Abstract：
:We investigated the contribution of the inferior temporal (IT) cortical neurons to the active maintenance of internal representations. The activity of single neurons in the IT cortex was recorded while the monkeys performed a sequential-type associative memory task in which distractor stimuli interrupted the delay epoch between the cue and target (paired-associate) stimuli. For each neuron, information about each stimulus conveyed by the delay activity was estimated as a coefficient of multiple regression analysis. We found that target information derived from long-term memory (LTM) persisted despite the distractors. By contrast, cue information derived from the visual system was attenuated and frequently replaced by distractor information. These results suggest that LTM-derived information required for upcoming behavior is actively maintained in the IT neurons, whereas visually derived information tends to be updated irrespective of behavioral relevance.
journal_name
Neuronjournal_title
Neuronauthors
Takeda M,Naya Y,Fujimichi R,Takeuchi D,Miyashita Ydoi
10.1016/j.neuron.2005.09.028subject
Has Abstractpub_date
2005-12-08 00:00:00pages
839-48issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(05)00888-3journal_volume
48pub_type
杂志文章相关文献
NEURON文献大全abstract：:Using a transgenic mouse line in which GFP is expressed in a single population of retinal ganglion cells (RGCs), Huberman and colleagues report in this issue of Neuron that the axon terminals of RGCs exhibit an orderly pattern of distribution in the higher visual centers. This pattern undergoes a developmental refinem...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2008.08.001
更新日期：2008-08-14 00:00:00
abstract：:Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation and mechanotransduction have remained functionally undefined. Here we report our find...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.01.046
更新日期：2016-03-16 00:00:00
abstract：:Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in excitatory circuits. Memory formation in the brain is associated with synaptic remodeling, but how this affects PAPs and therefore extra...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.08.030
更新日期：2020-12-09 00:00:00
abstract：:Synaptotagmin 7 (Syt7) was originally identified as a slow Ca2+ sensor for lysosome fusion, but its function at fast synapses is controversial. The paper by Luo and Südhof (2017) in this issue of Neuron shows that at the calyx of Held in the auditory brainstem Syt7 triggers asynchronous release during stimulus trains,...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.05.011
更新日期：2017-05-17 00:00:00
abstract：:Outer hair cells (OHCs) provide amplification in the mammalian cochlea using somatic force generation underpinned by voltage-dependent conformational changes of the motor protein prestin. However, prestin must be gated by changes in membrane potential on a cycle-by-cycle basis and the periodic component of the recepto...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.04.024
更新日期：2011-06-23 00:00:00
abstract：:Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)00008-8
更新日期：2000-07-01 00:00:00
abstract：:Neurons adapt their synaptic responses to the activity of the underlying network. In this issue of Neuron, Thiagarajan and colleagues report on specific subcellular mechanisms of homeostasis after prolonged neuronal inactivity. The results have important implications not only for neuronal homeostasis but also for furt...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2005.08.018
更新日期：2005-09-01 00:00:00
abstract：:The debate over the nature of mechanisms leading to the establishment of synaptic specificity has engaged neuroscientists for the best part of a century. In this issue of Neuron, Balaskas et al. (2019) provide new evidence in favor of the role of positional strategies in the organization of sensory-motor circuits. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2019.05.046
更新日期：2019-06-19 00:00:00
abstract：:Retinal bipolar cells are essential to the transmission of light information. Although bipolar cell dysfunction can result in blindness, little is known about the factors required for bipolar cell development and functional maturation. The basic helix-loop-helix (bHLH) transcription factor Bhlhb4 was found to be expre...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.08.032
更新日期：2004-09-16 00:00:00
abstract：:Several aspects of perception, particularly those pertaining to vision, are closely linked to the occipital alpha (alpha) rhythm. However, how the alpha rhythm relates to the activity of neurons that convey primary visual information is unknown. Here we show that in behaving cats, thalamocortical neurons in the latera...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.08.012
更新日期：2009-09-10 00:00:00
abstract：:In this issue of Neuron, McGinty et al. (2013) report that the activity of cue-responsive neurons in the rat nucleus accumbens predicts the vigor of the subsequent approach movement. The characterization of this network state between motivation and action lends novel mechanistic insight to a spectrum of cue-elicited b...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2013.05.021
更新日期：2013-06-05 00:00:00
abstract：:Using a novel visual-tactile paradigm in rats, Nikbakht et al. (2018) describe multisensory behavior that outperformed predictions of optimal cue combination (indicating cross-modal synergy) and exposed encoding in PPC neurons (of stimulus and choice signals) that was independent of stimulus modality. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.01.041
更新日期：2018-02-07 00:00:00
abstract：:Commissural axons are attracted to the midline intermediate target by chemoattractants, but upon crossing the midline they switch off responsiveness to attractants and switch on responsiveness to midline repellents, which expel the axons from the midline and enable them to move on. Here we show that midline exit also ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.01.006
更新日期：2008-02-28 00:00:00
abstract：:Transmembrane channel-like (TMC) 1 and 2 are required for the mechanotransduction of mouse inner ear hair cells and localize to the site of mechanotransduction in mouse hair cell stereocilia. However, it remains unclear whether TMC1 and TMC2 are indeed ion channels and whether they can sense mechanical force directly....
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.10.017
更新日期：2020-01-22 00:00:00
abstract：UNLABELLED:Human induced pluripotent stem cells (iPSCs) from a healthy 86-year-old male were differentiated into neural stem cells and grafted into adult immunodeficient rats after spinal cord injury. Three months after C5 lateral hemisections, iPSCs survived and differentiated into neurons and glia and extended tens o...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.07.014
更新日期：2014-08-20 00:00:00
abstract：:Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data f...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(03)00681-0
更新日期：2003-10-30 00:00:00
abstract：:mRNAs for AMPA- and kainate-preferring glutamate receptor subunits are expressed abundantly in the CNS, yet functional studies of neurons and glia from brain suggest selective expression of AMPA receptors. We now show that glial cells of the O-2A lineage express rapidly desensitizing responses to kainate, mRNAs for Gl...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90277-1
更新日期：1994-02-01 00:00:00
abstract：:Learning can be characterized as the extraction of reliable predictions about stimulus occurrences from past experience. In two experiments, we investigated the interval of temporal integration of previous learning trials in different brain regions using implicit and explicit Pavlovian fear conditioning with a dynamic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.06.008
更新日期：2005-07-21 00:00:00
abstract：:Innate defensive responses are essential for animal survival and are conserved across species. The ventral tegmental area (VTA) plays important roles in learned appetitive and aversive behaviors, but whether it plays a role in mediating or modulating innate defensive responses is currently unknown. We report that VTAG...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.05.027
更新日期：2019-08-07 00:00:00
abstract：:The adipocyte-derived hormone leptin decreases body weight in part by activating the sympathetic nervous system, resulting in increased thermogenesis and energy expenditure. We investigated hypothalamic pathways underlying leptin's effects on stimulating the sympathetic nervous system. We found that leptin activates n...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80656-x
更新日期：1998-12-01 00:00:00
abstract：:We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90152-x
更新日期：1994-01-01 00:00:00
abstract：:Cysteine string protein alpha (CSPalpha)--an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40 chaperones--is thought to regulate Ca2+ channels and/or synaptic vesicle exocytosis. We now show that, in young mice, deletion of CSPalpha does not impair survival and causes no significa...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(04)00190-4
更新日期：2004-04-22 00:00:00
abstract：:The neural circuits governing vital behaviors, such as respiration and locomotion, are comprised of discrete neuronal populations residing within the brainstem and spinal cord. Work over the past decade has provided a fairly comprehensive understanding of the developmental pathways that determine the identity of major...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2013.09.020
更新日期：2013-10-02 00:00:00
abstract：:Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.09.006
更新日期：2008-09-25 00:00:00
abstract：:The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related defic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.11.030
更新日期：2010-12-22 00:00:00
abstract：:Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holorece...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.10.029
更新日期：2017-12-06 00:00:00
abstract：:Delineating the molecular basis of synapse development is crucial for understanding brain function. Cocultures of neurons with transfected fibroblasts have demonstrated the synapse-promoting activity of candidate molecules. Here, we performed an unbiased expression screen for synaptogenic proteins in the coculture ass...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.01.017
更新日期：2009-03-12 00:00:00
abstract：:N-type calcium channels play a dominant role in controlling synaptic transmission in many peripheral neurons. Transmitter release from mammalian central nerve terminals, however, is relatively resistant to the N channel antagonist omega-conotoxin GVIA. We studied the sensitivity of glutamatergic synaptic transmission ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90119-c
更新日期：1993-11-01 00:00:00
abstract：:Painful mechanical stimuli activate multiple peripheral sensory afferent subtypes simultaneously, including nociceptors and low-threshold mechanoreceptors (LTMRs). Using an optogenetic approach, we demonstrate that LTMRs do not solely serve as touch receptors but also play an important role in acute pain signaling. We...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.11.027
更新日期：2017-01-04 00:00:00
abstract：:Rodents begin to use bilaterally coordinated, rhythmic sweeping of their vibrissae ("whisking") for environmental exploration around 2 weeks after birth. Whether (and how) the vibrissal control circuitry changes after birth is unknown, and the relevant premotor circuitry remains poorly characterized. Using a modified ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.11.010
更新日期：2013-01-23 00:00:00
