Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons.

abstract：:We have devised a simple bioassay for the identification of molecules that inhibit growth cone motility. Chick dorsal root ganglion (DRG) growth cones extending on laminin collapse when exposed to a suspension of embryonic brain membranes. Detergent-solubilized membranes from which the detergent has been removed colla...

journal_title：Neuron

authors： Raper JA,Kapfhammer JP

更新日期：1990-01-01 00:00:00

abstract：:Neuromodulators are important regulators of synaptic transmission throughout the brain. At the presynaptic terminal, neuromodulation of calcium channels (CaVs) can affect transmission not only by changing neurotransmitter release probability, but also by shaping short-term plasticity (STP). Indeed, changes in STP are ...

journal_title：Neuron

authors： Burke KJ Jr,Keeshen CM,Bender KJ

更新日期：2018-09-05 00:00:00

abstract：:Both the sec6/8 complex and septin filaments have been implicated in directing vesicles and proteins to sites of active membrane addition in yeast. The rat brain sec6/8 complex coimmunoprecipitates with a filament composed of four mammalian septins, suggesting an interaction between these complexes. One of the septins...

journal_title：Neuron

authors： Hsu SC,Hazuka CD,Roth R,Foletti DL,Heuser J,Scheller RH

更新日期：1998-06-01 00:00:00

abstract：:Careful functional dissection of mouse neuromuscular junctions (NMJs) formed in the absence of NCAM reveal that in spite of relatively normal morphology and ultrastructure, the presynaptic terminals have profound alterations in the mechanisms of recycling of synaptic vesicles. These alterations, including the appearan...

journal_title：Neuron

authors： Ryan TA

更新日期：2001-12-06 00:00:00

abstract：:The molecular mechanisms involved in glial/neuronal fate decisions during embryonic development are largely unknown. Here we show that the segment-polarity gene engrailed, which encodes a homeodomain protein, controls these decisions within an insect CNS lineage. The grasshopper median neuroblast (MNB) generates both ...

journal_title：Neuron

authors： Condron BG,Patel NH,Zinn K

更新日期：1994-09-01 00:00:00

abstract：:During synaptic development, proteins aggregate at specialized pre- and postsynaptic structures. Mechanisms that mediate protein clustering at these sites remain unknown. To investigate this process, we analyzed synaptic targeting of a postsynaptic density protein, PSD-95, by expressing green fluorescent protein- (GFP...

journal_title：Neuron

authors： Craven SE,El-Husseini AE,Bredt DS

更新日期：1999-03-01 00:00:00

abstract：:Immortalized retinal neurons have been established in tissue culture from retinal tumors arising in transgenic mice. The mice carry the SV40 T-antigen under the control of 5' flanking sequences from the human phenylethanolamine N-methyltransferase (PNMT) gene in order to target oncogene expression to adrenergic cell t...

journal_title：Neuron

authors： Hammang JP,Baetge EE,Behringer RR,Brinster RL,Palmiter RD,Messing A

更新日期：1990-05-01 00:00:00

abstract：:The fields of neuroscience and artificial intelligence (AI) have a long and intertwined history. In more recent times, however, communication and collaboration between the two fields has become less commonplace. In this article, we argue that better understanding biological brains could play a vital role in building i...

journal_title：Neuron

authors： Hassabis D,Kumaran D,Summerfield C,Botvinick M

更新日期：2017-07-19 00:00:00

abstract：:Cellular Ca2+ buffers determine amplitude and diffusional spread of neuronal Ca2+ signals. Fixed Ca2+ buffers tend to retard the signal and to lower the apparent diffusion coefficient (D(app)) of Ca2+, whereas mobile buffers contribute to Ca2+ redistribution. To estimate the impact of the expression of specific Ca2+-b...

journal_title：Neuron

authors： Gabso M,Neher E,Spira ME

更新日期：1997-03-01 00:00:00

abstract：:The nanoscale topographical arrangement of voltage-gated calcium channels (VGCC) and synaptic vesicles (SVs) determines synaptic strength and plasticity, but whether distinct spatial distributions underpin diversity of synaptic function is unknown. We performed single bouton Ca2+ imaging, Ca2+ chelator competition, im...

journal_title：Neuron

authors： Rebola N,Reva M,Kirizs T,Szoboszlay M,Lőrincz A,Moneron G,Nusser Z,DiGregorio DA

更新日期：2019-11-20 00:00:00

abstract：:It is a commonly held view that numbers are represented in an abstract way in both parietal lobes. This view is based on failures to find differences between various notational representations. Here we show that by using relatively smaller voxels together with an adaptation paradigm and analyzing subjects on an indivi...

journal_title：Neuron

authors： Cohen Kadosh R,Cohen Kadosh K,Kaas A,Henik A,Goebel R

更新日期：2007-01-18 00:00:00

abstract：:Neuronal motor commands, whether generating real or neuroprosthetic movements, are shaped by ongoing sensory feedback from the displacement being produced. Here we asked if cortical stimulation could provide artificial feedback during operant conditioning of cortical neurons. Simultaneous two-photon imaging and real-t...

journal_title：Neuron

authors： Prsa M,Galiñanes GL,Huber D

更新日期：2017-02-22 00:00:00

abstract：:Coordination between sequential steps in synaptic vesicle endocytosis, including clathrin coat formation, fission, and uncoating, appears to involve proteinprotein interactions. Here, we show that compounds that disrupt interactions of the SH3 domain of endophilin with dynamin and synaptojanin impair synaptic vesicle ...

journal_title：Neuron

authors： Gad H,Ringstad N,Löw P,Kjaerulff O,Gustafsson J,Wenk M,Di Paolo G,Nemoto Y,Crun J,Ellisman MH,De Camilli P,Shupliakov O,Brodin L

更新日期：2000-08-01 00:00:00

abstract：:Motion detection is a fundamental neural computation performed by many sensory systems. In the fly, local motion computation is thought to occur within the first two layers of the visual system, the lamina and medulla. We constructed specific genetic driver lines for each of the 12 neuron classes in the lamina. We the...

journal_title：Neuron

authors： Tuthill JC,Nern A,Holtz SL,Rubin GM,Reiser MB

更新日期：2013-07-10 00:00:00

abstract：:Firing patterns of neurons in the orbitofrontal cortex (OF) were analyzed in rats trained to perform a task that encouraged incidental associations between distinct odors and the places where their occurrence was detected. Many of the neurons fired differentially when the animals were at a particular location or sampl...

journal_title：Neuron

authors： Lipton PA,Alvarez P,Eichenbaum H

更新日期：1999-02-01 00:00:00

abstract：:Rodents begin to use bilaterally coordinated, rhythmic sweeping of their vibrissae ("whisking") for environmental exploration around 2 weeks after birth. Whether (and how) the vibrissal control circuitry changes after birth is unknown, and the relevant premotor circuitry remains poorly characterized. Using a modified ...

journal_title：Neuron

authors： Takatoh J,Nelson A,Zhou X,Bolton MM,Ehlers MD,Arenkiel BR,Mooney R,Wang F

更新日期：2013-01-23 00:00:00

abstract：:Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging g...

journal_title：Neuron

authors： Milham MP,Ai L,Koo B,Xu T,Amiez C,Balezeau F,Baxter MG,Blezer ELA,Brochier T,Chen A,Croxson PL,Damatac CG,Dehaene S,Everling S,Fair DA,Fleysher L,Freiwald W,Froudist-Walsh S,Griffiths TD,Guedj C,Hadj-Bouziane F,

更新日期：2018-10-10 00:00:00

abstract：:In this issue of Neuron, Stepanyants et al. embark on quantitative analyses of the axonal and dendritic arbors of cortical neurons. They test whether the paths taken by axons actually bring them closer to their true synaptic partners than they would have gotten by chance encounters based on the same axon trajectories....

journal_title：Neuron

authors： Callaway EM

更新日期：2004-07-22 00:00:00

abstract：:In this perspective I tell the story (albeit a clearly abridged version) of how our knowledge of ion conduction through ion channels has evolved from a purely electrical concept to a structural dynamics view of ions interacting with a membrane protein. Our progress in this field has shown steady growth over the years ...

journal_title：Neuron

authors： Bezanilla F

更新日期：2008-11-06 00:00:00

abstract：:Synaptic clustering of neurotransmitter receptors is crucial for efficient signal transduction and integration in neurons. PDZ domain-containing proteins such as PSD-95/SAP90 interact with the intracellular C termini of a variety of receptors and are thought to be important in the targeting and anchoring of receptors ...

journal_title：Neuron

authors： Xia J,Zhang X,Staudinger J,Huganir RL

更新日期：1999-01-01 00:00:00

abstract：:Presynaptic neurexins (Nrxs) and type IIa receptor-type protein tyrosine phosphatases (RPTPs) organize synapses through a network of postsynaptic ligands. We show that leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) differentially engage the protein domains of Nrx but require its heparan sulfate (HS) modi...

journal_title：Neuron

authors： Roppongi RT,Dhume SH,Padmanabhan N,Silwal P,Zahra N,Karimi B,Bomkamp C,Patil CS,Champagne-Jorgensen K,Twilley RE,Zhang P,Jackson MF,Siddiqui TJ

更新日期：2020-04-08 00:00:00

abstract：:Two cDNAs encoding novel GABAA receptor subunits were isolated from a rat brain library. These subunits, gamma 2 and delta, share approximately 35% sequence identity with alpha and beta subunits and form functional GABA-gated chloride channels when expressed alone in vitro. The gamma 2 subunit is the rat homolog of th...

journal_title：Neuron

authors： Shivers BD,Killisch I,Sprengel R,Sontheimer H,Köhler M,Schofield PR,Seeburg PH

更新日期：1989-09-01 00:00:00

abstract：:The brain has often been described, quite accurately, as one of the most complex objects in the natural world. Understanding its workings, to say nothing about intervening in them, is among the hardest problems in science. While this makes the challenge all the more enticing, in the short term, it acts to limit the im...

journal_title：Neuron

authors： Sinha P

更新日期：2016-11-02 00:00:00

abstract：:Primates with long-standing therapeutic amputations of a limb at a young age were used to investigate the possibility that deefferented motor nerves sprout to new muscle targets. Injections of anatomical tracers into the muscles proximal to the amputated stump labeled a larger extent of motoneurons than matched inject...

journal_title：Neuron

authors： Wu CW,Kaas JH

更新日期：2000-12-01 00:00:00

abstract：:Direction selectivity (DS) is an important neuronal property in the visual system, but how DS is generated beyond the retina remains controversial. Here, we report a close correspondence between the preferred direction (PD) and the morphology of DS cells in the optic tectum. Ca(2+) imaging in cells expressing the gene...

journal_title：Neuron

authors： Gabriel JP,Trivedi CA,Maurer CM,Ryu S,Bollmann JH

更新日期：2012-12-20 00:00:00

abstract：:During development of the mammalian nervous system, neural stem cells generate neurons first and glia second, thereby allowing the initial establishment of neural circuitry, and subsequent matching of glial numbers and position to that circuitry. Here, we have reviewed work addressing the mechanisms underlying this ti...

journal_title：Neuron

authors： Miller FD,Gauthier AS

更新日期：2007-05-03 00:00:00

abstract：:The combination of brain imaging and genetics promises to identify neural mechanisms underlying complex traits such as cognition and psychiatric disorder. The study by Heck et al. (2014) in this issue of Neuron highlights voltage-gated cation channel activity as a likely link and culprit. ...

journal_title：Neuron

authors： McIntosh A,Deary I,Porteous DJ

更新日期：2014-03-05 00:00:00

abstract：:T-type calcium channels are essential contributors to the transmission of nociceptive signals in the primary afferent pain pathway. Here, we show that T-type calcium channels are ubiquitinated by WWP1, a plasma-membrane-associated ubiquitin ligase that binds to the intracellular domain III-IV linker region of the Cav3...

journal_title：Neuron

authors： García-Caballero A,Gadotti VM,Stemkowski P,Weiss N,Souza IA,Hodgkinson V,Bladen C,Chen L,Hamid J,Pizzoccaro A,Deage M,François A,Bourinet E,Zamponi GW

更新日期：2014-09-03 00:00:00

abstract：:Flies exhibit a repertoire of aerial acrobatics unmatched in robustness and aerodynamic sophistication. The exquisite control of this complex behavior emerges from encoding intricate patterns of optic flow, and the translation of these visual signals into the mechanical language of the motor system. Recent advances in...

journal_title：Neuron

authors： Frye MA,Dickinson MH

更新日期：2001-11-08 00:00:00

abstract：:The function of the CB2 cannabinoid receptor in the brain has long been a matter of debate. In this issue of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a cell-intrinsic hyperpolarization that controls self activity. ...

journal_title：Neuron

authors： Quraishi SA,Paladini CA

更新日期：2016-05-18 00:00:00