Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning.

abstract：:Homomeric assembly of Kir5.1, an inward-rectifying K+ channel subunit, is believed to be nonfunctional, although the subunit exists abundantly in the brain. We show that HEK293T cells cotransfected with Kir5.1 and PSD-95 exhibit a Ba(2+)-sensitive inward-rectifying K+ current. Kir5.1 coexpressed with PSD-95 located on...

journal_title：Neuron

authors： Tanemoto M,Fujita A,Higashi K,Kurachi Y

更新日期：2002-04-25 00:00:00

abstract：:Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly from the medial geniculate nucleus and indirectly from the auditory cortex. Here we show in the cortico-amygdala pathway that learned fear occludes electricall...

journal_title：Neuron

authors： Tsvetkov E,Carlezon WA,Benes FM,Kandel ER,Bolshakov VY

更新日期：2002-04-11 00:00:00

abstract：:A series of recent papers highlight a prominent role for ubiquitin in the formation and function of neural circuits. These new results focus attention on the molecular remodeling that occurs at various decision points in the life of growth cones and synapses. ...

journal_title：Neuron

authors： Murphey RK,Godenschwege TA

更新日期：2002-09-26 00:00:00

abstract：:Structure-function studies have identified key functional motifs in the acetylcholine receptor, including residues that contribute to the ion channel and to the ligand-binding sites. Little is known, however, about determinants of channel gating kinetics. To identify structural correlates of gating, we examined the st...

journal_title：Neuron

authors： Bouzat C,Bren N,Sine SM

更新日期：1994-12-01 00:00:00

abstract：:Although associative learning has been localized to specific brain areas in many animals, identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the first demonstration of long-term synaptic plasticity at the output site of the Drosophila mushroom body. Pairing an odor with activati...

journal_title：Neuron

authors： Hige T,Aso Y,Modi MN,Rubin GM,Turner GC

更新日期：2015-12-02 00:00:00

abstract：:A fundamental question about the neural correlates of attention concerns the earliest sensory processing stage that it can affect. We addressed this issue by recording magnetoencephalography (MEG) signals while subjects performed detection tasks, which required employment of spatial or nonspatial attention, in auditor...

journal_title：Neuron

authors： Poghosyan V,Ioannides AA

更新日期：2008-06-12 00:00:00

abstract：:In order to deal effectively with danger, it is imperative to know about it. This is what nociceptors do--these primary sensory neurons are specialized to detect intense stimuli and represent, therefore, the first line of defense against any potentially threatening or damaging environmental inputs. By sensing noxious ...

journal_title：Neuron

authors： Woolf CJ,Ma Q

更新日期：2007-08-02 00:00:00

abstract：:Opioids are commonly used as analgesics for severe pain, but their addictive potential has sparked a misuse epidemic. In this issue of Neuron, Keyes et al. (2020) examine the contributions of distinct paraventricular thalamus (PVT) outputs to contextual opioid memories. They identify a PVT→NAc→LH circuit essential for...

journal_title：Neuron

authors： Pribiag H,Lim BK

更新日期：2020-09-23 00:00:00

abstract：:GABA, the major inhibitory neurotransmitter in the mammalian brain, binds to GABAA receptors, which form chloride ion channels. The predicted structure of the GABAA receptor places a consensus phosphorylation site for cAMP-dependent protein kinase (PKA) on an intracellular domain of the channel. Phosphorylation by var...

journal_title：Neuron

authors： Porter NM,Twyman RE,Uhler MD,Macdonald RL

更新日期：1990-12-01 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synaptic plasticity and memory formation. Although significant progress has been made in understanding the role of postsynaptic CaMKII in synaptic plasticity, very little is known about its presynaptic functio...

journal_title：Neuron

authors： Ninan I,Arancio O

更新日期：2004-04-08 00:00:00

abstract：:Neurotransmitter receptors are central to communication at synapses. Many components of the machinery for neurotransmission are present prior to synapse formation, suggesting a developmental role. Here, evidence is presented that signaling through glycine receptor alpha2 (GlyRalpha2) and GABA(A) receptors plays a role...

journal_title：Neuron

authors： Young TL,Cepko CL

更新日期：2004-03-25 00:00:00

abstract：:The structural basis for the synthesis of specific proteins within distinct intraneuronal compartments is unknown. We studied the distribution of poly(A) mRNA within cultured cerebrocortical neurons using high resolution in situ hybridization to identify cytoskeletal components that may anchor mRNA. After 1 day in cul...

journal_title：Neuron

authors： Bassell GJ,Singer RH,Kosik KS

更新日期：1994-03-01 00:00:00

abstract：:In this issue of Neuron, Wahl et al. demonstrate via invasive recordings from Deep Brain Stimulation leads that the thalamus (but not basal ganglia) is sensitive to certain linguistic violations, consistent with a subcortical role in selective recruitment of language-related cortical areas. ...

journal_title：Neuron

authors： Münte TF,Kutas M

更新日期：2008-09-11 00:00:00

abstract：:There has been a surge of interest in how inhibitory neurons influence the output of local circuits in the brain. In this issue of Neuron, Scholl et al. (2015) provide a compelling argument for what one class of inhibitory neurons actually does. ...

journal_title：Neuron

authors： Trachtenberg JT

更新日期：2015-07-15 00:00:00

abstract：:A new fluorescence method using the dye FM1-43 was used to examine exocytotic release from hippocampal synaptosomes. Nitric oxide caused a marked transient stimulation of vesicle release. Several structurally unrelated nitric oxide donors, sodium nitroprusside, S-nitroso-N-acetylpenicillamine, 3-morpholino-sydnonimine...

journal_title：Neuron

authors： Meffert MK,Premack BA,Schulman H

更新日期：1994-06-01 00:00:00

abstract：:The histone deacetylase HDAC5 has been shown to regulate behavioral adaptations to cocaine. In this issue of Neuron, Taniguchi et al. (2012) describe a cAMP-dependent signaling pathway that regulates nuclear accumulation of HDAC5, suggesting a mechanism to couple cocaine with changes in HDAC5 function. ...

journal_title：Neuron

authors： West AE

更新日期：2012-01-12 00:00:00

abstract：:Relatively little is known about the neural circuitry underlying sex-specific behaviors. We have expressed the feminizing gene transformer in genetically defined subregions of the brain of male Drosophila, and in particular within different domains of the mushroom bodies. Mushroom bodies are phylogenetically conserved...

journal_title：Neuron

authors： O'Dell KM,Armstrong JD,Yang MY,Kaiser K

更新日期：1995-07-01 00:00:00

abstract：:What underlies the large variation in mEPSC amplitude in the auditory system? And is this variability important? In this issue of Neuron, Li et al. (2014) address the significance of large mEPSCs to auditory processing and Chapochnikov et al. (2014) describe a novel mechanism underlying them. ...

journal_title：Neuron

authors： Lv C,Zenisek D

更新日期：2014-09-17 00:00:00

abstract：:Respiration is a rhythmic activity as well as one that requires responsiveness to internal and external circumstances; both the rhythm and neuromodulatory responses of breathing are controlled by brainstem neurons in the preBötzinger complex (preBötC) and the retrotrapezoid nucleus (RTN), but the specific ion channels...

journal_title：Neuron

authors： Yeh SY,Huang WH,Wang W,Ward CS,Chao ES,Wu Z,Tang B,Tang J,Sun JJ,Esther van der Heijden M,Gray PA,Xue M,Ray RS,Ren D,Zoghbi HY

更新日期：2017-04-19 00:00:00

abstract：:Hippocampal pyramidal cells can be divided into place cells, which fire action potentials when an animal is in specific locations, and silent cells, which are not spatially selective. In this issue of Neuron, Epsztein et al. find intracellular differences between place and silent cells by using whole-cell recordings i...

journal_title：Neuron

authors： Ferguson JE,Jackson JC,Redish AD

更新日期：2011-04-14 00:00:00

abstract：:Existing models of Huntington's disease posit that deficits in BDNF delivery to the striatum contribute to atrophy and motor impairment. In this issue of Neuron, Plotkin et al. (2014) show that BDNF delivery is normal but downstream signaling via TrkB and p75 is impaired, leading to corticostriatal synaptic dysfunctio...

journal_title：Neuron

authors： Parsons MP,Raymond LA

更新日期：2014-07-02 00:00:00

abstract：:Information processing by a sensory system is reflected in the changes in stimulus representation along its successive processing stages. We measured information content and stimulus-induced redundancy in the neural responses to a set of natural sounds in three successive stations of the auditory pathway-inferior coll...

journal_title：Neuron

authors： Chechik G,Anderson MJ,Bar-Yosef O,Young ED,Tishby N,Nelken I

更新日期：2006-08-03 00:00:00

abstract：:Two studies in this issue of Neuron challenge widely held assumptions about the role of positive feedback in recurrent neuronal networks. Goldman shows that such feedback is not necessary for memory maintenance in a neural integrator, and Murphy and Miller show that it is not necessary for amplification of orientation...

journal_title：Neuron

authors： Ganguli S,Latham P

更新日期：2009-02-26 00:00:00

abstract：:Excessive grooming behaviors, cleansing rituals, and self-mutilation are important features of a range of neuropsychiatric diseases including obsessive compulsive (OC)-spectrum disorders. In this issue of Neuron, Greer and Capecchi (2002) report that Hoxb8 mutant mice exhibit this behavioral phenotype. These Hoxb8 mut...

journal_title：Neuron

authors： Graybiel AM,Saka E

更新日期：2002-01-03 00:00:00

abstract：:Properly functional CNS circuits depend on inhibitory interneurons that in turn rely upon activity-dependent gene expression for morphological development, connectivity, and excitatory-inhibitory coordination. Despite its importance, excitation-transcription coupling in inhibitory interneurons is poorly understood. We...

journal_title：Neuron

authors： Cohen SM,Ma H,Kuchibhotla KV,Watson BO,Buzsáki G,Froemke RC,Tsien RW

更新日期：2016-04-20 00:00:00

abstract：:Changes in the response to release of a single synaptic vesicle have generally been attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now demonstrates that alterations in vesicle filling also contribute to changes in quantal size. Receptors are not saturated at many synapses, a...

journal_title：Neuron

authors： Edwards RH

更新日期：2007-09-20 00:00:00

abstract：:We report that EphB receptors direct unique axonal behaviors required for mapping the dorsal-ventral (D-V) retinal axis along the lateral-medial (L-M) axis of the superior colliculus (SC). EphBs are expressed in a D-V gradient, ephrin-B1 in a L-M gradient in SC, and ephrin-B3 at its midline. EphBs and ephrin-Bs are ex...

journal_title：Neuron

authors： Hindges R,McLaughlin T,Genoud N,Henkemeyer M,O'Leary D

更新日期：2002-08-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Aβ₄₂ are established biomarkers for Alzheimer's disease (AD) and have been used as quantitative traits for genetic analyses. We performed the largest genome-wide association study for cerebrospinal fluid (CSF) tau/ptau levels published to d...

journal_title：Neuron

authors： Cruchaga C,Kauwe JS,Harari O,Jin SC,Cai Y,Karch CM,Benitez BA,Jeng AT,Skorupa T,Carrell D,Bertelsen S,Bailey M,McKean D,Shulman JM,De Jager PL,Chibnik L,Bennett DA,Arnold SE,Harold D,Sims R,Gerrish A,Williams J

更新日期：2013-04-24 00:00:00

abstract：:Cortical GABAergic interneurons have essential roles for information processing and their dysfunction is implicated in neuropsychiatric disorders. Transcriptional codes are elucidating mechanisms of interneuron specification in the MGE (a subcortical progenitor zone), which regulate their migration, integration, and f...

journal_title：Neuron

authors： Vogt D,Hunt RF,Mandal S,Sandberg M,Silberberg SN,Nagasawa T,Yang Z,Baraban SC,Rubenstein JL

更新日期：2014-04-16 00:00:00

abstract：:Nociceptive terminals possess the elements for detecting, transmitting, and modulating noxious signals, thus being pivotal for pain sensation. Despite this, a functional description of the transduction process by the terminals, in physiological conditions, has not been fully achieved. Here, we studied how nociceptive ...

journal_title：Neuron

authors： Goldstein RH,Barkai O,Íñigo-Portugués A,Katz B,Lev S,Binshtok AM

更新日期：2019-05-22 00:00:00