GABA excitation in the adult brain: a mechanism for excitation- neurogenesis coupling.

abstract：:Two studies in this issue of Neuron challenge widely held assumptions about the role of positive feedback in recurrent neuronal networks. Goldman shows that such feedback is not necessary for memory maintenance in a neural integrator, and Murphy and Miller show that it is not necessary for amplification of orientation...

journal_title：Neuron

authors： Ganguli S,Latham P

更新日期：2009-02-26 00:00:00

abstract：:The long-term depression (LTD) of parallel fiber (PF) synapses onto Purkinje cells plays a central role in motor learning. Endocannabinoid release and LTD induction both depend upon activation of the metabotropic glutamate receptor mGluR1, require postsynaptic calcium increases, are synapse specific, and have a simila...

journal_title：Neuron

authors： Safo PK,Regehr WG

更新日期：2005-11-23 00:00:00

abstract：:The developing retina generates spontaneous glutamatergic (stage III) waves of activity that sequentially recruit neighboring ganglion cells with opposite light responses (ON and OFF RGCs). This activity pattern is thought to help establish parallel ON and OFF pathways in downstream visual areas. The circuits that pro...

journal_title：Neuron

authors： Akrouh A,Kerschensteiner D

更新日期：2013-07-24 00:00:00

abstract：:Axon bifurcation results in the formation of sister branches, and divergent segregation of the sister branches is essential for efficient innervation of multiple targets. From a genetic mosaic screen, we find that a lethal mutation in the Drosophila Down syndrome cell adhesion molecule (Dscam) specifically perturbs se...

journal_title：Neuron

authors： Wang J,Zugates CT,Liang IH,Lee CH,Lee T

更新日期：2002-02-14 00:00:00

abstract：:Intracortical somatosensory interfaces have now entered the clinical domain. Darie et al. explore the implications of research published in Science Translational Medicine by Flesher et al. (2016), discuss how to design such a system given current technology, and question how to effectively communicate with users about...

journal_title：Neuron

authors： Darie R,Powell M,Borton D

更新日期：2017-02-22 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) have long been associated with proliferation in non-neural cells, although they are also expressed in postmitotic neurons. We demonstrate that insulin-like growth factor-1 (IGF-1) induces within seconds a large, tyrosine-kinase-dependent increase in calcium channel currents in cerebell...

journal_title：Neuron

authors： Blair LA,Marshall J

更新日期：1997-08-01 00:00:00

abstract：:A new study by Yao et al. in the current issue of Cell proposes that a novel vesicular protein, dubbed Flower, regulates endocytosis by controlling presynaptic Ca(2+) levels. This finding is intriguing not only for its implications for vesicle cycling, but also for the multitude of Ca(2+)-dependent processes at play i...

journal_title：Neuron

authors： Kuo SP,Trussell LO

更新日期：2009-09-10 00:00:00

abstract：:It has been unclear whether the hippocampus is uniquely important for episodic memory (memory for events that are specific to time and place) or whether the hippocampus is also important for learning and remembering facts (semantic memory). In two studies, we assessed the capacity for semantic memory in patients with ...

journal_title：Neuron

authors： Manns JR,Hopkins RO,Squire LR

更新日期：2003-04-10 00:00:00

abstract：:The ability of perisynaptic glial cells to modulate transmitter release and synaptic depression was studied at the frog neuromuscular junction (nmj). Injection of GTPgammaS in perisynaptic Schwann cells (PSCs), glial cells at this synapse, induced a reduction in the amplitude of nerve-evoked synaptic responses but had...

journal_title：Neuron

authors： Robitaille R

更新日期：1998-10-01 00:00:00

abstract：:Neurabin and spinophilin are homologous protein phosphatase 1 and actin binding proteins that regulate dendritic spine function. A yeast two-hybrid analysis using the coiled-coil domain of neurabin revealed an interaction with Lfc, a Rho GEF. Lfc was highly expressed in brain, where it interacted with either neurabin ...

journal_title：Neuron

authors： Ryan XP,Alldritt J,Svenningsson P,Allen PB,Wu GY,Nairn AC,Greengard P

更新日期：2005-07-07 00:00:00

abstract：:Inflammatory mediators act on peripheral sensory neurons to produce pain and hypersensitivity after tissue injury. In this issue of Neuron, Dina et al. report that inflammatory mediators, such as epinephrine and prostaglandins, appear to couple to specific G protein-coupled receptor signaling pathways through plastic ...

journal_title：Neuron

authors： Bhave G,Gereau RW 4th

更新日期：2003-08-14 00:00:00

abstract：:It has been postulated that selective temporal coordination between neurons and development of functional neuronal assemblies are fundamental for brain function and behavior. Still, there is little evidence that functionally relevant coordination emerges preferentially in neuronal assemblies directly controlling behav...

journal_title：Neuron

authors： Koralek AC,Costa RM,Carmena JM

更新日期：2013-09-04 00:00:00

abstract：:Dopamine is essential to cognitive functions. However, despite abundant studies demonstrating that dopamine neuron activity is related to reinforcement and motivation, little is known about what signals dopamine neurons convey to promote cognitive processing. We therefore examined dopamine neuron activity in monkeys p...

journal_title：Neuron

authors： Matsumoto M,Takada M

更新日期：2013-09-04 00:00:00

abstract：:Habits are notoriously difficult to break and, if broken, are usually replaced by new routines. To examine the neural basis of these characteristics, we recorded spike activity in cortical and striatal habit sites as rats learned maze tasks. Overtraining induced a shift from purposeful to habitual behavior. This shift...

journal_title：Neuron

authors： Smith KS,Graybiel AM

更新日期：2013-07-24 00:00:00

abstract：:We have studied the subcellular distribution of the alpha 1 and alpha 2 subunits of the dihydropyridine (DHP) receptor and ankyrin in rat skeletal muscle with immunofluorescence and immunogold labeling techniques. All three proteins were concentrated in the triad junction formed between the T-tubules and sarcoplasmic ...

journal_title：Neuron

authors： Flucher BE,Morton ME,Froehner SC,Daniels MP

更新日期：1990-09-01 00:00:00

abstract：:Spike timing-dependent synaptic plasticity (STDP) serves as a key cellular correlate of associative learning, which is facilitated by elevated attentional and emotional states involving activation of adrenergic signaling. At cellular levels, adrenergic signaling increases dendrite excitability, but the underlying mech...

journal_title：Neuron

authors： Liu Y,Cui L,Schwarz MK,Dong Y,Schlüter OM

更新日期：2017-01-18 00:00:00

abstract：:The hippocampus frequently replays memories of past experiences during sharp-wave ripple (SWR) events. These events can represent spatial trajectories extending from the animal's current location to distant locations, suggesting a role in the evaluation of upcoming choices. While SWRs have been linked to learning and ...

journal_title：Neuron

authors： Singer AC,Carr MF,Karlsson MP,Frank LM

更新日期：2013-03-20 00:00:00

abstract：:Which neurons in the brain "decide" to initiate particular behaviors in response to sensory information? In this issue of Neuron, two papers (Kohatsu et al. and von Philipsborn et al.) identify candidates in the courtship circuitry of Drosophila. The activity of these neurons is both regulated by sex pheromones and ne...

journal_title：Neuron

authors： Benton R

更新日期：2011-02-10 00:00:00

abstract：:mRNAs for AMPA- and kainate-preferring glutamate receptor subunits are expressed abundantly in the CNS, yet functional studies of neurons and glia from brain suggest selective expression of AMPA receptors. We now show that glial cells of the O-2A lineage express rapidly desensitizing responses to kainate, mRNAs for Gl...

journal_title：Neuron

authors： Patneau DK,Wright PW,Winters C,Mayer ML,Gallo V

更新日期：1994-02-01 00:00:00

abstract：:Cortical GABAergic interneurons have essential roles for information processing and their dysfunction is implicated in neuropsychiatric disorders. Transcriptional codes are elucidating mechanisms of interneuron specification in the MGE (a subcortical progenitor zone), which regulate their migration, integration, and f...

journal_title：Neuron

authors： Vogt D,Hunt RF,Mandal S,Sandberg M,Silberberg SN,Nagasawa T,Yang Z,Baraban SC,Rubenstein JL

更新日期：2014-04-16 00:00:00

abstract：:Sweet and bitter taste distinguishes good food sources from potential toxins, but what happens when these tastants are mixed? In this issue of Neuron, Jeong et al. (2013) show that in Drosophila, bitter compounds act through an extracellular odorant-binding protein to inhibit sweet-responsive neurons and block the res...

journal_title：Neuron

authors： Lvovskaya S,Smith DP

更新日期：2013-08-21 00:00:00

abstract：:The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Car...

journal_title：Neuron

authors： Gai Y,Liu Z,Cervantes-Sandoval I,Davis RL

更新日期：2016-05-04 00:00:00

abstract：:Using exome sequencing, we identified a p.R191Q amino acid change in the valosin-containing protein (VCP) gene in an Italian family with autosomal dominantly inherited amyotrophic lateral sclerosis (ALS). Mutations in VCP have previously been identified in families with Inclusion Body Myopathy, Paget disease, and Fron...

journal_title：Neuron

authors： Johnson JO,Mandrioli J,Benatar M,Abramzon Y,Van Deerlin VM,Trojanowski JQ,Gibbs JR,Brunetti M,Gronka S,Wuu J,Ding J,McCluskey L,Martinez-Lage M,Falcone D,Hernandez DG,Arepalli S,Chong S,Schymick JC,Rothstein J,Landi

更新日期：2010-12-09 00:00:00

abstract：:The field of motor pattern generation and motor control has progressed markedly in the last decade. There has been a revolutionary shift in thinking from hard-wired circuits to multifunctional networks. Yet, it is clear that we still have a long way to go before we understand how very large ensembles of neurons produc...

journal_title：Neuron

authors： Katz PS

更新日期：1996-02-01 00:00:00

abstract：:Sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis in its absence. We have investigated the pattern of expression of the Jun and Fos family of transcription factors in dying sympathetic neurons using antibodies specific for each family member. When sympathetic neurons are deprive...

journal_title：Neuron

authors： Ham J,Babij C,Whitfield J,Pfarr CM,Lallemand D,Yaniv M,Rubin LL

更新日期：1995-05-01 00:00:00

abstract：:In the hippocampus, gamma power modulation by the theta rhythm is interpreted as the signature of temporally coordinated inputs that reflect ongoing processing. In this issue of Neuron, Lopes-Dos-Santos et al. (2018) develop a new methodology demonstrating that theta cycles can be viewed as individual computational un...

journal_title：Neuron

authors： Bagur S,Benchenane K

更新日期：2018-11-21 00:00:00

abstract：:Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation. Here we consider its roles in neuronal health and disease. We review evidence from mouse knockout studies demonstrating the normal functions of autophagy as a protective factor against neurodegeneration associated with...

journal_title：Neuron

authors： Menzies FM,Fleming A,Caricasole A,Bento CF,Andrews SP,Ashkenazi A,Füllgrabe J,Jackson A,Jimenez Sanchez M,Karabiyik C,Licitra F,Lopez Ramirez A,Pavel M,Puri C,Renna M,Ricketts T,Schlotawa L,Vicinanza M,Won H,Zhu Y,

更新日期：2017-03-08 00:00:00

abstract：:Acetylcholinesterase (AChE) is concentrated at the vertebrate neuromuscular synapse. To determine whether increased transcript levels could underlie this selective accumulation, we employed a quantitative reverse transcription polymerase chain reaction-based assay to determine mRNA copy number in samples as small as s...

journal_title：Neuron

authors： Jasmin BJ,Lee RK,Rotundo RL

更新日期：1993-09-01 00:00:00

abstract：:During development of the peripheral nervous system (PNS), Schwann-cell-secreted gliomedin induces the clustering of Na+ channels at the edges of each myelin segment to form nodes of Ranvier. Here we show that bone morphogenetic protein-1 (BMP1)/Tolloid (TLD)-like proteinases confine Na+ channel clustering to these si...

journal_title：Neuron

authors： Eshed-Eisenbach Y,Devaux J,Vainshtein A,Golani O,Lee SJ,Feinberg K,Sukhanov N,Greenspan DS,Susuki K,Rasband MN,Peles E

更新日期：2020-06-03 00:00:00

abstract：:Human vision adapts to the contrast of patterns by changing its sensitivity, but the origins of this perceptual adaptation have been disputed. In this issue of Neuron, Solomon et al. show that contrast adaptation in the primate arises mostly in the retina for the magnocellular pathway and mostly in the cortex for the ...

journal_title：Neuron

authors： Baccus SA,Meister M

更新日期：2004-04-08 00:00:00