Abstract:
:In humans the hippocampus is required for episodic memory, which extends into the spatial and temporal domains. Work on the rodent hippocampus has shown that NMDA receptor (NMDAR) -mediated plasticity is essential for spatial memory. Here, we have examined whether hippocampal NMDARs are also needed for temporal memory. We applied trace fear conditioning to knockout mice lacking NMDARs only in hippocampal CA1 pyramidal cells. This paradigm requires temporal processing because the conditional and unconditional stimuli are separated by 30 s (trace). We found that knockout mice failed to memorize this association but were indistinguishable from normal animals when the trace was removed. Thus, NMDARs in CA1 are crucial for the formation of memories that associate events across time.
journal_name
Neuronjournal_title
Neuronauthors
Huerta PT,Sun LD,Wilson MA,Tonegawa Sdoi
10.1016/s0896-6273(00)80909-5subject
Has Abstractpub_date
2000-02-01 00:00:00pages
473-80issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80909-5journal_volume
25pub_type
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