Abstract:
:Quantitative differences in cadherin activity have been proposed to play important roles in patterning connections between pre- and postsynaptic neurons. However, no examples of such a function have yet been described, and the mechanisms that would allow such differences to direct growth cones to specific synaptic targets are unknown. In the Drosophila visual system, photoreceptors are genetically programmed to make a complex, stereotypic set of synaptic connections. Here we show that the atypical cadherin Flamingo functions as a short-range, homophilic signal, passing between specific R cell growth cones to influence their choice of postsynaptic partners. We find that individual growth cones are sensitive to differences in Flamingo activity through opposing interactions between neighboring cells and require these interactions to be balanced in order to extend along the appropriate trajectory.
journal_name
Neuronjournal_title
Neuronauthors
Chen PL,Clandinin TRdoi
10.1016/j.neuron.2008.01.007subject
Has Abstractpub_date
2008-04-10 00:00:00pages
26-33issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(08)00038-Xjournal_volume
58pub_type
杂志文章相关文献
NEURON文献大全abstract::At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic nerve to the brain. Available strategies of promoting axon regeneration act on only some of these types. Here we tested the hypothesis that overexpressing developmentally important transcription factors in adult RGCs could repr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.05.035
更新日期:2017-06-21 00:00:00
abstract::We recently applied multiplexed seqFISH to profile expressions of hundreds of genes at the single-cell level in situ (Shah et al., 2016) and provided a map of spatial heterogeneity within each subregion, reconciling previously contradictory descriptions of CA1 at lower spatial resolutions. The accompanying Matters Ari...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.05.008
更新日期:2017-05-17 00:00:00
abstract::Using somatic cell nuclear transfer, Hazen et al. (2016) examined clonally expanded single neurons for mutations and found ∼100 mutations from a variety of classes. Post-mitotic mutations in individual neurons represent an exploratory direction for finding fundamental origins of neurodegeneration. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2016.02.042
更新日期:2016-03-16 00:00:00
abstract::Primates with long-standing therapeutic amputations of a limb at a young age were used to investigate the possibility that deefferented motor nerves sprout to new muscle targets. Injections of anatomical tracers into the muscles proximal to the amputated stump labeled a larger extent of motoneurons than matched inject...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00167-7
更新日期:2000-12-01 00:00:00
abstract::Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8) possess pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified InsP6 kinases designated InsP6K1 and InsP6K2. We now report the identification, cloning, and characterization of a n...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00384-1
更新日期:2001-08-16 00:00:00
abstract::The MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin prep...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90015-2
更新日期:1995-12-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) is expressed at high levels in hippocampal neurons, and its expression is modulated by neural activity. Knockout mice can be used to study the roles of molecules like BDNF in synaptic plasticity with more molecular specificity than is possible using pharmacological approaches. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80140-3
更新日期:1996-06-01 00:00:00
abstract::There has been a surge of interest in how inhibitory neurons influence the output of local circuits in the brain. In this issue of Neuron, Scholl et al. (2015) provide a compelling argument for what one class of inhibitory neurons actually does. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2015.06.041
更新日期:2015-07-15 00:00:00
abstract::The enteric nervous system (ENS) in vertebrates is derived mainly from vagal neural crest cells that enter the foregut and colonize the entire wall of the gastrointestinal tract. Failure to completely colonize the gut results in the absence of enteric ganglia (Hirschsprung's disease). Two signaling systems mediated by...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00730-x
更新日期:2003-12-04 00:00:00
abstract::The vertebrate ventral midbrain contains 3-4 x 10(4) dopaminergic neurons that influence motor activity, emotional behavior, and cognition. Recently, glial cell line-derived neurotrophic factor (GDNF) was shown to be a potent survival factor for these dopaminergic neurons in culture. However, many midbrain dopaminergi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90062-0
更新日期:1994-11-01 00:00:00
abstract::Accurate perception of the actions and intentions of other people is essential for successful interactions in a social environment. Several cortical areas that support this process respond selectively in fMRI to static and dynamic displays of human bodies and faces. Here we apply pattern-analysis techniques to arrive ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.02.004
更新日期:2006-03-16 00:00:00
abstract::Since the early days of research into language and the brain, word meaning was assumed to be processed in specific brain regions, which most modern neuroscientists localize to the left temporal lobe. Here we use event-related fMRI to show that action words referring to face, arm, or leg actions (e.g., to lick, pick, o...
journal_title:Neuron
pub_type: 临床试验,杂志文章
doi:10.1016/s0896-6273(03)00838-9
更新日期:2004-01-22 00:00:00
abstract::Neuronal activity-dependent processes are believed to mediate the formation of synaptic connections during neocortical development, but the underlying intracellular mechanisms are not known. In the visual system, altering the pattern of visually driven neuronal activity by monocular deprivation induces cortical synapt...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80679-0
更新日期:1999-01-01 00:00:00
abstract::Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilateral...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.08.015
更新日期:2013-11-20 00:00:00
abstract::LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using genetic and biochemical studies involving Lrrk loss-of-function mutants and Parkinson-related LRRK2(G2019S) gain-of-kinase function, we sh...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.08.022
更新日期:2012-09-20 00:00:00
abstract::As a means to automate the three-dimensional histological analysis of brain tissue, we demonstrate the use of femtosecond laser pulses to iteratively cut and image fixed as well as fresh tissue. Cuts are accomplished with 1 to 10 microJ pulses to ablate tissue with micron precision. We show that the permeability, immu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00370-2
更新日期:2003-07-03 00:00:00
abstract::Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establis...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.05.006
更新日期:2014-07-02 00:00:00
abstract::Memory and synaptic plasticity exhibit distinct temporal phases, with long-lasting forms distinguished by their dependence on macromolecular synthesis. Prevailing models for the molecular mechanisms underlying long-lasting synaptic plasticity have largely focused on transcriptional regulation. However, a growing body ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2004.09.013
更新日期:2004-09-30 00:00:00
abstract::Amphetamine (AMPH) releases monoamines, transiently stimulates locomotion, and inhibits feeding. Using a genetic approach, we show that mice lacking dopamine (DA-deficient, or DD, mice) are resistant to the hypophagic effects of a moderate dose of AMPH (2 microg/g) but manifest normal AMPH-induced hypophagia after res...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.10.009
更新日期:2004-10-28 00:00:00
abstract::What underlies the large variation in mEPSC amplitude in the auditory system? And is this variability important? In this issue of Neuron, Li et al. (2014) address the significance of large mEPSCs to auditory processing and Chapochnikov et al. (2014) describe a novel mechanism underlying them. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.09.013
更新日期:2014-09-17 00:00:00
abstract::Cortical GABAergic interneurons have essential roles for information processing and their dysfunction is implicated in neuropsychiatric disorders. Transcriptional codes are elucidating mechanisms of interneuron specification in the MGE (a subcortical progenitor zone), which regulate their migration, integration, and f...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.02.030
更新日期:2014-04-16 00:00:00
abstract::Huntington's disease-like-2 (HDL2) is a phenocopy of Huntington's disease caused by CTG/CAG repeat expansion at the Junctophilin-3 (JPH3) locus. The mechanisms underlying HDL2 pathogenesis remain unclear. Here we developed a BAC transgenic mouse model of HDL2 (BAC-HDL2) that exhibits progressive motor deficits, select...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.03.021
更新日期:2011-05-12 00:00:00
abstract::As different classes of sensory neurons project into the CNS, their axons segregate and establish distinct trajectories and target zones. One striking instance of axonal segregation is the projection of sensory neurons into the spinal cord, where proprioceptive axons avoid the superficial dorsal horn-the target zone o...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.10.032
更新日期:2006-12-07 00:00:00
abstract::Capsaicin, the main pungent ingredient in "hot" chili peppers, elicits buming pain by activating specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid receptor (VR1) is a cation channel that is also activated by noxious heat. Here, analysis of heat-evoked single channel currents in excised memb...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80564-4
更新日期:1998-09-01 00:00:00
abstract::Migraine is a common, disabling, multifactorial, episodic neurovascular disorder of unknown etiology. Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine with aura that is caused by missense mutations in the CACNA1A gene that encodes the alpha(1) subunit of neuronal Ca(v)2.1 Ca(2+) channels....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00085-6
更新日期:2004-03-04 00:00:00
abstract::We have devised a simple bioassay for the identification of molecules that inhibit growth cone motility. Chick dorsal root ganglion (DRG) growth cones extending on laminin collapse when exposed to a suspension of embryonic brain membranes. Detergent-solubilized membranes from which the detergent has been removed colla...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90440-q
更新日期:1990-01-01 00:00:00
abstract::In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP)...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00465-3
更新日期:2003-08-28 00:00:00
abstract::The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of b...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00368-4
更新日期:2003-07-03 00:00:00
abstract::The study of patients with brain lesions has made major historical contributions to cognitive neuroscience. Here I argue for an increased investment in modern lesion mapping, complementing fMRI studies and laying the conceptual and analytic foundations for future techniques that could experimentally manipulate human b...
journal_title:Neuron
pub_type: 历史文章,杂志文章
doi:10.1016/j.neuron.2016.05.014
更新日期:2016-06-15 00:00:00
abstract::During the metamorphosis of the Xenopus laevis retina, thyroid hormone (TH) preferentially induces ventral ciliary marginal zone (CMZ) cells to both increase their proliferation and give rise to ipsilaterally projecting ganglion cells. Here we show that dorsal CMZ cells express type III deiodinase (D3), an enzyme that...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81034-x
更新日期:1999-12-01 00:00:00