Modulation of synaptic efficacy and synaptic depression by glial cells at the frog neuromuscular junction.

abstract：:Memory enables flexible use of past experience to inform new behaviors. Although leading theories hypothesize that this fundamental flexibility results from the formation of integrated memory networks relating multiple experiences, the neural mechanisms that support memory integration are not well understood. Here, we...

journal_title：Neuron

authors： Zeithamova D,Dominick AL,Preston AR

更新日期：2012-07-12 00:00:00

abstract：:Argiotoxin, a component of the spider venom from Argiope lobata, blocks AMPA receptor channels expressed in homomeric and heteromeric configuration in Xenopus oocytes. Argiotoxin acts as an open channel blocker in a voltage-dependent manner and discriminates between the functionally diverse AMPA receptors. Importantly...

journal_title：Neuron

authors： Herlitze S,Raditsch M,Ruppersberg JP,Jahn W,Monyer H,Schoepfer R,Witzemann V

更新日期：1993-06-01 00:00:00

abstract：:Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the molecular and cellular mechanisms of this neuroplasticity, we investigated the effects of olfactory system activation on neurotransmitter (NT) expression in accessory olfactory bulb (AOB) interneurons...

journal_title：Neuron

authors： Dulcis D,Lippi G,Stark CJ,Do LH,Berg DK,Spitzer NC

更新日期：2017-09-13 00:00:00

abstract：:Axon pruning by degeneration remodels exuberant axonal connections and is widely required for the development of proper circuitry in the nervous system from insects to mammals. Developmental axon degeneration morphologically resembles injury-induced Wallerian degeneration, suggesting similar underlying mechanisms. As ...

journal_title：Neuron

authors： Hoopfer ED,McLaughlin T,Watts RJ,Schuldiner O,O'Leary DD,Luo L

更新日期：2006-06-15 00:00:00

abstract：:We have examined the long-term effects of notochord ablation at chick stages 9-10 on formation of the floor plate and motor neurons. Although missing or reduced 2 days postablation, the floor plate and motor neurons were morphologically normal by 4 postoperative days. When isolated whole or ventral, but not lateral, n...

journal_title：Neuron

authors： Artinger KB,Bronner-Fraser M

更新日期：1993-12-01 00:00:00

abstract：:The replay of previously stored memories during hippocampal sharp wave ripples (SWRs) is thought to support both memory retrieval and consolidation in distributed hippocampal-neocortical circuits. Replay events consist of precisely timed sequences of spikes from CA3 and CA1 neurons that are coordinated both within and...

journal_title：Neuron

authors： Carr MF,Karlsson MP,Frank LM

更新日期：2012-08-23 00:00:00

abstract：:The time course and functional significance of the structural changes associated with long-term facilitation of Aplysia sensory to motor neuron synaptic connections in culture were examined by time-lapse confocal imaging of individual sensory neuron varicosities labeled with three different fluorescent markers: the wh...

journal_title：Neuron

authors： Kim JH,Udo H,Li HL,Youn TY,Chen M,Kandel ER,Bailey CH

更新日期：2003-09-25 00:00:00

abstract：:Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional...

journal_title：Neuron

authors： Wager TD,Davidson ML,Hughes BL,Lindquist MA,Ochsner KN

更新日期：2008-09-25 00:00:00

abstract：:Synaptic homeostasis is a phenomenon that prevents the nervous system from descending into chaos. In this issue of Neuron, Frank et al. overturn the notion that synaptic homeostasis at Drosophila NMJs is a slow developmental process. They report that postsynaptic changes are offset within minutes by a homeostatic incr...

journal_title：Neuron

authors： Macleod GT,Zinsmaier KE

更新日期：2006-11-22 00:00:00

abstract：:Myelinated fibers are organized into distinct domains that are necessary for saltatory conduction. These domains include the nodes of Ranvier and the flanking paranodal regions where glial cells closely appose and form specialized septate-like junctions with axons. These junctions contain a Drosophila Neurexin IV-rela...

journal_title：Neuron

authors： Bhat MA,Rios JC,Lu Y,Garcia-Fresco GP,Ching W,St Martin M,Li J,Einheber S,Chesler M,Rosenbluth J,Salzer JL,Bellen HJ

更新日期：2001-05-01 00:00:00

abstract：:Binding between DIP and Dpr neuronal recognition proteins has been proposed to regulate synaptic connections between lamina and medulla neurons in the Drosophila visual system. Each lamina neuron was previously shown to express many Dprs. Here, we demonstrate, by contrast, that their synaptic partners typically expres...

journal_title：Neuron

authors： Cosmanescu F,Katsamba PS,Sergeeva AP,Ahlsen G,Patel SD,Brewer JJ,Tan L,Xu S,Xiao Q,Nagarkar-Jaiswal S,Nern A,Bellen HJ,Zipursky SL,Honig B,Shapiro L

更新日期：2018-12-19 00:00:00

abstract：:DREADDs are chemogenetic tools widely used to remotely control cellular signaling, neuronal activity, and behavior. Here we used a structure-based approach to develop a new Gi-coupled DREADD using the kappa-opioid receptor as a template (KORD) that is activated by the pharmacologically inert ligand salvinorin B (SALB)...

journal_title：Neuron

authors： Vardy E,Robinson JE,Li C,Olsen RHJ,DiBerto JF,Giguere PM,Sassano FM,Huang XP,Zhu H,Urban DJ,White KL,Rittiner JE,Crowley NA,Pleil KE,Mazzone CM,Mosier PD,Song J,Kash TL,Malanga CJ,Krashes MJ,Roth BL

更新日期：2015-05-20 00:00:00

abstract：:In this issue of Neuron, Vyazovskiy et al. reports on progressive changes in cortical unit activity within extended wakefulness and within extended sleep paralleling changes in EEG slow-wave sleep activity. Sleep debt may be integrated at the level of individual cortical neurons, providing support for the synaptic hom...

journal_title：Neuron

authors： Mignot E,Huguenard JR

更新日期：2009-09-24 00:00:00

abstract：:The primate dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) focus attention on relevant signals and suppress noise in cognitive tasks. However, their synaptic interactions and unique roles in cognitive control are unknown. We report that two distinct pathways to DLPFC area 9, one from the ne...

journal_title：Neuron

authors： Medalla M,Barbas H

更新日期：2009-02-26 00:00:00

abstract：:Screens for genes that orchestrate neural circuit formation in mammals have been hindered by practical constraints of germline mutagenesis. To overcome these limitations, we combined RNA-seq with somatic CRISPR mutagenesis to study synapse development in the mouse retina. Here synapses occur between cellular layers, f...

journal_title：Neuron

authors： Sarin S,Zuniga-Sanchez E,Kurmangaliyev YZ,Cousins H,Patel M,Hernandez J,Zhang KX,Samuel MA,Morey M,Sanes JR,Zipursky SL

更新日期：2018-04-04 00:00:00

abstract：:Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB(1) receptors and protecting against excitotoxicity. Such excitotoxic brain lesions initially result in primary destruction of brain parenchyma, which attracts macrophages and microglia. These inflammatory cells ...

journal_title：Neuron

authors： Eljaschewitsch E,Witting A,Mawrin C,Lee T,Schmidt PM,Wolf S,Hoertnagl H,Raine CS,Schneider-Stock R,Nitsch R,Ullrich O

更新日期：2006-01-05 00:00:00

abstract：:Neural ensembles oscillate across a broad range of frequencies and are transiently coupled or "bound" together when people attend to a stimulus, perceive, think, and act. This is a dynamic, self-assembling process, with parts of the brain engaging and disengaging in time. But how is it done? The theory of Coordination...

journal_title：Neuron

authors： Tognoli E,Kelso JA

更新日期：2014-01-08 00:00:00

abstract：:Human confidence judgments are thought to originate from metacognitive processes that provide a subjective assessment about one's beliefs. Alternatively, confidence is framed in mathematics as an objective statistical quantity: the probability that a chosen hypothesis is correct. Despite similar terminology, it remain...

journal_title：Neuron

authors： Sanders JI,Hangya B,Kepecs A

更新日期：2016-05-04 00:00:00

abstract：:Serotonergic neurons are thought to play a role in depression and obsessive compulsive disorder. However, their functional transmitter repertoire is incompletely known. To investigate this repertoire, intracellular recordings were obtained from 132 cytochemically identified rat mesopontine serotonergic neurons that ha...

journal_title：Neuron

authors： Johnson MD

更新日期：1994-02-01 00:00:00

abstract：:The neurotrophin survival dependence of peripheral neurons in vitro is regulated by the proapoptotic BCL-2 homolog BAX. To study peripheral neuron development in the absence of neurotrophin signaling, we have generated mice that are double null for BAX and nerve growth factor (NGF), and BAX and the NGF receptor TrkA. ...

journal_title：Neuron

authors： Patel TD,Jackman A,Rice FL,Kucera J,Snider WD

更新日期：2000-02-01 00:00:00

abstract：:alpha-tectorin is an extracellular matrix molecule of the inner ear. Mice homozygous for a targeted deletion in a-tectorin have tectorial membranes that are detached from the cochlear epithelium and lack all noncollagenous matrix, but the architecture of the organ of Corti is otherwise normal. The basilar membranes of...

journal_title：Neuron

authors： Legan PK,Lukashkina VA,Goodyear RJ,Kössi M,Russell IJ,Richardson GP

更新日期：2000-10-01 00:00:00

abstract：:Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excito...

journal_title：Neuron

authors： Ellerby LM

更新日期：2002-03-14 00:00:00

abstract：:Amphetamine (AMPH) releases monoamines, transiently stimulates locomotion, and inhibits feeding. Using a genetic approach, we show that mice lacking dopamine (DA-deficient, or DD, mice) are resistant to the hypophagic effects of a moderate dose of AMPH (2 microg/g) but manifest normal AMPH-induced hypophagia after res...

journal_title：Neuron

authors： Cannon CM,Abdallah L,Tecott LH,During MJ,Palmiter RD

更新日期：2004-10-28 00:00:00

abstract：:Recent genetic evidence indicates that neuregulin 1 (NRG1) and its receptor erbB4 may be susceptibility genes in schizophrenia, but their function in CNS synaptic transmission and circuitry is not well understood. In this issue of Neuron, studies from Li et al. and Woo et al. show that NRG1 and erbB4 regulate transmis...

journal_title：Neuron

authors： Fischbach GD

更新日期：2007-05-24 00:00:00

abstract：:Sympathetic neurons in culture die by apoptosis when deprived of nerve growth factor (NGF). We used this model of programmed cell death to study the mechanisms that mediate neuronal apoptosis. Cultured sympathetic neurons were injected with copper/zinc superoxide dismutase protein (SOD) or with an expression vector co...

journal_title：Neuron

authors： Greenlund LJ,Deckwerth TL,Johnson EM Jr

更新日期：1995-02-01 00:00:00

abstract：:Memory decline in aging results from multiple factors that influence both executive function and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems are preferentially vulnerable to white matter change, atrophy, and certain forms of neurotransmitter depletion. Frontal-striatal change ma...

journal_title：Neuron

authors： Buckner RL

更新日期：2004-09-30 00:00:00

abstract：:We used fMRI to investigate how moment-to-moment neural activity contributes to success or failure on individual trials of a visual working memory (WM) task. We found that different nodes of a distributed cortical network were activated to a greater extent for correct compared to incorrect trials during stimulus encod...

journal_title：Neuron

authors： Pessoa L,Gutierrez E,Bandettini P,Ungerleider L

更新日期：2002-08-29 00:00:00

abstract：:Basolateral amygdala and orbitofrontal cortex are implicated in cue-outcome learning. In this issue of Neuron, Schoenbaum et al. show that, following basolateral amygdala lesions, cue-selective neurons in orbitofrontal cortex are more sensory driven and less sensitive to the motivational value of an outcome, suggestin...

journal_title：Neuron

authors： O'Doherty J

更新日期：2003-08-28 00:00:00

abstract：:The neural basis of spatial processing in the auditory cortex has been controversial. Human fMRI studies suggest that a part of the planum temporale (PT) is involved in auditory spatial processing, but it was recently argued that this region is active only when the task requires voluntary spatial localization. If this...

journal_title：Neuron

authors： Deouell LY,Heller AS,Malach R,D'Esposito M,Knight RT

更新日期：2007-09-20 00:00:00

abstract：:Functional neuroimaging uses activity-dependent changes in cerebral blood flow to map brain activity, but the contributions of presynaptic and postsynaptic activity are incompletely understood, as are the underlying cellular pathways. Using intravital multiphoton microscopy, we measured presynaptic activity, postsynap...

journal_title：Neuron

authors： Petzold GC,Albeanu DF,Sato TF,Murthy VN

更新日期：2008-06-26 00:00:00