Abstract:
:Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the molecular and cellular mechanisms of this neuroplasticity, we investigated the effects of olfactory system activation on neurotransmitter (NT) expression in accessory olfactory bulb (AOB) interneurons during development. We show that protracted exposure to kin or non-kin odorants changes the number of dopamine (DA)- or gamma aminobutyric acid (GABA)-expressing neurons, with corresponding changes in attraction/aversion behavior. Changing the relative number of dopaminergic and GABAergic AOB interneurons or locally introducing DA or GABA receptor antagonists alters kinship preference. We then isolate AOB microRNAs (miRs) differentially regulated across these conditions. Inhibition of miR-375 and miR-200b reveals that they target Pax6 and Bcl11b to regulate the dopaminergic and GABAergic phenotypes. The results illuminate the role of NT switching governing experience-dependent social preference. VIDEO ABSTRACT.
journal_name
Neuronjournal_title
Neuronauthors
Dulcis D,Lippi G,Stark CJ,Do LH,Berg DK,Spitzer NCdoi
10.1016/j.neuron.2017.08.023subject
Has Abstractpub_date
2017-09-13 00:00:00pages
1319-1333.e5issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30738-9journal_volume
95pub_type
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