Fission and uncoating of synaptic clathrin-coated vesicles are perturbed by disruption of interactions with the SH3 domain of endophilin.

abstract：:A fundamental question in developmental neuroscience is how a collection of progenitor cells proliferates and differentiates to create a brain of the appropriate size and cellular composition. To address this issue, we devised lineage-tracing assays in developing zebrafish embryos to reconstruct entire retinal lineage...

journal_title：Neuron

authors： He J,Zhang G,Almeida AD,Cayouette M,Simons BD,Harris WA

更新日期：2012-09-06 00:00:00

abstract：:Whether cognitive representations are better conceived as language-based, symbolic representations or perceptually related, analog representations is a subject of debate. If cognitive processes parallel perceptual processes, then fundamental psychophysical laws should hold for each. To test this, we analyzed both beha...

journal_title：Neuron

authors： Nieder A,Miller EK

更新日期：2003-01-09 00:00:00

abstract：:von Recklinghausen's neurofibromatosis (NF1) is a common inherited human disease. The events leading to patient symptoms from inheritance of a defective NF1 gene are unknown. Since knowledge of the distribution of the normal NF1 gene product should improve understanding of the pathogenesis of the disease, we raised an...

journal_title：Neuron

authors： Daston MM,Scrable H,Nordlund M,Sturbaum AK,Nissen LM,Ratner N

更新日期：1992-03-01 00:00:00

abstract：:Circadian pacemaker neurons contain a molecular clock that oscillates with a period of approximately 24 hr, controlling circadian rhythms of behavior. Pacemaker neurons respond to visual system inputs for clock resetting, but, unlike other neurons, have not been reported to transmit rapid signals to their targets. Her...

journal_title：Neuron

authors： Mazzoni EO,Desplan C,Blau J

更新日期：2005-01-20 00:00:00

abstract：:To assess the necessary parameters for the growth of axons within the adult rat CNS, we have used intracerebral grafts of primary fibroblasts genetically engineered to express nerve growth factor (NGF). Following the implantation of NGF-producing primary fibroblasts within the striatum, cholinergic axons arising from ...

journal_title：Neuron

authors： Kawaja MD,Gage FH

更新日期：1991-12-01 00:00:00

abstract：:Neurons that release hypocretin/orexin modulate sleep, arousal, and energy homeostasis; the absence of hypocretin results in narcolepsy. Here we present data on the physiological characteristics of these cells, identified with GFP in transgenic mouse brain slices. Hypocretin-1 and -2 depolarized hypocretin neurons by ...

journal_title：Neuron

authors： Li Y,Gao XB,Sakurai T,van den Pol AN

更新日期：2002-12-19 00:00:00

abstract：:Acquisition of new learning is challenged by the phenomenon of proactive interference (PI), which occurs when previous learning disrupts later learning. Whereas human neuroimaging studies have focused on the cortical contributions to interference resolution, animal studies demonstrate that efficient resolution of PI d...

journal_title：Neuron

authors： De Rosa E,Desmond JE,Anderson AK,Pfefferbaum A,Sullivan EV

更新日期：2004-03-04 00:00:00

abstract：:To investigate the role of the entorhinal cortex in memory at a molecular level, we developed transgenic mice in which transgene expression was inducible and limited to the superficial layers of the medial entorhinal cortex, pre- and parasubiculum. We found that expression of a constitutively active mutant form of CaM...

journal_title：Neuron

authors： Yasuda M,Mayford MR

更新日期：2006-04-20 00:00:00

abstract：:The presynaptic function of myosin II was studied at cholinergic synapses formed between rat superior cervical ganglion neurons in culture. Immunofluorescent staining showed that myosin II was colocalized with synaptophysin at the presynaptic nerve terminals. Antimyosin II antibody introduced into presynaptic neurons ...

journal_title：Neuron

authors： Mochida S,Kobayashi H,Matsuda Y,Yuda Y,Muramoto K,Nonomura Y

更新日期：1994-11-01 00:00:00

abstract：:A male zebra finch learns a song by listening to a tutor, but song learning is normally restricted to a critical period in juvenile development. Here we identify an RNA whose expression in the song control circuit is altered during this critical period. The RNA encodes a soluble presynaptic protein that forms a predic...

journal_title：Neuron

authors： George JM,Jin H,Woods WS,Clayton DF

更新日期：1995-08-01 00:00:00

abstract：:Expression of rat TrkA in Xenopus spinal neurons confers responsiveness of these neurons to nerve growth factor (NGF) in assays of neuronal survival and growth cone chemotropism. Mutational analysis indicates that coactivation of phospholipase C-gamma (PLC-gamma) and phosphoinositide 3-kinase (PI3-kinase) by specific ...

journal_title：Neuron

authors： Ming G,Song H,Berninger B,Inagaki N,Tessier-Lavigne M,Poo M

更新日期：1999-05-01 00:00:00

abstract：:The intraparietal cortex is involved in the control of visually guided actions, like reach-to-grasp movements, which require extracting the 3D shape and position of objects from 2D retinal images. Using fMRI in behaving monkeys, we investigated the role of the intraparietal cortex in processing stereoscopic informatio...

journal_title：Neuron

authors： Durand JB,Nelissen K,Joly O,Wardak C,Todd JT,Norman JF,Janssen P,Vanduffel W,Orban GA

更新日期：2007-08-02 00:00:00

abstract：:Our tactile perception of external objects depends on skin-object interactions. The mechanics of contact dictates the existence of fundamental spatiotemporal input features-contact initiation and cessation, slip, and rolling contact-that originate from the fact that solid objects do not interpenetrate. However, it is ...

journal_title：Neuron

authors： Jörntell H,Bengtsson F,Geborek P,Spanne A,Terekhov AV,Hayward V

更新日期：2014-09-17 00:00:00

abstract：:While there are selective regions of occipitotemporal cortex that respond to faces, letters, and bodies, the large-scale neural organization of most object categories remains unknown. Here, we find that object representations can be differentiated along the ventral temporal cortex by their real-world size. In a functi...

journal_title：Neuron

authors： Konkle T,Oliva A

更新日期：2012-06-21 00:00:00

abstract：:In this issue of Neuron, Tufail et al. present an underlying mechanism for microglia-mediated elimination of virally transduced cells in the central nervous system. These findings could contribute to the development of improved gene therapies for various neurological disorders by exploring why microglia destroy viable...

journal_title：Neuron

authors： Pluvinage JV,Wyss-Coray T

更新日期：2017-02-08 00:00:00

abstract：:Synaptic activity induces changes in the number of dendritic spines. Here, we report a pathway of regulated endocytosis triggered by arcadlin, a protocadherin induced by electroconvulsive and other excitatory stimuli in hippocampal neurons. The homophilic binding of extracellular arcadlin domains activates TAO2beta, a...

journal_title：Neuron

authors： Yasuda S,Tanaka H,Sugiura H,Okamura K,Sakaguchi T,Tran U,Takemiya T,Mizoguchi A,Yagita Y,Sakurai T,De Robertis EM,Yamagata K

更新日期：2007-11-08 00:00:00

abstract：:The structural basis for the synthesis of specific proteins within distinct intraneuronal compartments is unknown. We studied the distribution of poly(A) mRNA within cultured cerebrocortical neurons using high resolution in situ hybridization to identify cytoskeletal components that may anchor mRNA. After 1 day in cul...

journal_title：Neuron

authors： Bassell GJ,Singer RH,Kosik KS

更新日期：1994-03-01 00:00:00

abstract：:Memories are about the past, but they serve the future. Memory research often emphasizes the former aspect: focusing on the functions that re-constitute (re-member) experience and elucidating the various types of memories and their interrelations, timescales, and neural bases. Here we highlight the prospective nature ...

journal_title：Neuron

authors： Nobre AC,Stokes MG

更新日期：2019-10-09 00:00:00

abstract：:Voltage-gated ion channels generate electrical signals in species from bacteria to man. Their voltage-sensing modules are responsible for initiation of action potentials and graded membrane potential changes in response to synaptic input and other physiological stimuli. Extensive structure-function studies, structure ...

journal_title：Neuron

authors： Catterall WA

更新日期：2010-09-23 00:00:00

abstract：:In daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate th...

journal_title：Neuron

authors： Rosa JM,Ruehle S,Ding H,Lagnado L

更新日期：2016-04-20 00:00:00

abstract：:Analysis of the Drosophila lark gene indicates that it encodes an RNA-binding protein that functions as a regulatory element of the circadian clock output pathway controlling adult eclosion. We now demonstrate that the lark RNA-binding protein oscillates in abundance during the circadian cycle; importantly, the phasin...

journal_title：Neuron

authors： McNeil GP,Zhang X,Genova G,Jackson FR

更新日期：1998-02-01 00:00:00

abstract：:Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are thought to be a regulator of such a process. We examined the effects of cadherin blockage on synaptogenesis in cultured hippocampal neurons. This blockade resulted in alterations of dendritic spin...

journal_title：Neuron

authors： Togashi H,Abe K,Mizoguchi A,Takaoka K,Chisaka O,Takeichi M

更新日期：2002-07-03 00:00:00

abstract：:Huntington's disease-like-2 (HDL2) is a phenocopy of Huntington's disease caused by CTG/CAG repeat expansion at the Junctophilin-3 (JPH3) locus. The mechanisms underlying HDL2 pathogenesis remain unclear. Here we developed a BAC transgenic mouse model of HDL2 (BAC-HDL2) that exhibits progressive motor deficits, select...

journal_title：Neuron

authors： Wilburn B,Rudnicki DD,Zhao J,Weitz TM,Cheng Y,Gu X,Greiner E,Park CS,Wang N,Sopher BL,La Spada AR,Osmand A,Margolis RL,Sun YE,Yang XW

更新日期：2011-05-12 00:00:00

abstract：:Astrocytes are complex bushy cells that serve important functions through close contacts between their processes and synapses. However, the spatial interactions and dynamics of astrocyte processes relative to synapses have proven problematic to study in adult living brain tissue. Here, we report a genetically targeted...

journal_title：Neuron

authors： Octeau JC,Chai H,Jiang R,Bonanno SL,Martin KC,Khakh BS

更新日期：2018-04-04 00:00:00

abstract：:Deciding when to exploit what is already known and when to explore new possibilities is crucial for adapting to novel and dynamic environments. Using reinforcement-based decision making, Costa et al. (2019) in this issue of Neuron find that neurons in the amygdala and ventral-striatum differentially signal the benefit...

journal_title：Neuron

authors： Reitich-Stolero T,Aberg KC,Paz R

更新日期：2019-08-07 00:00:00

abstract：:A longstanding debate in binocular rivalry literature is whether the perceptual competition in rivalry occurs at an early or late stage of visual processing. Central to this debate is the determination of the source of the competition. Overwhelming evidence exists that local interocular differences can lead to binocul...

journal_title：Neuron

authors： Carlson TA,He S

更新日期：2004-09-16 00:00:00

abstract：:Nociceptive terminals possess the elements for detecting, transmitting, and modulating noxious signals, thus being pivotal for pain sensation. Despite this, a functional description of the transduction process by the terminals, in physiological conditions, has not been fully achieved. Here, we studied how nociceptive ...

journal_title：Neuron

authors： Goldstein RH,Barkai O,Íñigo-Portugués A,Katz B,Lev S,Binshtok AM

更新日期：2019-05-22 00:00:00

abstract：:Each residue in and flanking the M2 membrane-spanning segment of the alpha subunit, from Glu-241 to Glu-262, was mutated to cysteine, and the mutant subunits were expressed together with wild-type beta, gamma, and delta subunits in Xenopus oocytes. Cysteines substituted for Glu-262, Leu-258, Val-255, Ser-252, Leu-251,...

journal_title：Neuron

authors： Akabas MH,Kaufmann C,Archdeacon P,Karlin A

更新日期：1994-10-01 00:00:00

abstract：:Two papers in the current issue of Neuron (Izuma et al. and Zink et al.) report that activity in specific regions of the brain, especially the striatum, reflects a common signal of reward in both the economic (e.g., money) and social (e.g., praise and status) domains. ...

journal_title：Neuron

authors： Saxe R,Haushofer J

更新日期：2008-04-24 00:00:00

abstract：:Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation and mechanotransduction have remained functionally undefined. Here we report our find...

journal_title：Neuron

authors： Zhao Q,Wu K,Geng J,Chi S,Wang Y,Zhi P,Zhang M,Xiao B

更新日期：2016-03-16 00:00:00