The cadherin Flamingo mediates level-dependent interactions that guide photoreceptor target choice in Drosophila.


:Quantitative differences in cadherin activity have been proposed to play important roles in patterning connections between pre- and postsynaptic neurons. However, no examples of such a function have yet been described, and the mechanisms that would allow such differences to direct growth cones to specific synaptic targets are unknown. In the Drosophila visual system, photoreceptors are genetically programmed to make a complex, stereotypic set of synaptic connections. Here we show that the atypical cadherin Flamingo functions as a short-range, homophilic signal, passing between specific R cell growth cones to influence their choice of postsynaptic partners. We find that individual growth cones are sensitive to differences in Flamingo activity through opposing interactions between neighboring cells and require these interactions to be balanced in order to extend along the appropriate trajectory.






Chen PL,Clandinin TR




Has Abstract


2008-04-10 00:00:00
















  • The neural basis of perceptual learning.

    abstract::Perceptual learning is a lifelong process. We begin by encoding information about the basic structure of the natural world and continue to assimilate information about specific patterns with which we become familiar. The specificity of the learning suggests that all areas of the cerebral cortex are plastic and can rep...


    pub_type: 杂志文章,评审


    authors: Gilbert CD,Sigman M,Crist RE

    更新日期:2001-09-13 00:00:00

  • Interactions between entorhinal axons and target hippocampal neurons: a role for glutamate in the development of hippocampal circuitry.

    abstract::A coculture system consisting of input axons from entorhinal cortex explants and target hippocampal pyramidal neurons was used to demonstrate that glutamate, released spontaneously from afferent axons, can influence both dendritic geometry of target neurons and formation of presumptive synaptic sites. Dendritic outgro...


    pub_type: 杂志文章


    authors: Mattson MP,Lee RE,Adams ME,Guthrie PB,Kater SB

    更新日期:1988-11-01 00:00:00

  • Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors.

    abstract::NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor-expressing cells, and the majority of native receptors are triheteromers containing two GluN1 and two different GluN2. In contrast to diheterome...


    pub_type: 杂志文章


    authors: Hansen KB,Ogden KK,Yuan H,Traynelis SF

    更新日期:2014-03-05 00:00:00

  • Pten-less dentate granule cells make fits.

    abstract::Hippocampal dentate granule cell abnormalities are thought to play a causative role in temporal lobe epilepsy, but their precise contribution has not been dissociated from coexisting pathological changes. In this issue of Neuron, Pun et al. (2012) show, for the first time, that inducing proexcitatory changes in a subs...


    pub_type: 评论,杂志文章


    authors: Althaus AL,Parent JM

    更新日期:2012-09-20 00:00:00

  • GABA excitation in the adult brain: a mechanism for excitation- neurogenesis coupling.

    abstract::The production of new neurons in the adult hippocampus is exquisitely regulated, and alterations in this process may underlie both normal and pathological hippocampal function. In this issue of Neuron, Tozuka et al. describe electrophysiological recordings that target proliferating progenitor cells in adult mouse hipp...


    pub_type: 评论,杂志文章


    authors: Deisseroth K,Malenka RC

    更新日期:2005-09-15 00:00:00

  • Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models.

    abstract::The motor symptoms of Parkinson's disease (PD) are thought to stem from an imbalance in the activity of striatal direct- and indirect-pathway spiny projection neurons (SPNs). Disease-induced alterations in the activity of networks controlling SPNs could contribute to this imbalance. One of these networks is anchored b...


    pub_type: 杂志文章


    authors: Tanimura A,Du Y,Kondapalli J,Wokosin DL,Surmeier DJ

    更新日期:2019-02-06 00:00:00

  • Sensing without touching: psychophysical performance based on cortical microstimulation.

    abstract::Unequivocal proof that the activity of a localized cortical neuronal population provides sufficient basis for a specific cognitive function has rarely been obtained. We looked for such proof in monkeys trained to discriminate between two mechanical flutter stimuli applied sequentially to the fingertips. Microelectrode...


    pub_type: 杂志文章


    authors: Romo R,Hernández A,Zainos A,Brody CD,Lemus L

    更新日期:2000-04-01 00:00:00

  • Distinct tau prion strains propagate in cells and mice and define different tauopathies.

    abstract::Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique conformations ("strains") in vivo that link structure to patterns of pathology. We now find that tau meets this criterion. Stably expressed tau repeat domain indefin...


    pub_type: 杂志文章


    authors: Sanders DW,Kaufman SK,DeVos SL,Sharma AM,Mirbaha H,Li A,Barker SJ,Foley AC,Thorpe JR,Serpell LC,Miller TM,Grinberg LT,Seeley WW,Diamond MI

    更新日期:2014-06-18 00:00:00

  • The functional organization of the barrel cortex.

    abstract::The tactile somatosensory pathway from whisker to cortex in rodents provides a well-defined system for exploring the link between molecular mechanisms, synaptic circuits, and behavior. The primary somatosensory cortex has an exquisite somatotopic map where each individual whisker is represented in a discrete anatomica...


    pub_type: 杂志文章,评审


    authors: Petersen CC

    更新日期:2007-10-25 00:00:00

  • Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior rhythm.

    abstract::The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a network structure composed of multiple types of neurons. Here, we report that mice with a Bmal1 deletion specific to arginine vasopressin (AVP)-producing neurons showed marked lengthening in the free-running period and activity time of...


    pub_type: 杂志文章


    authors: Mieda M,Ono D,Hasegawa E,Okamoto H,Honma K,Honma S,Sakurai T

    更新日期:2015-03-04 00:00:00

  • Morphogenetic and cellular movements that shape the mouse cerebellum; insights from genetic fate mapping.

    abstract::We used the cerebellum as a model to study the morphogenetic and cellular processes underlying the formation of elaborate brain structures from a simple neural tube, using an inducible genetic fate mapping approach in mouse. We demonstrate how a 90 degrees rotation between embryonic days 9 and 12 converts the rostral-...


    pub_type: 杂志文章


    authors: Sgaier SK,Millet S,Villanueva MP,Berenshteyn F,Song C,Joyner AL

    更新日期:2005-01-06 00:00:00

  • Immunocytochemical localization of the precursor protein for beta-amyloid in the rat central nervous system.

    abstract::Two rabbit polyclonal antibodies generated against different portions of the amyloid precursor protein were used to localize this protein in normal rat brain. Light and electron microscopic immunohistochemical localizations demonstrate that the protein is widely distributed throughout the neuraxis, with the highest co...


    pub_type: 杂志文章


    authors: Card JP,Meade RP,Davis LG

    更新日期:1988-11-01 00:00:00

  • Control over conflict during movement preparation: role of posterior parietal cortex.

    abstract::Flexible behavior in humans often requires that rapid choices be made between conflicting action plans. Although much attention has focused on prefrontal regions, little is understood about the contribution of parietal cortex under situations of response conflict. Here we show that right parietal damage associated wit...


    pub_type: 杂志文章


    authors: Coulthard EJ,Nachev P,Husain M

    更新日期:2008-04-10 00:00:00

  • Dopaminergic modulation of axon initial segment calcium channels regulates action potential initiation.

    abstract::Action potentials initiate in the axon initial segment (AIS), a specialized compartment enriched with Na(+) and K(+) channels. Recently, we found that T- and R-type Ca(2+) channels are concentrated in the AIS, where they contribute to local subthreshold membrane depolarization and thereby influence action potential in...


    pub_type: 杂志文章


    authors: Bender KJ,Ford CP,Trussell LO

    更新日期:2010-11-04 00:00:00

  • Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission.

    abstract::It has recently been found that caspases not only function in apoptosis, but are also crucial for nonapoptotic processes such as NMDA receptor-dependent long-term depression (LTD) of synaptic transmission. It remains unknown, however, how caspases are activated and how neurons escape death in LTD. Here we show that ca...


    pub_type: 杂志文章


    authors: Jiao S,Li Z

    更新日期:2011-05-26 00:00:00

  • Primate Neurons Flex Their Musclin.

    abstract::Sensory experience evokes long-lasting changes in neural circuits through activity-dependent gene expression. Ataman et al. (2016) report in Nature that primates evolved novel transcriptional responses to neuronal activity, including induction of musclin/osteocrin (OSTN), which may regulate specialized aspects of prim...


    pub_type: 杂志文章


    authors: Pollen AA,Kriegstein AR

    更新日期:2016-11-23 00:00:00

  • Fas(t) balls and Lou Gehrig disease. A clue to selective vulnerability of motor neurons?

    abstract::The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked m...


    pub_type: 评论,杂志文章,评审


    authors: Xiong ZQ,McNamara JO

    更新日期:2002-09-12 00:00:00

  • High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.

    abstract::AMPA-type glutamate receptors (AMPARs) are responsible for a variety of processes in the mammalian brain including fast excitatory neurotransmission, postsynaptic plasticity, or synapse development. Here, with comprehensive and quantitative proteomic analyses, we demonstrate that native AMPARs are macromolecular compl...


    pub_type: 杂志文章


    authors: Schwenk J,Harmel N,Brechet A,Zolles G,Berkefeld H,Müller CS,Bildl W,Baehrens D,Hüber B,Kulik A,Klöcker N,Schulte U,Fakler B

    更新日期:2012-05-24 00:00:00

  • Hierarchical Encoding of Attended Auditory Objects in Multi-talker Speech Perception.

    abstract::Humans can easily focus on one speaker in a multi-talker acoustic environment, but how different areas of the human auditory cortex (AC) represent the acoustic components of mixed speech is unknown. We obtained invasive recordings from the primary and nonprimary AC in neurosurgical patients as they listened to multi-t...


    pub_type: 杂志文章


    authors: O'Sullivan J,Herrero J,Smith E,Schevon C,McKhann GM,Sheth SA,Mehta AD,Mesgarani N

    更新日期:2019-12-18 00:00:00

  • Individual Variation in Functional Topography of Association Networks in Youth.

    abstract::The spatial distribution of large-scale functional networks on the cerebral cortex differs between individuals and is particularly variable in association networks that are responsible for higher-order cognition. However, it remains unknown how this functional topography evolves in development and supports cognition. ...


    pub_type: 杂志文章


    authors: Cui Z,Li H,Xia CH,Larsen B,Adebimpe A,Baum GL,Cieslak M,Gur RE,Gur RC,Moore TM,Oathes DJ,Alexander-Bloch AF,Raznahan A,Roalf DR,Shinohara RT,Wolf DH,Davatzikos C,Bassett DS,Fair DA,Fan Y,Satterthwaite TD

    更新日期:2020-04-22 00:00:00

  • A Corticostriatal Balancing Act Supports Skill Learning.

    abstract::In this issue of Neuron, Kupferschmidt et al. (2017) reveal the shifting dynamics of functionally defined corticostriatal pathways during skill learning in mice using fiber photometry. They show different time courses in plasticity of associative and sensorimotor circuits across learning that involve changes at both t...


    pub_type: 杂志文章


    authors: Corbit VL,Ahmari SE,Gittis AH

    更新日期:2017-10-11 00:00:00

  • Heteromeric AMPA receptors assemble with a preferred subunit stoichiometry and spatial arrangement.

    abstract::AMPA receptors are thought to be a tetrameric assembly of the subunits GluR1-4. We have examined whether two coexpressed subunits (GluR1/2) combine at random to form channels, or preferentially assemble with a specific stoichiometry and spatial configuration. The subunits carried markers controlling ion permeation and...


    pub_type: 杂志文章


    authors: Mansour M,Nagarajan N,Nehring RB,Clements JD,Rosenmund C

    更新日期:2001-12-06 00:00:00

  • EphB2 guides axons at the midline and is necessary for normal vestibular function.

    abstract::Mice lacking the EphB2 receptor tyrosine kinase display a cell-autonomous, strain-specific circling behavior that is associated with vestibular phenotypes. In mutant embryos, the contralateral inner ear efferent growth cones exhibit inappropriate pathway selection at the midline, while in mutant adults, the endolymph-...


    pub_type: 杂志文章


    authors: Cowan CA,Yokoyama N,Bianchi LM,Henkemeyer M,Fritzsch B

    更新日期:2000-05-01 00:00:00

  • All asleep-but inhibition is wide awake.

    abstract::Depending on the arousal state, neuronal networks display discrete activity patterns that profoundly affect information processing in the brain. In this issue of Neuron, Kurotani et al. report bidirectional modification of inhibition by oscillatory patterns in the neocortex; a mechanism likely to control the impact of...


    pub_type: 评论,杂志文章


    authors: Letzkus JJ,Stuart GJ

    更新日期:2008-03-27 00:00:00

  • Probing the intracellular calcium sensitivity of transmitter release during synaptic facilitation.

    abstract::In nerve terminals, residual Ca(2+) remaining from previous activity can cause facilitation of transmitter release by a mechanism that is still under debate. Here we show that the intracellular Ca(2+) sensitivity of transmitter release at the calyx of Held is largely unchanged during facilitation, which leaves an incr...


    pub_type: 杂志文章


    authors: Felmy F,Neher E,Schneggenburger R

    更新日期:2003-03-06 00:00:00

  • Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions.

    abstract::RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of...


    pub_type: 杂志文章,评审


    authors: Nussbacher JK,Tabet R,Yeo GW,Lagier-Tourenne C

    更新日期:2019-04-17 00:00:00

  • The mysterious motivational functions of mesolimbic dopamine.

    abstract::Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional to label dopamine neurons as "reward" neurons, this...


    pub_type: 杂志文章,评审


    authors: Salamone JD,Correa M

    更新日期:2012-11-08 00:00:00

  • Toward a neural basis for social behavior.

    abstract::Nearly 25 years ago, the shared interests of psychologists and biologists in understanding the neural basis of social behavior led to the inception of social neuroscience. In the past decade, this field has exploded, in large part due to the infusion of studies that use fMRI. At the same time, tensions have arisen abo...


    pub_type: 历史文章,杂志文章,评审


    authors: Stanley DA,Adolphs R

    更新日期:2013-10-30 00:00:00

  • Synaptic augmentation by 5-HT at rested Aplysia sensorimotor synapses: independence of action potential prolongation.

    abstract::Short-term augmentation of synaptic transmission at sensory neuron synapses of Aplysia contributes to behavioral sensitization and is one of the current models for a cellular mechanism of learning. This neuromodulatory process, mediated at least in part by the facilitatory neurotransmitter serotonin (5-HT) acting thro...


    pub_type: 杂志文章


    authors: Klein M

    更新日期:1994-07-01 00:00:00

  • An automatic valuation system in the human brain: evidence from functional neuroimaging.

    abstract::According to economic theories, preference for one item over others reveals its rank value on a common scale. Previous studies identified brain regions encoding such values. Here we verify that these regions can valuate various categories of objects and further test whether they still express preferences when attentio...


    pub_type: 杂志文章


    authors: Lebreton M,Jorge S,Michel V,Thirion B,Pessiglione M

    更新日期:2009-11-12 00:00:00