (RGCs). Little is known about how representations of visual information change between retina and dorsolateral geniculate nucleus (dLGN) of the thalamus, the main relay between retina and cortex. Here, we functional...

journal_title：Neuron

authors： Román Rosón M,Bauer Y,Kotkat AH,Berens P,Euler T,Busse L

更新日期：2019-04-17 00:00:00

abstract：:Neuroscience is an exciting and vibrant field, but building an academic career is not always easy. What are critical success indicators? Which tools help talented young neuroscientists conquer the challenges? In this NeuroView, we discuss instruments and steps that can help people progress through the ranks. ...

journal_title：Neuron

authors： Joëls M,Hoogenraad CC,Poirazi P,Di Luca M

更新日期：2015-05-06 00:00:00

abstract：:Real-time activity measurements of genetically identified neuroendocrine vasopressin neurons show they can anticipate osmotic challenges. In this issue of Neuron, Mandelblat-Cerf et al. (2017) show that correlating these results with ongoing behavior and plasma osmolality points to the existence of brain networks that...

journal_title：Neuron

authors： Watts AG

更新日期：2017-01-04 00:00:00

abstract：:Dynamic rearrangements of axon terminal arbors may be critical for establishing appropriate connections in the developing nervous system. Here, the changes in complex retinal axon arbors in the tecta of live Xenopus larvae were followed during the formation of the topographic retinotectal projection. Three-dimensional...

journal_title：Neuron

authors： O'Rourke NA,Cline HT,Fraser SE

更新日期：1994-04-01 00:00:00

abstract：:Memories are about the past, but they serve the future. Memory research often emphasizes the former aspect: focusing on the functions that re-constitute (re-member) experience and elucidating the various types of memories and their interrelations, timescales, and neural bases. Here we highlight the prospective nature ...

journal_title：Neuron

authors： Nobre AC,Stokes MG

更新日期：2019-10-09 00:00:00

abstract：:In this issue, Doucette and colleagues demonstrate that information related to whether an odor is currently linked to reward can be observed uniquely in population activity in the olfactory bulb, changing our understanding both of what is coded by the first olfactory relay in the CNS and of how this coding is instanti...

journal_title：Neuron

authors： Katz DB,Maier JX

更新日期：2011-03-24 00:00:00

abstract：:Previous work has hinted that prospective and retrospective coding modes exist in hippocampus. Prospective coding is believed to reflect memory retrieval processes, whereas retrospective coding is thought to be important for memory encoding. Here, we show in rats that separate prospective and retrospective modes exist...

journal_title：Neuron

authors： Bieri KW,Bobbitt KN,Colgin LL

更新日期：2014-05-07 00:00:00

abstract：:Anteroposterior (AP) patterning in the vertebrate hindbrain is dependent upon the establishment of segmental domains of Hox expression. We investigated the mechanism that governs the early expression of Hoxb4 and found that transient signaling from the paraxial mesoderm induces expression in the hindbrain. Induction i...

journal_title：Neuron

authors： Gould A,Itasaki N,Krumlauf R

更新日期：1998-07-01 00:00:00

abstract：:The replay of previously stored memories during hippocampal sharp wave ripples (SWRs) is thought to support both memory retrieval and consolidation in distributed hippocampal-neocortical circuits. Replay events consist of precisely timed sequences of spikes from CA3 and CA1 neurons that are coordinated both within and...

journal_title：Neuron

authors： Carr MF,Karlsson MP,Frank LM

更新日期：2012-08-23 00:00:00

abstract：:In this issue of Neuron, Holz et al. (2019) show that the synaptic protein Homer1a switches mGluR5 signaling to increase AMPA receptor activity for the rapid antidepressant actions of sleep deprivation. ...

journal_title：Neuron

authors： Albert PR

更新日期：2019-10-23 00:00:00

abstract：:We perceive motion when presented with spatiotemporal changes in contrast (second-order cue). This requires linear signals to be rectified and then summed in temporal order to compute direction. Although both operations have been attributed to cortex, rectification might occur in retina, prior to the ganglion cell. He...

journal_title：Neuron

authors： Demb JB,Zaghloul K,Sterling P

更新日期：2001-11-20 00:00:00

abstract：:Olfactory receptor neurons (ORNs) are replaced and differentiate in adult animals, but differentiation in dissociated cell culture has not been demonstrated. To test whether contact with the CNS regulates maturation, neonatal rat olfactory cells were grown on a culture substrate or on CNS astrocytes. Mature ORNs, immu...

journal_title：Neuron

authors： Pixley SK

更新日期：1992-06-01 00:00:00

abstract：:Long-term, but not short-term, facilitation induced by 5-HT in Aplysia sensory neurons is blocked by application of inhibitors of protein synthesis or RNA synthesis during the 1.5 hr training period. These findings suggest that genes and proteins not needed for the short-term process are required for long-term facilit...

journal_title：Neuron

authors： Barzilai A,Kennedy TE,Sweatt JD,Kandel ER

更新日期：1989-06-01 00:00:00

abstract：:Innate defensive responses are essential for animal survival and are conserved across species. The ventral tegmental area (VTA) plays important roles in learned appetitive and aversive behaviors, but whether it plays a role in mediating or modulating innate defensive responses is currently unknown. We report that VTAG...

journal_title：Neuron

authors： Zhou Z,Liu X,Chen S,Zhang Z,Liu Y,Montardy Q,Tang Y,Wei P,Liu N,Li L,Song R,Lai J,He X,Chen C,Bi G,Feng G,Xu F,Wang L

更新日期：2019-08-07 00:00:00

abstract：:Somatic mutation of the MTOR gene is a genetic etiology of focal malformations of cortical development. In this issue of Neuron, Park et al. (2018) identify defective autophagy-dependent ciliogenesis/Wnt signaling as an underlying mechanism affecting neuronal migration and cortical lamination. ...

journal_title：Neuron

authors： Di Nardo A,Sahin M

更新日期：2018-07-11 00:00:00

abstract：:In response to changes in membrane potential, voltage-dependent ion channel proteins undergo conformational rearrangements that lead to channel opening. These rearrangements move a net charge, measured as "gating current", across the membrane. Here we characterize the effects of the pharmacological blocker 4-aminopyri...

journal_title：Neuron

authors： McCormack K,Joiner WJ,Heinemann SH

更新日期：1994-02-01 00:00:00

abstract：:In the long-range neuronal migration of adult mammals, young neurons travel from the subventricular zone to the olfactory bulb, a long journey (millimeters to centimeters, depending on the species). How can these neurons migrate through the dense meshwork of neuronal and glial processes of the adult brain parenchyma? ...

journal_title：Neuron

authors： Kaneko N,Marín O,Koike M,Hirota Y,Uchiyama Y,Wu JY,Lu Q,Tessier-Lavigne M,Alvarez-Buylla A,Okano H,Rubenstein JL,Sawamoto K

更新日期：2010-07-29 00:00:00

abstract：:We used fMRI to investigate how moment-to-moment neural activity contributes to success or failure on individual trials of a visual working memory (WM) task. We found that different nodes of a distributed cortical network were activated to a greater extent for correct compared to incorrect trials during stimulus encod...

journal_title：Neuron

authors： Pessoa L,Gutierrez E,Bandettini P,Ungerleider L

更新日期：2002-08-29 00:00:00