All asleep-but inhibition is wide awake.

abstract：:Studies of resting-state activity in the brain have provoked critical questions about the brain's functional organization, but the biological basis of this activity is not clear. Specifically, the relationships between interregional correlations in resting-state measures of activity, neuronal functional connectivity a...

journal_title：Neuron

authors： Wang Z,Chen LM,Négyessy L,Friedman RM,Mishra A,Gore JC,Roe AW

更新日期：2013-06-19 00:00:00

abstract：:Light plays a pivotal role in the regulation of affective behaviors. However, the precise circuits that mediate the impact of light on depressive-like behaviors are not well understood. Here, we show that light influences depressive-like behaviors through a disynaptic circuit linking the retina and the lateral habenul...

journal_title：Neuron

authors： Huang L,Xi Y,Peng Y,Yang Y,Huang X,Fu Y,Tao Q,Xiao J,Yuan T,An K,Zhao H,Pu M,Xu F,Xue T,Luo M,So KF,Ren C

更新日期：2019-04-03 00:00:00

abstract：:Recent studies indicate that long interspersed nuclear element-1 (L1) are mobilized in the genome of human neural progenitor cells and enhanced in Rett syndrome and ataxia telangiectasia. However, whether aberrant L1 retrotransposition occurs in mental disorders is unknown. Here, we report high L1 copy number in schiz...

journal_title：Neuron

authors： Bundo M,Toyoshima M,Okada Y,Akamatsu W,Ueda J,Nemoto-Miyauchi T,Sunaga F,Toritsuka M,Ikawa D,Kakita A,Kato M,Kasai K,Kishimoto T,Nawa H,Okano H,Yoshikawa T,Kato T,Iwamoto K

更新日期：2014-01-22 00:00:00

abstract：UNLABELLED:Developmental dyslexia is a reading disorder, yet deficits also manifest in the magnocellular-dominated dorsal visual system. Uncertainty about whether visual deficits are causal or consequential to reading disability encumbers accurate identification and appropriate treatment of this common learning disabil...

journal_title：Neuron

authors： Olulade OA,Napoliello EM,Eden GF

更新日期：2013-07-10 00:00:00

abstract：:Neocortical excitatory and inhibitory neurons derive from distinct progenitor domains during embryonic development and migrate to their final positions, where they assemble into functional circuits. This process appears to be influenced by lineage relationships among locally born excitatory neurons, raising the intrig...

journal_title：Neuron

authors： Turrero García M,Mazzola E,Harwell CC

更新日期：2016-10-05 00:00:00

abstract：:The hippocampus frequently replays memories of past experiences during sharp-wave ripple (SWR) events. These events can represent spatial trajectories extending from the animal's current location to distant locations, suggesting a role in the evaluation of upcoming choices. While SWRs have been linked to learning and ...

journal_title：Neuron

authors： Singer AC,Carr MF,Karlsson MP,Frank LM

更新日期：2013-03-20 00:00:00

abstract：:Nearly 25 years ago, the shared interests of psychologists and biologists in understanding the neural basis of social behavior led to the inception of social neuroscience. In the past decade, this field has exploded, in large part due to the infusion of studies that use fMRI. At the same time, tensions have arisen abo...

journal_title：Neuron

authors： Stanley DA,Adolphs R

更新日期：2013-10-30 00:00:00

abstract：:Existing models of Huntington's disease posit that deficits in BDNF delivery to the striatum contribute to atrophy and motor impairment. In this issue of Neuron, Plotkin et al. (2014) show that BDNF delivery is normal but downstream signaling via TrkB and p75 is impaired, leading to corticostriatal synaptic dysfunctio...

journal_title：Neuron

authors： Parsons MP,Raymond LA

更新日期：2014-07-02 00:00:00

abstract：:We recently applied multiplexed seqFISH to profile expressions of hundreds of genes at the single-cell level in situ (Shah et al., 2016) and provided a map of spatial heterogeneity within each subregion, reconciling previously contradictory descriptions of CA1 at lower spatial resolutions. The accompanying Matters Ari...

journal_title：Neuron

authors： Shah S,Lubeck E,Zhou W,Cai L

更新日期：2017-05-17 00:00:00

abstract：:Lattice-like structures known as perineuronal nets (PNNs) are key components of the extracellular matrix (ECM). Once fully crystallized by adulthood, they are largely stable throughout life. Contrary to previous reports that PNNs inhibit processes involving plasticity, here we report that the dynamic regulation of PNN...

journal_title：Neuron

authors： Banerjee SB,Gutzeit VA,Baman J,Aoued HS,Doshi NK,Liu RC,Ressler KJ

更新日期：2017-07-05 00:00:00

abstract：:In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom ...

journal_title：Neuron

authors： Perisse E,Owald D,Barnstedt O,Talbot CB,Huetteroth W,Waddell S

更新日期：2016-06-01 00:00:00

abstract：:Feedback is a ubiquitous anatomical feature of sensory processing in vertebrates. In this issue of Neuron, two papers (Boyd et al., 2012, and Markopoulos et al., 2012) analyze the features of feedback from olfactory cortex to olfactory bulb. ...

journal_title：Neuron

authors： Oswald AM,Urban NN

更新日期：2012-12-20 00:00:00

abstract：:Theta oscillations reflect rhythmic inputs that continuously converge to the hippocampus during exploratory and memory-guided behavior. The theta-nested operations that organize hippocampal spiking could either occur regularly from one cycle to the next or be tuned on a cycle-by-cycle basis. To resolve this, we identi...

journal_title：Neuron

authors： Lopes-Dos-Santos V,van de Ven GM,Morley A,Trouche S,Campo-Urriza N,Dupret D

更新日期：2018-11-21 00:00:00

abstract：:The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related defic...

journal_title：Neuron

authors： Hoover BR,Reed MN,Su J,Penrod RD,Kotilinek LA,Grant MK,Pitstick R,Carlson GA,Lanier LM,Yuan LL,Ashe KH,Liao D

更新日期：2010-12-22 00:00:00

abstract：:Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding process...

journal_title：Neuron

authors： Kounios J,Smith RW,Yang W,Bachman P,D'Esposito M

更新日期：2001-01-01 00:00:00

abstract：:To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...

journal_title：Neuron

authors： Reddy LV,Koirala S,Sugiura Y,Herrera AA,Ko CP

更新日期：2003-10-30 00:00:00

abstract：:In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarchin...

journal_title：Neuron

authors： Waxman SG

更新日期：2010-06-10 00:00:00

abstract：:Homomeric assembly of Kir5.1, an inward-rectifying K+ channel subunit, is believed to be nonfunctional, although the subunit exists abundantly in the brain. We show that HEK293T cells cotransfected with Kir5.1 and PSD-95 exhibit a Ba(2+)-sensitive inward-rectifying K+ current. Kir5.1 coexpressed with PSD-95 located on...

journal_title：Neuron

authors： Tanemoto M,Fujita A,Higashi K,Kurachi Y

更新日期：2002-04-25 00:00:00

abstract：:Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in excitatory circuits. Memory formation in the brain is associated with synaptic remodeling, but how this affects PAPs and therefore extra...

journal_title：Neuron

authors： Henneberger C,Bard L,Panatier A,Reynolds JP,Kopach O,Medvedev NI,Minge D,Herde MK,Anders S,Kraev I,Heller JP,Rama S,Zheng K,Jensen TP,Sanchez-Romero I,Jackson CJ,Janovjak H,Ottersen OP,Nagelhus EA,Oliet SHR,Stewar

更新日期：2020-12-09 00:00:00

abstract：:Neurodegenerative diseases have been intensively studied, but a comprehensive understanding of their pathogenesis remains elusive. An increasing body of evidence suggests that non-cell-autonomous processes play critical roles during the initiation and spatiotemporal progression or propagation of the dominant pathology...

journal_title：Neuron

authors： Garden GA,La Spada AR

更新日期：2012-03-08 00:00:00

abstract：:Local neuronal networks that are responsible for walking are poorly characterized in mammals. Using an innovative approach to identify interneuron inputs onto motorneuron populations in a neonatal rodent spinal cord preparation, we have investigated the network responsible for left-right coordination of the hindlimbs....

journal_title：Neuron

authors： Butt SJ,Kiehn O

更新日期：2003-06-19 00:00:00

abstract：:Agrin is thought to mediate the motor neuron-induced aggregation of AChRs and AChE on the surface of muscle fibers at neuromuscular junctions. We have isolated a cDNA from a chick brain library that, based on sequence homology and expression experiments, codes for active agrin. Examination of the sequence reveals cons...

journal_title：Neuron

authors： Tsim KW,Ruegg MA,Escher G,Kröger S,McMahan UJ

更新日期：1992-04-01 00:00:00

abstract：:Telling time and anticipating when external events will happen is among the most important tasks the brain performs. Yet the neural mechanisms underlying timing remain elusive. One theory proposes that timing is a general and intrinsic computation of cortical circuits. We tested this hypothesis using electrical and op...

journal_title：Neuron

authors： Goel A,Buonomano DV

更新日期：2016-07-20 00:00:00

abstract：:Synaptic vesicles are tethered to the active zone where they are docked/primed so that they can fuse rapidly upon Ca(2+) influx. To directly study these steps at a CNS presynaptic terminal, we used total internal reflection fluorescence (TIRF) microscopy at the live isolated calyx of Held terminal and measured the mov...

journal_title：Neuron

authors： Midorikawa M,Sakaba T

更新日期：2015-11-04 00:00:00

abstract：:Humans can easily focus on one speaker in a multi-talker acoustic environment, but how different areas of the human auditory cortex (AC) represent the acoustic components of mixed speech is unknown. We obtained invasive recordings from the primary and nonprimary AC in neurosurgical patients as they listened to multi-t...

journal_title：Neuron

authors： O'Sullivan J,Herrero J,Smith E,Schevon C,McKhann GM,Sheth SA,Mehta AD,Mesgarani N

更新日期：2019-12-18 00:00:00

abstract：:Ventral midbrain dopamine (DA) is unambiguously involved in motivation and behavioral arousal, yet the contributions of other DA populations to these processes are poorly understood. Here, we demonstrate that the dorsal raphe nucleus DA neurons are critical modulators of behavioral arousal and sleep-wake patterning. U...

journal_title：Neuron

authors： Cho JR,Treweek JB,Robinson JE,Xiao C,Bremner LR,Greenbaum A,Gradinaru V

更新日期：2017-06-21 00:00:00

abstract：:We investigated the contribution of the inferior temporal (IT) cortical neurons to the active maintenance of internal representations. The activity of single neurons in the IT cortex was recorded while the monkeys performed a sequential-type associative memory task in which distractor stimuli interrupted the delay epo...

journal_title：Neuron

authors： Takeda M,Naya Y,Fujimichi R,Takeuchi D,Miyashita Y

更新日期：2005-12-08 00:00:00

abstract：:Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative disorder Huntington's disease (HD). The gene encoding huntingtin, HTT, and its dominantly inherited mutation were identified more than 20 years ago...

journal_title：Neuron

authors： Saudou F,Humbert S

更新日期：2016-03-02 00:00:00

abstract：:Chen et al present data describing millisecond interactions in a human hyperdirect pathway that connects the inferior frontal gyrus and the subthalamic nucleus. They study this circuit during a stop-signal task in the context of inhibitory control. ...

journal_title：Neuron

authors： Narayanan NS,Wessel JR,Greenlee JDW

更新日期：2020-05-20 00:00:00

abstract：:NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor-expressing cells, and the majority of native receptors are triheteromers containing two GluN1 and two different GluN2. In contrast to diheterome...

journal_title：Neuron

authors： Hansen KB,Ogden KK,Yuan H,Traynelis SF

更新日期：2014-03-05 00:00:00