Abstract：
:Cytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal, ongoing signaling between cells of nonimmune tissues, including the nervous system. As a consequence of this dual role, cytokines induced in response to maternal infection or prenatal hypoxia can profoundly impact fetal neurodevelopment. The neurodevelopmental roles of individual cytokine signaling pathways are being elucidated through gain- and loss-of-function studies in cell culture and model organisms. We review this work with a particular emphasis on studies where cytokines, their receptors, or components of their signaling pathways have been altered in vivo. The extensive and diverse requirements for properly regulated cytokine signaling during normal nervous system development revealed by these studies sets the foundation for ongoing and future work aimed at understanding how cytokines induced normally and pathologically during critical stages of fetal development alter nervous system function and behavior later in life.
journal_name
Neuronjournal_title
Neuronauthors
Deverman BE,Patterson PHdoi
10.1016/j.neuron.2009.09.002subject
Has Abstractpub_date
2009-10-15 00:00:00pages
61-78issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(09)00680-1journal_volume
64pub_type
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