A monoclonal antibody that defines rostrocaudal gradients in the mammalian nervous system.

abstract：:In cerebellar Purkinje cell dendrites, heterosynaptic calcium signaling induced by the proximal climbing fiber (CF) input controls plasticity at distal parallel fiber (PF) synapses. The substrate and regulation of this long-range dendritic calcium signaling are poorly understood. Using high-speed calcium imaging, we e...

journal_title：Neuron

authors： Otsu Y,Marcaggi P,Feltz A,Isope P,Kollo M,Nusser Z,Mathieu B,Kano M,Tsujita M,Sakimura K,Dieudonné S

更新日期：2014-10-01 00:00:00

abstract：:Nearly 25 years ago, the shared interests of psychologists and biologists in understanding the neural basis of social behavior led to the inception of social neuroscience. In the past decade, this field has exploded, in large part due to the infusion of studies that use fMRI. At the same time, tensions have arisen abo...

journal_title：Neuron

authors： Stanley DA,Adolphs R

更新日期：2013-10-30 00:00:00

abstract：:Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor. A fundamental question in addiction biology is why exogenous opiate drugs have a high liability for inducing tolerance and addiction while native ligands do not. Studies indicate that highly addictive opiate d...

journal_title：Neuron

authors： Whistler JL,Chuang HH,Chu P,Jan LY,von Zastrow M

更新日期：1999-08-01 00:00:00

abstract：:Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...

journal_title：Neuron

authors： Quinlan EM,Lebel D,Brosh I,Barkai E

更新日期：2004-01-22 00:00:00

abstract：:People often perceive configurations rather than the elements they comprise, a bias that may emerge because configurations often predict outcomes. But how does the brain learn to associate configurations with outcomes and how does this learning differ from learning about individual elements? We combined behavior, rein...

journal_title：Neuron

authors： Duncan K,Doll BB,Daw ND,Shohamy D

更新日期：2018-05-02 00:00:00

abstract：:Neuron B19 of Helisoma is selective in synaptogenesis. Presynaptic mechanisms underlying this selectivity were tested. Acetylcholine-sensitive assay cells were micromanipulated into contact with B19 somata to assess its secretory state. Prior to appropriate muscle target contact, spontaneous synaptic currents were det...

journal_title：Neuron

authors： Zoran MJ,Doyle RT,Haydon PG

更新日期：1991-01-01 00:00:00

abstract：:Membrane depolarization causes voltage-gated ion channels to transition from a resting/closed conformation to an activated/open conformation. We used voltage-clamp fluorometry to measure protein motion at specific regions of the Shaker Kv channel. This enabled us to construct new structural models of the resting/close...

journal_title：Neuron

authors： Pathak MM,Yarov-Yarovoy V,Agarwal G,Roux B,Barth P,Kohout S,Tombola F,Isacoff EY

更新日期：2007-10-04 00:00:00

abstract：:Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ ...

journal_title：Neuron

authors： Alcamo EA,Chirivella L,Dautzenberg M,Dobreva G,Fariñas I,Grosschedl R,McConnell SK

更新日期：2008-02-07 00:00:00

abstract：:Given a noisy sensory world, the nervous system integrates perceptual evidence over time to optimize decision-making. Neurophysiological accumulation of sensory information is well-documented in the animal visual system, but how such mechanisms are instantiated in the human brain remains poorly understood. Here we com...

journal_title：Neuron

authors： Bowman NE,Kording KP,Gottfried JA

更新日期：2012-09-06 00:00:00

abstract：:Nicotinic acetylcholine receptors (AChRs) immunoaffinity-purified from brains are composed of only two kinds of subunits rather than the four kinds present in muscle-type AChRs. Here we report the N-terminal protein sequences of the structural subunits of AChRs from rat and chicken brains and the cloning of full-lengt...

journal_title：Neuron

authors： Schoepfer R,Whiting P,Esch F,Blacher R,Shimasaki S,Lindstrom J

更新日期：1988-05-01 00:00:00

abstract：:The hippocampus is essential for spatiotemporal cognition. Sequences of neuronal activation provide a substrate for this fundamental function. At the behavioral timescale, these sequences have been shown to occur either in the presence of successive external landmarks or through internal mechanisms within an episodic ...

journal_title：Neuron

authors： Villette V,Malvache A,Tressard T,Dupuy N,Cossart R

更新日期：2015-10-21 00:00:00

abstract：:The neonatal mammal faces an array of sensory stimuli when diverse neuronal types have yet to form sensory maps. How these inputs interact with intrinsic neuronal activity to facilitate circuit assembly is not well understood. By using longitudinal calcium imaging in unanesthetized mouse pups, we show that layer I (LI...

journal_title：Neuron

authors： Che A,Babij R,Iannone AF,Fetcho RN,Ferrer M,Liston C,Fishell G,De Marco García NV

更新日期：2018-07-11 00:00:00

abstract：:Currents mediated by a glutamate transporter cloned from human motor cortex were measured in Xenopus oocytes. In the absence of glutamate, voltage jumps induced Na(+)-dependent capacitive currents that were blocked by kainate, a competitive transport antagonist. The pre-steady-state currents can be described by an ord...

journal_title：Neuron

authors： Wadiche JI,Arriza JL,Amara SG,Kavanaugh MP

更新日期：1995-05-01 00:00:00

abstract：:Reversible silencing of neuronal activity is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal excitation, for which the majority of studies have used a limited number of optogenetic and chemogenetic tools, the number of genetically...

journal_title：Neuron

authors： Wiegert JS,Mahn M,Prigge M,Printz Y,Yizhar O

更新日期：2017-08-02 00:00:00

abstract：:The ability of a neuronal surface glycoprotein to mediate the formation of neuronal connections was tested in an explant culture system. A monoclonal antibody against the limbic system-associated membrane protein (LAMP) was used in co-cultures containing cholinergic neurons of the septum and their hippocampal target n...

journal_title：Neuron

authors： Keller F,Rimvall K,Barbe MF,Levitt P

更新日期：1989-11-01 00:00:00

abstract：:Agrin is thought to mediate the motor neuron-induced aggregation of AChRs and AChE on the surface of muscle fibers at neuromuscular junctions. We have isolated a cDNA from a chick brain library that, based on sequence homology and expression experiments, codes for active agrin. Examination of the sequence reveals cons...

journal_title：Neuron

authors： Tsim KW,Ruegg MA,Escher G,Kröger S,McMahan UJ

更新日期：1992-04-01 00:00:00

abstract：:Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function; however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example, doublecortin (Dcx) knockdown but not knockout shows a neocortica...

journal_title：Neuron

authors： Baek ST,Kerjan G,Bielas SL,Lee JE,Fenstermaker AG,Novarino G,Gleeson JG

更新日期：2014-06-18 00:00:00

abstract：:Both the nucleus accumbens (NAc) and basolateral amygdala (BLA) contribute to learned behavioral choice. Neurons in both structures that encode reward-predictive cues may underlie the decision to respond to such cues, but the neural circuits by which the BLA influences reward-seeking behavior have not been established...

journal_title：Neuron

authors： Ambroggi F,Ishikawa A,Fields HL,Nicola SM

更新日期：2008-08-28 00:00:00

abstract：:The distribution of the synaptic vesicle-associated phosphoprotein synapsin I after electrical stimulation of the frog neuromuscular junction was investigated by immunogold labeling and compared with the distribution of the integral synaptic vesicle protein synaptophysin. In resting terminals both proteins were locali...

journal_title：Neuron

authors： Torri Tarelli F,Bossi M,Fesce R,Greengard P,Valtorta F

更新日期：1992-12-01 00:00:00

abstract：:Mammals are able to navigate to hidden goal locations by direct routes that may traverse previously unvisited terrain. Empirical evidence suggests that this "vector navigation" relies on an internal representation of space provided by the hippocampal formation. The periodic spatial firing patterns of grid cells in the...

journal_title：Neuron

authors： Bush D,Barry C,Manson D,Burgess N

更新日期：2015-08-05 00:00:00

abstract：:We review the central tenets and neuroanatomical basis of the global neuronal workspace (GNW) hypothesis, which attempts to account for the main scientific observations regarding the elementary mechanisms of conscious processing in the human brain. The GNW hypothesis proposes that, in the conscious state, a non-linear...

journal_title：Neuron

authors： Mashour GA,Roelfsema P,Changeux JP,Dehaene S

更新日期：2020-03-04 00:00:00

abstract：:The modulation of high voltage-activated (HVA) Ca2+ currents by L-glutamate and its agonists was investigated in cultured rat hypothalamic neurons. L-Glutamate and agonists selective for NMDA or non-NMDA receptors reversibly inhibited HVA Ca2+ currents. The putative presynaptic glutamate receptor agonist L-2-amino-4-p...

journal_title：Neuron

authors： Zeilhofer HU,Müller TH,Swandulla D

更新日期：1993-05-01 00:00:00

abstract：:The blood-brain barrier (BBB) poses a major challenge for developing effective antibody therapies for neurological diseases. Using transcriptomic and proteomic profiling, we searched for proteins in mouse brain endothelial cells (BECs) that could potentially be exploited to transport antibodies across the BBB. Due to ...

journal_title：Neuron

authors： Zuchero YJ,Chen X,Bien-Ly N,Bumbaca D,Tong RK,Gao X,Zhang S,Hoyte K,Luk W,Huntley MA,Phu L,Tan C,Kallop D,Weimer RM,Lu Y,Kirkpatrick DS,Ernst JA,Chih B,Dennis MS,Watts RJ

更新日期：2016-01-06 00:00:00

abstract：:Accurate motion detection requires neural circuitry that compensates for global visual field motion. Select subtypes of retinal ganglion cells perceive image motion and connect to the accessory optic system (AOS) in the brain, which generates compensatory eye movements that stabilize images during slow visual field mo...

journal_title：Neuron

authors： Sun LO,Brady CM,Cahill H,Al-Khindi T,Sakuta H,Dhande OS,Noda M,Huberman AD,Nathans J,Kolodkin AL

更新日期：2015-05-20 00:00:00

abstract：:We are rapidly approaching a better understanding of the mechanisms that allow our brains to form distinct representations for similar events or episodes. McHugh et al. have brought that goal one step closer by showing that NMDA receptor-dependent synaptic plasticity in the dentate gyrus is necessary for immediate dif...

journal_title：Neuron

authors： Leutgeb JK,Moser EI

更新日期：2007-07-19 00:00:00

abstract：:Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging g...

journal_title：Neuron

authors： Milham MP,Ai L,Koo B,Xu T,Amiez C,Balezeau F,Baxter MG,Blezer ELA,Brochier T,Chen A,Croxson PL,Damatac CG,Dehaene S,Everling S,Fair DA,Fleysher L,Freiwald W,Froudist-Walsh S,Griffiths TD,Guedj C,Hadj-Bouziane F,

更新日期：2018-10-10 00:00:00

abstract：:Spontaneous and sensory-evoked cortical activity is highly state-dependent, yet relatively little is known about transitions between distinct waking states. Patterns of activity in mouse V1 differ dramatically between quiescence and locomotion, but this difference could be explained by either motor feedback or a chang...

journal_title：Neuron

authors： Vinck M,Batista-Brito R,Knoblich U,Cardin JA

更新日期：2015-05-06 00:00:00

abstract：:The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for information processing in neural circuits. However, little is known about the spatial principles of E and I synaptic organization across the entire dendritic tree of mammalian neurons. We developed a new open-source reconstr...

journal_title：Neuron

authors： Iascone DM,Li Y,Sümbül U,Doron M,Chen H,Andreu V,Goudy F,Blockus H,Abbott LF,Segev I,Peng H,Polleux F

更新日期：2020-05-20 00:00:00

abstract：:Several cDNAs encoding an isoform of the alpha 1 subunit of the voltage-dependent calcium channel were isolated from rat brain cDNA libraries. The complete nucleotide sequence of 6975 bp encodes a protein of 1634 amino acids, which corresponds to an Mr of 186,968. The protein exhibits 71% and 76% homology to skeletal ...

journal_title：Neuron

authors： Hui A,Ellinor PT,Krizanova O,Wang JJ,Diebold RJ,Schwartz A

更新日期：1991-07-01 00:00:00

abstract：:Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we comprehensively identified each area's monosynaptic inputs using the rabies virus. We show that dopamine neurons in both areas integrate inp...

journal_title：Neuron

authors： Watabe-Uchida M,Zhu L,Ogawa SK,Vamanrao A,Uchida N

更新日期：2012-06-07 00:00:00