Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin.

abstract：:Coordination between sequential steps in synaptic vesicle endocytosis, including clathrin coat formation, fission, and uncoating, appears to involve proteinprotein interactions. Here, we show that compounds that disrupt interactions of the SH3 domain of endophilin with dynamin and synaptojanin impair synaptic vesicle ...

journal_title：Neuron

authors： Gad H,Ringstad N,Löw P,Kjaerulff O,Gustafsson J,Wenk M,Di Paolo G,Nemoto Y,Crun J,Ellisman MH,De Camilli P,Shupliakov O,Brodin L

更新日期：2000-08-01 00:00:00

abstract：:Two papers in the current issue of Neuron (Izuma et al. and Zink et al.) report that activity in specific regions of the brain, especially the striatum, reflects a common signal of reward in both the economic (e.g., money) and social (e.g., praise and status) domains. ...

journal_title：Neuron

authors： Saxe R,Haushofer J

更新日期：2008-04-24 00:00:00

abstract：:Neuropathic pain is caused by long-term modifications of neuronal function in the peripheral nervous system, the spinal cord, and supraspinal areas. Although functional changes in the forebrain are thought to contribute to the development of persistent pain, their significance and precise subcellular nature remain une...

journal_title：Neuron

authors： Santello M,Nevian T

更新日期：2015-04-08 00:00:00

abstract：:Brief bath application of N-methyl-D-aspartate (NMDA) to hippocampal slices produces long-term synaptic depression (LTD) in CA1 that is (1) sensitive to postnatal age, (2) saturable, (3) induced postsynaptically, (4) reversible, and (5) not associated with a change in paired pulse facilitation. Chemically induced LTD ...

journal_title：Neuron

authors： Lee HK,Kameyama K,Huganir RL,Bear MF

更新日期：1998-11-01 00:00:00

abstract：:Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation. Here we consider its roles in neuronal health and disease. We review evidence from mouse knockout studies demonstrating the normal functions of autophagy as a protective factor against neurodegeneration associated with...

journal_title：Neuron

authors： Menzies FM,Fleming A,Caricasole A,Bento CF,Andrews SP,Ashkenazi A,Füllgrabe J,Jackson A,Jimenez Sanchez M,Karabiyik C,Licitra F,Lopez Ramirez A,Pavel M,Puri C,Renna M,Ricketts T,Schlotawa L,Vicinanza M,Won H,Zhu Y,

更新日期：2017-03-08 00:00:00

abstract：:The slow (<1 Hz) rhythm is a defining feature of the electroencephalogram during sleep. Since cortical circuits can generate this rhythm in isolation, it is assumed that the accompanying slow oscillation in thalamocortical (TC) neurons is largely a passive reflection of neocortical activity. Here we show, however, tha...

journal_title：Neuron

authors： Hughes SW,Cope DW,Blethyn KL,Crunelli V

更新日期：2002-03-14 00:00:00

abstract：:Many activity-dependent changes in synaptic efficacy occur through elevations in postsynaptic calcium triggered by glutamate receptor activation. Here, the postsynaptic, neuron-specific microtubule-associated protein MAP2 is identified as a target of bidirectional calcium-dependent signaling pathways activated by glut...

journal_title：Neuron

authors： Quinlan EM,Halpain S

更新日期：1996-02-01 00:00:00

abstract：:Axon pruning by degeneration remodels exuberant axonal connections and is widely required for the development of proper circuitry in the nervous system from insects to mammals. Developmental axon degeneration morphologically resembles injury-induced Wallerian degeneration, suggesting similar underlying mechanisms. As ...

journal_title：Neuron

authors： Hoopfer ED,McLaughlin T,Watts RJ,Schuldiner O,O'Leary DD,Luo L

更新日期：2006-06-15 00:00:00

abstract：:The presynaptic function of myosin II was studied at cholinergic synapses formed between rat superior cervical ganglion neurons in culture. Immunofluorescent staining showed that myosin II was colocalized with synaptophysin at the presynaptic nerve terminals. Antimyosin II antibody introduced into presynaptic neurons ...

journal_title：Neuron

authors： Mochida S,Kobayashi H,Matsuda Y,Yuda Y,Muramoto K,Nonomura Y

更新日期：1994-11-01 00:00:00

abstract：:In this issue of Neuron, Gantz and Bean (2017) show that the endocannabinoid 2-arachidonoyl glycerol (2-AG) can directly alter the properties of native ion-channel Kv4.3 and accelerate the pacemaker activity of rodent dopamine neurons. These findings are one of the first demonstrations of postsynaptic, cell-autonomous...

journal_title：Neuron

authors： Matsui A,Alvarez VA

更新日期：2017-03-22 00:00:00

abstract：:The ability of vertebrates to detect and avoid damaging extremes of temperature depends on activation of ion channels belonging to the thermo-TRP family. Injury or inflammation causes the release of inflammatory mediators which lower the threshold for detection of painful levels of heat, a process known as heat hypera...

journal_title：Neuron

authors： Zhang X,Li L,McNaughton PA

更新日期：2008-08-14 00:00:00

abstract：:A meta-analysis of non-human primates performing three different tasks (Object-Match, Category-Match, and Category-Saccade associations) revealed signatures of explicit and implicit learning. Performance improved equally following correct and error trials in the Match (explicit) tasks, but it improved more after corre...

journal_title：Neuron

authors： Loonis RF,Brincat SL,Antzoulatos EG,Miller EK

更新日期：2017-10-11 00:00:00

abstract：:The ability of perisynaptic glial cells to modulate transmitter release and synaptic depression was studied at the frog neuromuscular junction (nmj). Injection of GTPgammaS in perisynaptic Schwann cells (PSCs), glial cells at this synapse, induced a reduction in the amplitude of nerve-evoked synaptic responses but had...

journal_title：Neuron

authors： Robitaille R

更新日期：1998-10-01 00:00:00

abstract：:It is a commonly held view that numbers are represented in an abstract way in both parietal lobes. This view is based on failures to find differences between various notational representations. Here we show that by using relatively smaller voxels together with an adaptation paradigm and analyzing subjects on an indivi...

journal_title：Neuron

authors： Cohen Kadosh R,Cohen Kadosh K,Kaas A,Henik A,Goebel R

更新日期：2007-01-18 00:00:00

abstract：:We have examined the influence of retinal innervation on the development of target neurons in the first optic ganglion, the lamina, of D. melanogaster. Mitotically active lamina precursor cells (LPCs), which normally produce lamina neurons, are absent in mutants that lack retinal innervation, while other proliferative...

journal_title：Neuron

authors： Selleck SB,Steller H

更新日期：1991-01-01 00:00:00

abstract：:We perceive motion when presented with spatiotemporal changes in contrast (second-order cue). This requires linear signals to be rectified and then summed in temporal order to compute direction. Although both operations have been attributed to cortex, rectification might occur in retina, prior to the ganglion cell. He...

journal_title：Neuron

authors： Demb JB,Zaghloul K,Sterling P

更新日期：2001-11-20 00:00:00

abstract：:Since the early days of research into language and the brain, word meaning was assumed to be processed in specific brain regions, which most modern neuroscientists localize to the left temporal lobe. Here we use event-related fMRI to show that action words referring to face, arm, or leg actions (e.g., to lick, pick, o...

journal_title：Neuron

authors： Hauk O,Johnsrude I,Pulvermüller F

更新日期：2004-01-22 00:00:00

abstract：:Pletikos et al. (2014) demonstrate in this issue of Neuron that the human neocortex has an "hourglass" temporal gene expression pattern with robust and dynamic transcriptome differences during the prenatal and adolescent/adult periods. Similar changes are not observed in the nonhuman primate-is this what makes us huma...

journal_title：Neuron

authors： Korade Z,Mirnics K

更新日期：2014-01-22 00:00:00

abstract：:We used the cerebellum as a model to study the morphogenetic and cellular processes underlying the formation of elaborate brain structures from a simple neural tube, using an inducible genetic fate mapping approach in mouse. We demonstrate how a 90 degrees rotation between embryonic days 9 and 12 converts the rostral-...

journal_title：Neuron

authors： Sgaier SK,Millet S,Villanueva MP,Berenshteyn F,Song C,Joyner AL

更新日期：2005-01-06 00:00:00

abstract：:The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is regulated during embryonic neural progenitor proliferation and neuronal migration through an inte...

journal_title：Neuron

authors： Singh KK,Ge X,Mao Y,Drane L,Meletis K,Samuels BA,Tsai LH

更新日期：2010-07-15 00:00:00

abstract：:The ability to classify visual objects into discrete categories ("friend" versus "foe"; "edible" versus "poisonous") is essential for survival and is a fundamental cognitive function. The cortical substrates that mediate this function, however, have not been identified in humans. To identify brain regions involved in ...

journal_title：Neuron

authors： Grinband J,Hirsch J,Ferrera VP

更新日期：2006-03-02 00:00:00

abstract：:Shaker potassium channels inactivate and recover from inactivation with multiple exponential components, suggesting the presence of multiple inactivation processes. We describe two different types of inactivation in Shaker potassium channels. N-type inactivation can occur as rapidly as a few milliseconds and has been ...

journal_title：Neuron

authors： Hoshi T,Zagotta WN,Aldrich RW

更新日期：1991-10-01 00:00:00

abstract：:Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In contrast to these animal models, most human narcolepsy is not familial, is discordant in identical twins, and has not been linked to mutations of the Hcrt system. Thus, the cause of human narc...

journal_title：Neuron

authors： Thannickal TC,Moore RY,Nienhuis R,Ramanathan L,Gulyani S,Aldrich M,Cornford M,Siegel JM

更新日期：2000-09-01 00:00:00

abstract：:Proteolipid protein (PLP) is an integral membrane protein of CNS myelin. Mutations of the X chromosome-linked PLP gene cause glial cell death and myelin deficiency in jimpy mice and other neurological mutants. As part of an attempt to rescue these mutants by transgenic complementation, we generated normal mouse lines ...

journal_title：Neuron

authors： Readhead C,Schneider A,Griffiths I,Nave KA

更新日期：1994-03-01 00:00:00

abstract：:The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RI...

journal_title：Neuron

authors： Ceni C,Barker PA

更新日期：2005-06-16 00:00:00

abstract：:GABARAP recognizes and binds the gamma2 subunit of the GABA(A) receptor, interacts with microtubules and the N-ethyl maleimide sensitive factor, and is proposed to function in GABA(A) receptor trafficking and postsynaptic localization. We have determined the crystal structure of human GABARAP at 1.6 A resolution. The ...

journal_title：Neuron

authors： Coyle JE,Qamar S,Rajashankar KR,Nikolov DB

更新日期：2002-01-03 00:00:00

abstract：:For efficient coding, sensory systems need to adapt to the distribution of signals to which they are exposed. In vision, natural scenes above and below the horizon differ in the distribution of chromatic and achromatic features. Consequently, many species differentially sample light in the sky and on the ground using ...

journal_title：Neuron

authors： Baden T,Schubert T,Chang L,Wei T,Zaichuk M,Wissinger B,Euler T

更新日期：2013-12-04 00:00:00

abstract：:In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...

journal_title：Neuron

authors： Grossmann T,Oberecker R,Koch SP,Friederici AD

更新日期：2010-03-25 00:00:00

abstract：:A fundamental question in developmental neuroscience is how a collection of progenitor cells proliferates and differentiates to create a brain of the appropriate size and cellular composition. To address this issue, we devised lineage-tracing assays in developing zebrafish embryos to reconstruct entire retinal lineage...

journal_title：Neuron

authors： He J,Zhang G,Almeida AD,Cayouette M,Simons BD,Harris WA

更新日期：2012-09-06 00:00:00

abstract：:The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a large increase in inhibitory, but not excitatory, neurotransmitter release, and potentiated the size, but not the properties, of ...

journal_title：Neuron

authors： Kaeser PS,Deng L,Chávez AE,Liu X,Castillo PE,Südhof TC

更新日期：2009-10-29 00:00:00