Abstract：
:A new fluorescence method using the dye FM1-43 was used to examine exocytotic release from hippocampal synaptosomes. Nitric oxide caused a marked transient stimulation of vesicle release. Several structurally unrelated nitric oxide donors, sodium nitroprusside, S-nitroso-N-acetylpenicillamine, 3-morpholino-sydnonimine, and acidified sodium nitrite, were effective. Release stimulated by nitric oxide and KCl were comparable in time course, using both the fluorescence assay and [3H]L-glutamate to monitor neurotransmitter release. Activation of guanylyl cyclase was not responsible for nitric oxide-stimulated release. Unlike release stimulated by KCl or A23187, nitric oxide-stimulated release was found to be independent of a rise in intrasynaptosomal Ca2+. Indo-1/AM measurements indicated that nitric oxide actually decreased intracellular Ca2+, and the Ca2+ channel blocker Cd2+ did not affect nitric oxide-stimulated vesicle release. Nitric oxide does, however, appear to act on the Ca(2+)-sensitive pool of vesicles. Nitric oxide may be the first physiological mediator that induces vesicle exocytosis without raising Ca2+ and may provide an interesting new tool for the study of molecules involved in vesicle exocytosis.
journal_name
Neuronjournal_title
Neuronauthors
Meffert MK,Premack BA,Schulman Hdoi
10.1016/0896-6273(94)90440-5subject
Has Abstractpub_date
1994-06-01 00:00:00pages
1235-44issue
6eissn
0896-6273issn
1097-4199pii
0896-6273(94)90440-5journal_volume
12pub_type
杂志文章相关文献
NEURON文献大全abstract：:In this issue of Neuron, Royal et al. (2018) find that a mutant form of the TRESK ion channel linked to migraine undergoes alternative translation to produce an inhibitory protein that blocks TREK channels, leading to neuronal hyperexcitability and migraine in rodents. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.12.034
更新日期：2019-01-16 00:00:00
abstract：:The developing retina generates spontaneous glutamatergic (stage III) waves of activity that sequentially recruit neighboring ganglion cells with opposite light responses (ON and OFF RGCs). This activity pattern is thought to help establish parallel ON and OFF pathways in downstream visual areas. The circuits that pro...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.05.012
更新日期：2013-07-24 00:00:00
abstract：:Intracortical somatosensory interfaces have now entered the clinical domain. Darie et al. explore the implications of research published in Science Translational Medicine by Flesher et al. (2016), discuss how to design such a system given current technology, and question how to effectively communicate with users about...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2017.02.008
更新日期：2017-02-22 00:00:00
abstract：:Conditioned place preference (CPP) is a widely used model of addiction-related behavior whose underlying mechanisms are not understood. In this study, we used dual site silicon probe recordings in freely moving mice to examine interactions between the hippocampus and nucleus accumbens in cocaine CPP. We found that CPP...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.04.015
更新日期：2018-06-06 00:00:00
abstract：:Structure-function studies have identified key functional motifs in the acetylcholine receptor, including residues that contribute to the ion channel and to the ligand-binding sites. Little is known, however, about determinants of channel gating kinetics. To identify structural correlates of gating, we examined the st...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90424-3
更新日期：1994-12-01 00:00:00
abstract：:Grid cells, border cells, head-directions cells, and conjunctive correlates found in the Medial Entorhinal Cortex (MEC) indicate the presence of highly specialized neural circuits that process allocentric space. New technical advancements, as described by Tang et al. (2014) in this issue, offer an integrated approach ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2014.12.013
更新日期：2014-12-17 00:00:00
abstract：:Using primary cultures and immortalized multipotential stem cell lines derived from wild-type and Mash1 mutant neural crest cells, we have analyzed the cellular function of MASH1 in autonomic neurogenesis. We present evidence for the existence of a precursor expressing MASH1 and neuronal markers such as neurofilament,...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90005-5
更新日期：1995-12-01 00:00:00
abstract：:The apical tuft of layer 5 pyramidal neurons is innervated by a large number of inhibitory inputs with unknown functions. Here, we studied the functional consequences and underlying molecular mechanisms of apical inhibition on dendritic spike activity. Extracellular stimulation of layer 1, during blockade of glutamate...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.04.019
更新日期：2006-05-18 00:00:00
abstract：:Memories are about the past, but they serve the future. Memory research often emphasizes the former aspect: focusing on the functions that re-constitute (re-member) experience and elucidating the various types of memories and their interrelations, timescales, and neural bases. Here we highlight the prospective nature ...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2019.08.030
更新日期：2019-10-09 00:00:00
abstract：:Primates can learn to recognize a virtually limitless number of visual objects. A candidate neural substrate for this adult plasticity is the inferior temporal cortex (ITC). Using a large stimulus set, we explored the impact that long-term experience has on the response properties of two classes of neurons in ITC: bro...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.01.032
更新日期：2012-04-12 00:00:00
abstract：:People are embedded in social interaction that shapes their brains throughout lifetime. Instead of emerging from lower-level cognitive functions, social interaction could be the default mode via which humans communicate with their environment. Should this hypothesis be true, it would have profound implications on how ...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2015.09.022
更新日期：2015-10-07 00:00:00
abstract：:The behavioral expression of fear ranges from active, cognitive responses to passive, freezing-like reactions. In this issue of Neuron, Gozzi, Jain, and colleagues suggest that neurons in the central amygdala orchestrate output signals toward either the brainstem or cholinergic basal forebrain and thereby can shift fe...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2010.08.009
更新日期：2010-08-26 00:00:00
abstract：:The product of the Wnt-1 proto-oncogene is a secreted glycoprotein that is normally produced in regions of the embryonic neural tube. We show here that expression of mouse Wnt-1 cDNA in the rat PC12 pheochromocytoma cell line causes a dramatic conversion from a round to a flat cell morphology. In addition, PC12 cells ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90116-9
更新日期：1993-11-01 00:00:00
abstract：:In the developing nervous system, neurons are generated at sites distant from their ultimate location. In the vertebrate CNS, neurons utilize distinct migration strategies to reach their ultimate residence. This review discusses the contribution of tangential migration to the architectural development of the cerebral ...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(01)00370-1
更新日期：2001-08-02 00:00:00
abstract：:In recent years, nerve growth factor (NGF) has gained attention as a potential therapeutic agent for Alzheimer's disease (AD). To study the expression of NGF and its homologs, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3), postmortem samples of hippocampus from AD and control donors were examined ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(91)90273-3
更新日期：1991-11-01 00:00:00
abstract：:Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by mutations in MECP2, a nuclear protein that becomes phosphorylated at S421 in response to neuronal activation. We show here that disruption of MeCP2 S421 phosph...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.08.022
更新日期：2011-10-06 00:00:00
abstract：:We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR5(2b,) GluR5(2c), and GluR6. Of these, we show that both GRIP and PICK1 interactions are required to maintain KAR-mediated synaptic function at mossy fiber-CA3 synapses. In a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)01191-1
更新日期：2003-02-20 00:00:00
abstract：:The auditory cortex encodes information about sounds through the combined activity of large numbers of neurons, but the way this population activity is organized has not been clear. In this issue of Neuron, Bathellier et al. (2012) show that firing in the superficial layers of auditory cortex is organized into a small...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2012.10.007
更新日期：2012-10-18 00:00:00
abstract：:Induced CREB activity is a hallmark of long-term memory, but the full repertoire of CREB transcriptional targets required specifically for memory is not known in any system. To obtain a more complete picture of the mechanisms involved in memory, we combined memory training with genome-wide transcriptional analysis of ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.12.029
更新日期：2015-01-21 00:00:00
abstract：:The debate over the nature of mechanisms leading to the establishment of synaptic specificity has engaged neuroscientists for the best part of a century. In this issue of Neuron, Balaskas et al. (2019) provide new evidence in favor of the role of positional strategies in the organization of sensory-motor circuits. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2019.05.046
更新日期：2019-06-19 00:00:00
abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synaptic plasticity and memory formation. Although significant progress has been made in understanding the role of postsynaptic CaMKII in synaptic plasticity, very little is known about its presynaptic functio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(04)00143-6
更新日期：2004-04-08 00:00:00
abstract：:The frontline anti-malarial drug artemisinin and its derivatives have also been implicated in modulating multiple mammalian cellular pathways, including the recent identification of targeting γ-aminobutyric acid type A receptor (GABAAR) signaling in the pancreas. Their molecular mechanism of action, however, remains e...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.01.001
更新日期：2019-02-20 00:00:00
abstract：:In this issue of Neuron, Costa et al. (2017) introduce a theoretical framework that predicts the ratio of presynaptic and postsynaptic changes taking place during LTP and LTD and show that these processes co-operate so as to optimize the postsynaptic response statistics. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.09.022
更新日期：2017-09-27 00:00:00
abstract：:The paraventricular nucleus of the thalamus (PVT) is thought to regulate behavioral responses under emotionally arousing conditions. Reward-associated cues activate PVT neurons; however, the specific PVT efferents regulating reward seeking remain elusive. Using a cued sucrose-seeking task, we manipulated PVT activity ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.03.036
更新日期：2017-04-19 00:00:00
abstract：:The structural basis for the synthesis of specific proteins within distinct intraneuronal compartments is unknown. We studied the distribution of poly(A) mRNA within cultured cerebrocortical neurons using high resolution in situ hybridization to identify cytoskeletal components that may anchor mRNA. After 1 day in cul...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90213-5
更新日期：1994-03-01 00:00:00
abstract：:We have investigated ubiquitinated paired helical filaments, which produce a proteinaceous smear in SDS-polyacrylamide gel electrophoresis and immunoblotting. The smear consisted largely of the carboxy-terminal portion of tau and ubiquitin. The ubiquitin-targeted protein was identified as tau in paired helical filamen...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90063-w
更新日期：1993-06-01 00:00:00
abstract：:Self-consciousness has mostly been approached by philosophical enquiry and not by empirical neuroscientific study, leading to an overabundance of diverging theories and an absence of data-driven theories. Using robotic technology, we achieved specific bodily conflicts and induced predictable changes in a fundamental a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.03.009
更新日期：2011-04-28 00:00:00
abstract：:Neurons propagate information through circuits by integrating thousands of synaptic inputs to generate an action potential output. Inputs from different origins are often targeted to distinct regions of a neuron's dendritic tree, with synapses on more distal dendrites normally having a weaker influence on cellular out...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.04.013
更新日期：2010-05-27 00:00:00
abstract：:Phosphatidylinositol 3-kinase (PI3K)-dependent phosphoinositide signaling has been implicated in diverse cellular systems coupled to receptors for many different ligands, but the extent to which it functions in sensory transduction is yet to be determined. We now report that blocking PI3K activity increases odorant-ev...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00610-4
更新日期：2002-02-28 00:00:00
abstract：:Mutations in a synaptic organizing pathway contribute to autism. Autism-associated mutations in MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) are thought to reduce excitatory/inhibitory transmission. However, we show that mutation of Mdga2 elevates excitatory transmission, and that MDGA2 blocks n...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.08.016
更新日期：2016-09-07 00:00:00
