Abstract：
:The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a large increase in inhibitory, but not excitatory, neurotransmitter release, and potentiated the size, but not the properties, of the readily-releasable pool of vesicles at inhibitory synapses. Quantitative electron microscopy revealed that the ELKS2alpha deletion did not change the number of docked vesicles or other ultrastructural parameters of synapses, except for a small decrease in synaptic vesicle numbers. The ELKS2alpha deletion did, however, alter the excitatory/inhibitory balance and exploratory behaviors, possibly as a result of the increased synaptic inhibition. Thus, as opposed to previous studies indicating that ELKS2alpha is essential for mediating neurotransmitter release, our results suggest that ELKS2alpha normally restricts release and limits the size of the readily-releasable pool of synaptic vesicles at the active zone of inhibitory synapses.
journal_name
Neuronjournal_title
Neuronauthors
Kaeser PS,Deng L,Chávez AE,Liu X,Castillo PE,Südhof TCdoi
10.1016/j.neuron.2009.09.019subject
Has Abstractpub_date
2009-10-29 00:00:00pages
227-39issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(09)00719-3journal_volume
64pub_type
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