Abstract：
:The hippocampus is essential for spatiotemporal cognition. Sequences of neuronal activation provide a substrate for this fundamental function. At the behavioral timescale, these sequences have been shown to occur either in the presence of successive external landmarks or through internal mechanisms within an episodic memory task. In both cases, activity is externally constrained by the organization of the task and by the size of the environment explored. Therefore, it remains unknown whether hippocampal activity can self-organize into a default mode in the absence of any external memory demand or spatiotemporal boundary. Here we show that, in the presence of self-motion cues, a population code integrating distance naturally emerges in the hippocampus in the form of recurring sequences. These internal dynamics clamp spontaneous travel since run distance distributes into integer multiples of the span of these sequences. These sequences may thus guide navigation when external landmarks are reduced.
journal_name
Neuronjournal_title
Neuronauthors
Villette V,Malvache A,Tressard T,Dupuy N,Cossart Rdoi
10.1016/j.neuron.2015.09.052subject
Has Abstractpub_date
2015-10-21 00:00:00pages
357-66issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00841-7journal_volume
88pub_type
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