Resting our cortices by going DOWN to sleep.

abstract：:During the development of forebrain connectivity, ascending thalamocortical and descending corticofugal axons first intermingle at the pallial-subpallial boundary to form the internal capsule (IC). However, the identity of molecular cues that guide these axons remains largely unknown. Here, we show that the transmembr...

journal_title：Neuron

authors： Mandai K,Reimert DV,Ginty DD

更新日期：2014-07-02 00:00:00

abstract：:The idea that memory is stored in the brain as physical alterations goes back at least as far as Plato, but further conceptualization of this idea had to wait until the 20(th) century when two guiding theories were presented: the "engram theory" of Richard Semon and Donald Hebb's "synaptic plasticity theory." While a ...

journal_title：Neuron

authors： Tonegawa S,Liu X,Ramirez S,Redondo R

更新日期：2015-09-02 00:00:00

abstract：:Sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis in its absence. We have investigated the pattern of expression of the Jun and Fos family of transcription factors in dying sympathetic neurons using antibodies specific for each family member. When sympathetic neurons are deprive...

journal_title：Neuron

authors： Ham J,Babij C,Whitfield J,Pfarr CM,Lallemand D,Yaniv M,Rubin LL

更新日期：1995-05-01 00:00:00

abstract：:Classical studies have related the spiking of selected neocortical neurons to behavior, but little is known about activity sampled from the entire neural population. We recorded from neurons selected independent of spiking, using cell-attached recordings and two-photon calcium imaging, in the barrel cortex of mice per...

journal_title：Neuron

authors： O'Connor DH,Peron SP,Huber D,Svoboda K

更新日期：2010-09-23 00:00:00

abstract：:The visual cortex represents stimuli through the activity of neuronal populations. We measured the evolution of this activity in space and time by imaging voltage-sensitive dyes in cat area V1. Contrast-reversing stimuli elicit responses that oscillate at twice the stimulus frequency, indicating that signals originate...

journal_title：Neuron

authors： Benucci A,Frazor RA,Carandini M

更新日期：2007-07-05 00:00:00

abstract：:Neuromodulators regulate circuits throughout the nervous system, and revealing the cell types and stimulus conditions controlling their release is vital to understanding their function. The effects of the neuromodulator nitric oxide (NO) have been studied in many circuits, including in the vertebrate retina, where it ...

journal_title：Neuron

authors： Jacoby J,Nath A,Jessen ZF,Schwartz GW

更新日期：2018-12-05 00:00:00

abstract：:It has recently been found that caspases not only function in apoptosis, but are also crucial for nonapoptotic processes such as NMDA receptor-dependent long-term depression (LTD) of synaptic transmission. It remains unknown, however, how caspases are activated and how neurons escape death in LTD. Here we show that ca...

journal_title：Neuron

authors： Jiao S,Li Z

更新日期：2011-05-26 00:00:00

abstract：:Mouse vision is based on the parallel output of more than 30 functional types of retinal ganglion cells (RGCs). Little is known about how representations of visual information change between retina and dorsolateral geniculate nucleus (dLGN) of the thalamus, the main relay between retina and cortex. Here, we functional...

journal_title：Neuron

authors： Román Rosón M,Bauer Y,Kotkat AH,Berens P,Euler T,Busse L

更新日期：2019-04-17 00:00:00

abstract：:We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...

journal_title：Neuron

authors： Maconochie DJ,Zempel JM,Steinbach JH

更新日期：1994-01-01 00:00:00

abstract：:Sexually dimorphic behaviors are likely to involve neural pathways that express the androgen receptor (AR). We have genetically modified the AR locus to visualize dimorphisms in neuronal populations that express AR. Analysis of AR-positive neurons reveals both known dimorphisms in the preoptic area of the hypothalamus...

journal_title：Neuron

authors： Shah NM,Pisapia DJ,Maniatis S,Mendelsohn MM,Nemes A,Axel R

更新日期：2004-08-05 00:00:00

abstract：:In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarchin...

journal_title：Neuron

authors： Waxman SG

更新日期：2010-06-10 00:00:00

abstract：:Given that cocaine induces neuroadaptations through regulation of gene expression, we investigated whether chromatin remodeling at specific gene promoters may be a key mechanism. We show that cocaine induces specific histone modifications at different gene promoters in striatum, a major neural substrate for cocaine's ...

journal_title：Neuron

authors： Kumar A,Choi KH,Renthal W,Tsankova NM,Theobald DE,Truong HT,Russo SJ,Laplant Q,Sasaki TS,Whistler KN,Neve RL,Self DW,Nestler EJ

更新日期：2005-10-20 00:00:00

abstract：:Previous research suggests that synchronous neural activity underlies perceptual grouping of visual image features. The generality of this mechanism is unclear, however, as previous studies have focused on pairs of neurons with overlapping or collinear receptive fields. By sampling more broadly and employing stimuli t...

journal_title：Neuron

authors： Palanca BJ,DeAngelis GC

更新日期：2005-04-21 00:00:00

abstract：:The location, size, and number of synapses critically influence the specificity and strength of neural connections. In axons, synaptic vesicle (SV) and active zone (AZ) proteins are transported by molecular motors and accumulate at discrete presynaptic loci. Little is known about the mechanisms coordinating presynapti...

journal_title：Neuron

authors： Wu YE,Huo L,Maeder CI,Feng W,Shen K

更新日期：2013-06-19 00:00:00

abstract：:During normal vision, the focus of gaze continually jumps from one important image feature to the next. In this issue of Neuron, Mazer and Gallant analyze neural activity in higher-level visual cortex during this kind of active visual exploration, and they demonstrate a localized enhancement of visual responses that p...

journal_title：Neuron

authors： Connor CE

更新日期：2003-12-18 00:00:00

abstract：:At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic nerve to the brain. Available strategies of promoting axon regeneration act on only some of these types. Here we tested the hypothesis that overexpressing developmentally important transcription factors in adult RGCs could repr...

journal_title：Neuron

authors： Norsworthy MW,Bei F,Kawaguchi R,Wang Q,Tran NM,Li Y,Brommer B,Zhang Y,Wang C,Sanes JR,Coppola G,He Z

更新日期：2017-06-21 00:00:00

abstract：:We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR5(2b,) GluR5(2c), and GluR6. Of these, we show that both GRIP and PICK1 interactions are required to maintain KAR-mediated synaptic function at mossy fiber-CA3 synapses. In a...

journal_title：Neuron

authors： Hirbec H,Francis JC,Lauri SE,Braithwaite SP,Coussen F,Mulle C,Dev KK,Coutinho V,Meyer G,Isaac JT,Collingridge GL,Henley JM

更新日期：2003-02-20 00:00:00

abstract：:Successful visual navigation requires a sense of the geometry of the local environment. How do our brains extract this information from retinal images? Here we visually presented scenes with all possible combinations of five scene-bounding elements (left, right, and back walls; ceiling; floor) to human subjects during...

journal_title：Neuron

authors： Henriksson L,Mur M,Kriegeskorte N

更新日期：2019-07-03 00:00:00

abstract：:A male zebra finch learns a song by listening to a tutor, but song learning is normally restricted to a critical period in juvenile development. Here we identify an RNA whose expression in the song control circuit is altered during this critical period. The RNA encodes a soluble presynaptic protein that forms a predic...

journal_title：Neuron

authors： George JM,Jin H,Woods WS,Clayton DF

更新日期：1995-08-01 00:00:00

abstract：:Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and expli...

journal_title：Neuron

authors： Plath N,Ohana O,Dammermann B,Errington ML,Schmitz D,Gross C,Mao X,Engelsberg A,Mahlke C,Welzl H,Kobalz U,Stawrakakis A,Fernandez E,Waltereit R,Bick-Sander A,Therstappen E,Cooke SF,Blanquet V,Wurst W,Salmen B,Bösl

更新日期：2006-11-09 00:00:00

abstract：:Outer hair cells (OHCs) provide amplification in the mammalian cochlea using somatic force generation underpinned by voltage-dependent conformational changes of the motor protein prestin. However, prestin must be gated by changes in membrane potential on a cycle-by-cycle basis and the periodic component of the recepto...

journal_title：Neuron

authors： Johnson SL,Beurg M,Marcotti W,Fettiplace R

更新日期：2011-06-23 00:00:00

abstract：:Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the molecular and cellular mechanisms of this neuroplasticity, we investigated the effects of olfactory system activation on neurotransmitter (NT) expression in accessory olfactory bulb (AOB) interneurons...

journal_title：Neuron

authors： Dulcis D,Lippi G,Stark CJ,Do LH,Berg DK,Spitzer NC

更新日期：2017-09-13 00:00:00

abstract：:Spine Ca(2+) is critical for the induction of synaptic plasticity, but the factors that control Ca(2+) handling in dendritic spines under physiological conditions are largely unknown. We studied [Ca(2+)] signaling in dendritic spines of CA1 pyramidal neurons and find that spines are specialized structures with low end...

journal_title：Neuron

authors： Sabatini BL,Oertner TG,Svoboda K

更新日期：2002-01-31 00:00:00

abstract：:We show here that antisense MAP2 oligonucleotides inhibit neurite outgrowth in cultured cerebellar macroneurons. Unlike control neurons, which first extend a lamellipodial veil followed by a consolidation phase during which the cells extend minor neurites, MAP2-suppressed cells persist with lamellipodia and later beco...

journal_title：Neuron

authors： Caceres A,Mautino J,Kosik KS

更新日期：1992-10-01 00:00:00

abstract：:Acquisition of new learning is challenged by the phenomenon of proactive interference (PI), which occurs when previous learning disrupts later learning. Whereas human neuroimaging studies have focused on the cortical contributions to interference resolution, animal studies demonstrate that efficient resolution of PI d...

journal_title：Neuron

authors： De Rosa E,Desmond JE,Anderson AK,Pfefferbaum A,Sullivan EV

更新日期：2004-03-04 00:00:00

abstract：:In the developing mammalian visual system, retinal fibers grow through the optic chiasm, where one population crosses to the opposite side of the brain and the other does not. Evidence from labeling growing retinal axons with the carbocyanine dye Dil in mouse embryos indicates that the two subpopulations diverge at a ...

journal_title：Neuron

authors： Godement P,Salaün J,Mason CA

更新日期：1990-08-01 00:00:00

abstract：:The apical tuft of layer 5 pyramidal neurons is innervated by a large number of inhibitory inputs with unknown functions. Here, we studied the functional consequences and underlying molecular mechanisms of apical inhibition on dendritic spike activity. Extracellular stimulation of layer 1, during blockade of glutamate...

journal_title：Neuron

authors： Pérez-Garci E,Gassmann M,Bettler B,Larkum ME

更新日期：2006-05-18 00:00:00

abstract：:Today we are witnessing a new science of placebo, a complex discipline that encompasses several experimental approaches and translational implications. Modern neurobiological tools have been used to answer important questions in placebo research, such as the top-down modulation of sensory and motor systems as well as ...

journal_title：Neuron

authors： Benedetti F

更新日期：2014-11-05 00:00:00

abstract：:Brain functions are based on the dynamic interaction of excitatory and inhibitory inputs. Spillover of glutamate from excitatory synapses may diffuse to and modulate nearby inhibitory synapses. By recording unitary inhibitory postsynaptic currents (uIPSCs) from cell pairs in CA1 of the hippocampus, we demonstrated tha...

journal_title：Neuron

authors： Jiang L,Xu J,Nedergaard M,Kang J

更新日期：2001-05-01 00:00:00

abstract：:Neuromodulators are important regulators of synaptic transmission throughout the brain. At the presynaptic terminal, neuromodulation of calcium channels (CaVs) can affect transmission not only by changing neurotransmitter release probability, but also by shaping short-term plasticity (STP). Indeed, changes in STP are ...

journal_title：Neuron

authors： Burke KJ Jr,Keeshen CM,Bender KJ

更新日期：2018-09-05 00:00:00