The cadherin Flamingo mediates level-dependent interactions that guide photoreceptor target choice in Drosophila.

Abstract:

:Quantitative differences in cadherin activity have been proposed to play important roles in patterning connections between pre- and postsynaptic neurons. However, no examples of such a function have yet been described, and the mechanisms that would allow such differences to direct growth cones to specific synaptic targets are unknown. In the Drosophila visual system, photoreceptors are genetically programmed to make a complex, stereotypic set of synaptic connections. Here we show that the atypical cadherin Flamingo functions as a short-range, homophilic signal, passing between specific R cell growth cones to influence their choice of postsynaptic partners. We find that individual growth cones are sensitive to differences in Flamingo activity through opposing interactions between neighboring cells and require these interactions to be balanced in order to extend along the appropriate trajectory.

journal_name

Neuron

journal_title

Neuron

authors

Chen PL,Clandinin TR

doi

10.1016/j.neuron.2008.01.007

subject

Has Abstract

pub_date

2008-04-10 00:00:00

pages

26-33

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(08)00038-X

journal_volume

58

pub_type

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