A Circuit for Integration of Head- and Visual-Motion Signals in Layer 6 of Mouse Primary Visual Cortex.

Abstract:

:To interpret visual-motion events, the underlying computation must involve internal reference to the motion status of the observer's head. We show here that layer 6 (L6) principal neurons in mouse primary visual cortex (V1) receive a diffuse, vestibular-mediated synaptic input that signals the angular velocity of horizontal rotation. Behavioral and theoretical experiments indicate that these inputs, distributed over a network of 100 L6 neurons, provide both a reliable estimate and, therefore, physiological separation of head-velocity signals. During head rotation in the presence of visual stimuli, L6 neurons exhibit postsynaptic responses that approximate the arithmetic sum of the vestibular and visual-motion response. Functional input mapping reveals that these internal motion signals arrive into L6 via a direct projection from the retrosplenial cortex. We therefore propose that visual-motion processing in V1 L6 is multisensory and contextually dependent on the motion status of the animal's head.

journal_name

Neuron

journal_title

Neuron

authors

Vélez-Fort M,Bracey EF,Keshavarzi S,Rousseau CV,Cossell L,Lenzi SC,Strom M,Margrie TW

doi

10.1016/j.neuron.2018.02.023

subject

Has Abstract

pub_date

2018-04-04 00:00:00

pages

179-191.e6

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(18)30144-2

journal_volume

98

pub_type

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