Abstract:
:The rhodopsin regulatory protein, visual arrestin, undergoes light-dependent trafficking in mammalian and Drosophila photoreceptor cells, though the mechanisms underlying these movements are poorly understood. In Drosophila, the movement of the visual arrestin, Arr2, functions in long-term adaptation and is dependent on interaction with phosphoinositides (PIs). However, the basis for the requirement for PIs for light-dependent shuttling was unclear. Here, we demonstrated that the dynamic trafficking of Arr2 into the phototransducing compartment, the rhabdomere, required the eye-enriched myosin III, NINAC. We showed that defects in ninaC resulted in a long-term adaptation phenotype similar to that which occurred in arr2 mutants. The interaction between Arr2 and NINAC was PI dependent and NINAC bound directly to PIs. These data demonstrate that the light-dependent translocation of Arr2 into the rhabdomeres requires PI-mediated interactions between Arr2 and the NINAC myosin III.
journal_name
Neuronjournal_title
Neuronauthors
Lee SJ,Montell Cdoi
10.1016/j.neuron.2004.06.014subject
Has Abstractpub_date
2004-07-08 00:00:00pages
95-103issue
1eissn
0896-6273issn
1097-4199pii
S0896627304003563journal_volume
43pub_type
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