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NRG1 and synaptic function in the CNS.

Abstract：

:Recent genetic evidence indicates that neuregulin 1 (NRG1) and its receptor erbB4 may be susceptibility genes in schizophrenia, but their function in CNS synaptic transmission and circuitry is not well understood. In this issue of Neuron, studies from Li et al. and Woo et al. show that NRG1 and erbB4 regulate transmission at brain glutamate and GABA synapses. These findings raise the possibility of synaptic defects in schizophrenia.

journal_name

Neuron

journal_title

Neuron

authors

Fischbach GD

doi

10.1016/j.neuron.2007.05.009

subject

Has Abstract

pub_date

2007-05-24 00:00:00

pages

495-7

issue

4

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(07)00343-1

journal_volume

54

pub_type

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