Light-dependent translocation of visual arrestin regulated by the NINAC myosin III.

Abstract:

:The rhodopsin regulatory protein, visual arrestin, undergoes light-dependent trafficking in mammalian and Drosophila photoreceptor cells, though the mechanisms underlying these movements are poorly understood. In Drosophila, the movement of the visual arrestin, Arr2, functions in long-term adaptation and is dependent on interaction with phosphoinositides (PIs). However, the basis for the requirement for PIs for light-dependent shuttling was unclear. Here, we demonstrated that the dynamic trafficking of Arr2 into the phototransducing compartment, the rhabdomere, required the eye-enriched myosin III, NINAC. We showed that defects in ninaC resulted in a long-term adaptation phenotype similar to that which occurred in arr2 mutants. The interaction between Arr2 and NINAC was PI dependent and NINAC bound directly to PIs. These data demonstrate that the light-dependent translocation of Arr2 into the rhabdomeres requires PI-mediated interactions between Arr2 and the NINAC myosin III.

journal_name

Neuron

journal_title

Neuron

authors

Lee SJ,Montell C

doi

10.1016/j.neuron.2004.06.014

subject

Has Abstract

pub_date

2004-07-08 00:00:00

pages

95-103

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896627304003563

journal_volume

43

pub_type

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