Abstract：
:Sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis in its absence. We have investigated the pattern of expression of the Jun and Fos family of transcription factors in dying sympathetic neurons using antibodies specific for each family member. When sympathetic neurons are deprived of NGF, the level of c-Jun protein significantly increases, whereas the levels of the other members of the Jun and Fos family remain relatively constant. c-Jun also becomes more phosphorylated, probably on its amino terminal transactivation domain. When microinjected into sympathetic neurons, an expression vector for a c-Jun dominant negative mutant protects them against NGF withdrawal-induced death, indicating that AP-1 activity is essential for neuronal cell death. Furthermore, overexpression of the full-length c-Jun protein is, in itself, sufficient to induce apoptosis in sympathetic neurons.
journal_name
Neuronjournal_title
Neuronauthors
Ham J,Babij C,Whitfield J,Pfarr CM,Lallemand D,Yaniv M,Rubin LLdoi
10.1016/0896-6273(95)90331-3subject
Has Abstractpub_date
1995-05-01 00:00:00pages
927-39issue
5eissn
0896-6273issn
1097-4199pii
0896-6273(95)90331-3journal_volume
14pub_type
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