Cell assemblies of the superficial cortex.

abstract：:Synaptic plasticity during critical periods of development requires intact inhibitory circuitry. We report that subplate neurons are needed both for maturation of inhibition and for the proper sign of ocular dominance (OD) plasticity. Removal of subplate neurons prevents the developmental upregulation of genes involve...

journal_title：Neuron

authors： Kanold PO,Shatz CJ

更新日期：2006-09-07 00:00:00

abstract：:In this issue of Neuron, Oh and Gu (2013) present a model in which intimately related embryonic nerves and blood vessels are patterned independently in response to different guidance cues from a central organizer: the whisker. ...

journal_title：Neuron

authors： Chauvet S,Mann F

更新日期：2013-10-16 00:00:00

abstract：:In the developing nervous system, neurons are generated at sites distant from their ultimate location. In the vertebrate CNS, neurons utilize distinct migration strategies to reach their ultimate residence. This review discusses the contribution of tangential migration to the architectural development of the cerebral ...

journal_title：Neuron

authors： Maricich SM,Gilmore EC,Herrup K

更新日期：2001-08-02 00:00:00

abstract：:Expression of aversive memories is key for survival, but the underlying brain mechanisms are not fully understood. Medial habenular (MHb) axons corelease glutamate and acetylcholine onto target postsynaptic interpeduncular (IPN) neurons, but their role in aversive memories has not been addressed so far. We found that ...

journal_title：Neuron

authors： Soria-Gómez E,Busquets-Garcia A,Hu F,Mehidi A,Cannich A,Roux L,Louit I,Alonso L,Wiesner T,Georges F,Verrier D,Vincent P,Ferreira G,Luo M,Marsicano G

更新日期：2015-10-21 00:00:00

abstract：:Several molecules involved in the development of the nervous system have specific binding sites for the glycosaminoglycan (GAG) side chains of proteoglycans. Exogenous GAGs should bind to these sites, competitively inhibit interactions with proteoglycans, and perturb development. GAGs added to the culture medium pertu...

journal_title：Neuron

authors： Wang L,Denburg JL

更新日期：1992-04-01 00:00:00

abstract：:Previous research suggests that synchronous neural activity underlies perceptual grouping of visual image features. The generality of this mechanism is unclear, however, as previous studies have focused on pairs of neurons with overlapping or collinear receptive fields. By sampling more broadly and employing stimuli t...

journal_title：Neuron

authors： Palanca BJ,DeAngelis GC

更新日期：2005-04-21 00:00:00

abstract：:Cortical plasticity is thought to be important for the establishment, consolidation, and retrieval of permanent memory. Hippocampal long-term potentiation (LTP), a cellular mechanism of learning and memory, requires the activation of glutamate N-methyl-D-aspartate (NMDA) receptors. In particular, it has been suggested...

journal_title：Neuron

authors： Zhao MG,Toyoda H,Lee YS,Wu LJ,Ko SW,Zhang XH,Jia Y,Shum F,Xu H,Li BM,Kaang BK,Zhuo M

更新日期：2005-09-15 00:00:00

abstract：:Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is a heritable trait. Working memory deficits are characteristic for many psychiatric disorders. We performed genome-wide gene set enrichment analyses in multiple independent data sets of young and aged cognitively ...

journal_title：Neuron

authors： Heck A,Fastenrath M,Ackermann S,Auschra B,Bickel H,Coynel D,Gschwind L,Jessen F,Kaduszkiewicz H,Maier W,Milnik A,Pentzek M,Riedel-Heller SG,Ripke S,Spalek K,Sullivan P,Vogler C,Wagner M,Weyerer S,Wolfsgruber S,de

更新日期：2014-03-05 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) is a potent regulator of oligodendrocyte development and myelination in vitro, but its effect on myelination in vivo has never been tested directly. Therefore, we examined brain growth and myelination in a transgenic mouse line that overexpresses IGF-I. By postnatal day 55, when br...

journal_title：Neuron

authors： Carson MJ,Behringer RR,Brinster RL,McMorris FA

更新日期：1993-04-01 00:00:00

abstract：:Antibodies were raised to three portions of the predicted sequences of Shaker, a gene that encodes a family of K+ channel components that are produced by the alternative splicing of transcripts. On immunoblots, the protein products appear to be 65,000-85,000 daltons in size. No smaller products were detected. Immunocy...

journal_title：Neuron

authors： Schwarz TL,Papazian DM,Carretto RC,Jan YN,Jan LY

更新日期：1990-01-01 00:00:00

abstract：:The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a network structure composed of multiple types of neurons. Here, we report that mice with a Bmal1 deletion specific to arginine vasopressin (AVP)-producing neurons showed marked lengthening in the free-running period and activity time of...

journal_title：Neuron

authors： Mieda M,Ono D,Hasegawa E,Okamoto H,Honma K,Honma S,Sakurai T

更新日期：2015-03-04 00:00:00

abstract：:The p75 neurotrophin receptor (p75(NTR)) is involved in numerous neuronal signaling paths but its fundamental signaling mechanisms are unknown. In this issue of Neuron, Vilar et al. show that p75NTR functions as a covalently crosslinked dimer to transduce NGF-induced signaling events. ...

journal_title：Neuron

authors： Barker PA

更新日期：2009-04-16 00:00:00

abstract：:Interactions between genetic and epigenetic effects shape brain function, behavior, and the risk for mental illness. Random X inactivation and genomic imprinting are epigenetic allelic effects that are well known to influence genetic architecture and disease risk. Less is known about the nature, prevalence, and conser...

journal_title：Neuron

authors： Huang WC,Ferris E,Cheng T,Hörndli CS,Gleason K,Tamminga C,Wagner JD,Boucher KM,Christian JL,Gregg C

更新日期：2017-03-08 00:00:00

abstract：:Gene transcription is the process by which the genetic codes of organisms are read and interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As cells function in their respective niches, transcription further allows mature cells to interact dynamically with their external enviro...

journal_title：Neuron

authors： Yap EL,Greenberg ME

更新日期：2018-10-24 00:00:00

abstract：:Brain areas in the frontal lobe have been implicated in behavioral flexibility and control. The study by Johnston et al. in this issue of Neuron provides novel insights into the roles of the prefrontal and anterior cingulate cortices in controlling behavior. ...

journal_title：Neuron

authors： Rainer G

更新日期：2007-02-01 00:00:00

abstract：:In stable environments, decision makers can exploit their previously learned strategies for optimal outcomes, while exploration might lead to better options in unstable environments. Here, to investigate the cortical contributions to exploratory behavior, we analyzed single-neuron activity recorded from four different...

journal_title：Neuron

authors： Donahue CH,Seo H,Lee D

更新日期：2013-10-02 00:00:00

abstract：:Neurodegenerative diseases have been intensively studied, but a comprehensive understanding of their pathogenesis remains elusive. An increasing body of evidence suggests that non-cell-autonomous processes play critical roles during the initiation and spatiotemporal progression or propagation of the dominant pathology...

journal_title：Neuron

authors： Garden GA,La Spada AR

更新日期：2012-03-08 00:00:00

abstract：:Biochemical studies suggest that syntaxin 1A participates in multiple protein-protein interactions in the synaptic terminal, but the in vivo significance of these interactions is poorly understood. We used a targeted mutagenesis approach to eliminate specific syntaxin binding interactions and demonstrate that Drosophi...

journal_title：Neuron

authors： Wu MN,Fergestad T,Lloyd TE,He Y,Broadie K,Bellen HJ

更新日期：1999-07-01 00:00:00

abstract：:Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation and mechanotransduction have remained functionally undefined. Here we report our find...

journal_title：Neuron

authors： Zhao Q,Wu K,Geng J,Chi S,Wang Y,Zhi P,Zhang M,Xiao B

更新日期：2016-03-16 00:00:00

abstract：:Given that cocaine induces neuroadaptations through regulation of gene expression, we investigated whether chromatin remodeling at specific gene promoters may be a key mechanism. We show that cocaine induces specific histone modifications at different gene promoters in striatum, a major neural substrate for cocaine's ...

journal_title：Neuron

authors： Kumar A,Choi KH,Renthal W,Tsankova NM,Theobald DE,Truong HT,Russo SJ,Laplant Q,Sasaki TS,Whistler KN,Neve RL,Self DW,Nestler EJ

更新日期：2005-10-20 00:00:00

abstract：:In this issue of Neuron, a study by Baumgartner et al. investigates the influence of oxytocin on trust behavior and its neural mechanisms. The authors report that, following breaches of trust, oxytocin facilitates prosocial behavior while modulating neural signals in the amygdala and caudate nucleus. The findings have...

journal_title：Neuron

authors： Delgado MR

更新日期：2008-05-22 00:00:00

abstract：:S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group on the target protein. Under physiological conditions, S-nitrosylation can be an important modulator of signal transduction pathways,...

journal_title：Neuron

authors： Nakamura T,Tu S,Akhtar MW,Sunico CR,Okamoto S,Lipton SA

更新日期：2013-05-22 00:00:00

abstract：:In cerebellar Purkinje cell dendrites, heterosynaptic calcium signaling induced by the proximal climbing fiber (CF) input controls plasticity at distal parallel fiber (PF) synapses. The substrate and regulation of this long-range dendritic calcium signaling are poorly understood. Using high-speed calcium imaging, we e...

journal_title：Neuron

authors： Otsu Y,Marcaggi P,Feltz A,Isope P,Kollo M,Nusser Z,Mathieu B,Kano M,Tsujita M,Sakimura K,Dieudonné S

更新日期：2014-10-01 00:00:00

abstract：:A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3...

journal_title：Neuron

authors： Zhang Y,Narayan S,Geiman E,Lanuza GM,Velasquez T,Shanks B,Akay T,Dyck J,Pearson K,Gosgnach S,Fan CM,Goulding M

更新日期：2008-10-09 00:00:00

abstract：:Immunophilins, including FK506-binding proteins (FKBPs), are protein chaperones with peptidyl-prolyl isomerase (PPIase) activity. Initially identified as pharmacological receptors for immunosuppressants to regulate immune responses via isomerase-independent mechanisms, FKBPs are most highly expressed in the nervous sy...

journal_title：Neuron

authors： Shim S,Yuan JP,Kim JY,Zeng W,Huang G,Milshteyn A,Kern D,Muallem S,Ming GL,Worley PF

更新日期：2009-11-25 00:00:00

abstract：:The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have been numerous studies attempting to elucidate the underlying mechanism for this increased risk, how apoE4 influences AD onset and progression has yet to be proven. However, prevailing evide...

journal_title：Neuron

authors： Kim J,Basak JM,Holtzman DM

更新日期：2009-08-13 00:00:00

abstract：:Local neuronal networks that are responsible for walking are poorly characterized in mammals. Using an innovative approach to identify interneuron inputs onto motorneuron populations in a neonatal rodent spinal cord preparation, we have investigated the network responsible for left-right coordination of the hindlimbs....

journal_title：Neuron

authors： Butt SJ,Kiehn O

更新日期：2003-06-19 00:00:00

abstract：:Postlingually deaf subjects learn the meaning of sounds after cochlear implantation by forming new associations between sounds and their sources. Implants generate coarse frequency responses, preventing place-coding fine enough to discriminate sounds with similar temporal characteristics, e.g., buck/duck. This limitat...

journal_title：Neuron

authors： Giraud AL,Price CJ,Graham JM,Truy E,Frackowiak RS

更新日期：2001-06-01 00:00:00

abstract：:Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...

journal_title：Neuron

authors： Quinlan EM,Lebel D,Brosh I,Barkai E

更新日期：2004-01-22 00:00:00

abstract：:Vesicular transporters are required for the storage of all classical and amino acid neurotransmitters in synaptic vesicles. Some neurons lack known vesicular transporters, suggesting additional neurotransmitter systems remain unidentified. Insect mushroom bodies (MBs) are critical for several behaviors, including lear...

journal_title：Neuron

authors： Brooks ES,Greer CL,Romero-Calderón R,Serway CN,Grygoruk A,Haimovitz JM,Nguyen BT,Najibi R,Tabone CJ,de Belle JS,Krantz DE

更新日期：2011-10-20 00:00:00