当前位置： SCI文献检索 > NEURON期刊下所有文献 > Gq alpha protein function in vivo: genetic dissection of its role in photoreceptor cell physiology.

Gq alpha protein function in vivo: genetic dissection of its role in photoreceptor cell physiology.

Abstract：

:Heterotrimeric G proteins mediate a variety of signaling processes by coupling seven-transmembrane receptors to intracellular effector molecules. The Drosophila phototransduction cascade is a G protein-coupled signaling cascade that utilizes a phospholipase C (PLC beta) effector. PLC beta has been shown to be activated by Gq alpha in reconstituted systems. To determine whether a Gq-like protein couples rhodopsin to PLC, and to study its function, we isolated a mutant defective in a photoreceptor-specific Gq protein, DGq. We now demonstrate that Gq is essential for the activation of the phototransduction cascade in vivo. We also generated transgenic flies expressing DGq under an inducible promoter and show that it is possible to manipulate the sensitivity of a photoreceptor cell by controlled expression of DGq. Characterization of quantum bumps in mutants expressing less that 1% of the levels of DGq revealed that the rhodopsin-G protein interaction does not determine the gain of the single photon responses. Together, these results provide significant insight into the role of Gq in regulating the output of a photoreceptor cell.

journal_name

Neuron

journal_title

Neuron

authors

Scott K,Becker A,Sun Y,Hardy R,Zuker C

doi

10.1016/0896-6273(95)90182-5

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

919-27

issue

4

eissn

0896-6273

issn

1097-4199

pii

0896-6273(95)90182-5

journal_volume

15

pub_type

杂志文章

相关文献

NEURON文献大全
  • Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex.

    abstract：:Recent advances in brain imaging techniques, including functional magnetic resonance imaging (fMRI), offer great promise for noninvasive mapping of brain function. However, the indirect nature of the imaging signals to the underlying neural activity limits the interpretation of the resulting maps. The present report r...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(03)00403-3

    authors： Devor A,Dunn AK,Andermann ML,Ulbert I,Boas DA,Dale AM

    更新日期：2003-07-17 00:00:00

  • A reentrant loop domain in the glutamate carrier EAAT1 participates in substrate binding and translocation.

    abstract：:To investigate the structural determinants underlying transport by the glutamate transporter EAAT1, we mutated each of 24 highly conserved residues (P392 to Q415) to cysteine. A majority of these substituted cysteines react with the sulfhydryl-modifying reagent MTSEA, suggesting that they reside in an aqueous environm...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(00)80666-2

    authors： Seal RP,Amara SG

    更新日期：1998-12-01 00:00:00

  • Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility.

    abstract：:The mechanisms through which estrogen regulates gonadotropin-releasing hormone (GnRH) neurons to control mammalian ovulation are unknown. We found that estrogen positive feedback to generate the preovulatory gonadotropin surge was normal in estrogen receptor beta knockout (ERbeta) mutant mice, but absent in ERalpha mu...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2006.07.023

    authors： Wintermantel TM,Campbell RE,Porteous R,Bock D,Gröne HJ,Todman MG,Korach KS,Greiner E,Pérez CA,Schütz G,Herbison AE

    更新日期：2006-10-19 00:00:00

  • Cascaded effects of spatial adaptation in the early visual system.

    abstract：:Virtually all stages of the visual system exhibit adaptation: neurons adjust their responses based on the recent stimulus history. While some of these adjustments occur at specific stages, others may be inherited from earlier stages. How do adaptation effects cascade along the visual system? We measured spatially sele...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2013.11.025

    authors： Dhruv NT,Carandini M

    更新日期：2014-02-05 00:00:00

  • Activation of light-dependent K+ channels in ciliary invertebrate photoreceptors involves cGMP but not the IP3/Ca2+ cascade.

    abstract：:The activation of light-dependent K+ channels in ciliary photoreceptors from Pecten was investigated using intracellular dialysis of putative messengers and modulators. Neither elevated [Ca2+] nor BAPTA changed the membrane current in the dark or the light response. IP3 and the antagonists heparin and decavanadate wer...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(95)90149-3

    authors： del Pilar Gomez M,Nasi E

    更新日期：1995-09-01 00:00:00

  • Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins.

    abstract：:Binding between DIP and Dpr neuronal recognition proteins has been proposed to regulate synaptic connections between lamina and medulla neurons in the Drosophila visual system. Each lamina neuron was previously shown to express many Dprs. Here, we demonstrate, by contrast, that their synaptic partners typically expres...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2018.10.046

    authors： Cosmanescu F,Katsamba PS,Sergeeva AP,Ahlsen G,Patel SD,Brewer JJ,Tan L,Xu S,Xiao Q,Nagarkar-Jaiswal S,Nern A,Bellen HJ,Zipursky SL,Honig B,Shapiro L

    更新日期：2018-12-19 00:00:00

  • Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology.

    abstract：:In this issue of Neuron, Chakrabarty et al. (2015) and Guillot-Sestier et al. (2015) reveal that the anti-inflammatory cytokine IL-10 inhibits Aβ clearance by microglia, worsening cognitive decline in mouse models of Alzheimer's disease (AD). These studies provide further support that pro-inflammatory signaling is an ...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2015.01.021

    authors： Michaud JP,Rivest S

    更新日期：2015-02-04 00:00:00

  • Top-down coordination of local cortical state during selective attention.

    abstract：:Spontaneous fluctuations in cortical excitability influence sensory processing and behavior. These fluctuations, long thought to reflect global changes in cortical state, were recently found to be modulated locally within a retinotopic map during spatially selective attention. We report that periods of vigorous (On) a...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2020.12.013

    authors： van Kempen J,Gieselmann MA,Boyd M,Steinmetz NA,Moore T,Engel TA,Thiele A

    更新日期：2020-12-30 00:00:00

  • Agonist-activated cobalt uptake identifies divalent cation-permeable kainate receptors on neurons and glial cells.

    abstract：:Activation of kainate receptors causes Co2+ influx into neurons, type-2 astrocytes, and O-2A progenitor cells. Agonist-activated Co2+ uptake can be performed using cultured cells or fresh tissue slices. Based on the pattern of response to kainate, glutamate, and quisqualate, three functionally different kainate-activa...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(91)90302-g

    authors： Pruss RM,Akeson RL,Racke MM,Wilburn JL

    更新日期：1991-09-01 00:00:00

  • Oscillatory substrates of fear and safety.

    abstract：:Oscillatory activity in the basolateral amygdala (BLA) is critical for emotional behavior. In this issue of Neuron, Stujenske et al. (2014) describe novel dynamics of BLA theta-gamma-coupled neuronal oscillations associated with conditioned and innate fear. ...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2014.08.014

    authors： Bocchio M,Capogna M

    更新日期：2014-08-20 00:00:00

  • Intracellular calcium regulates the survival of early sensory neurons before they become dependent on neurotrophic factors.

    abstract：:To investigate the role of intracellular Ca2+ in the survival of developing neurons before they become neurotrophic factor dependent, we have studied chick embryo nodose neurons, which have a particularly protracted period of neuorophic factor independence. Pharmacological reduction of intracellular free Ca2+ or deple...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(92)90193-h

    authors： Larmet Y,Dolphin AC,Davies AM

    更新日期：1992-09-01 00:00:00

  • Neuronal Inhibition under the Spotlight.

    abstract：:In this issue of Neuron,Lin et al. (2015) report an optical method to precisely manipulate the activity of GABAA receptors by designing a mutant receptor that binds photosensitive compounds. This allows for studying GABAA receptors in situ and represents a valuable tool to investigate how inhibition affects brain phys...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2015.11.014

    authors： Mortensen M,Smart TG

    更新日期：2015-12-02 00:00:00

  • Reconstructing voltage sensor-pore interaction from a fluorescence scan of a voltage-gated K+ channel.

    abstract：:X-ray crystallography has made considerable recent progress in providing static structures of ion channels. Here we describe a complementary method-systematic fluorescence scanning-that reveals the structural dynamics of a channel. Local protein motion was measured from changes in the fluorescent intensity of a fluoro...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(00)00068-4

    authors： Gandhi CS,Loots E,Isacoff EY

    更新日期：2000-09-01 00:00:00

  • Initiation and spread of sodium action potentials in cerebellar Purkinje cells.

    abstract：:Simultaneous whole-cell recordings were made from the soma and dendrites of cerebellar Purkinje cells in rat brain slices. Sodium action potentials, evoked by either depolarizing current pulses or synaptic stimulation of parallel or climbing fibers, always occurred first at the soma and decreased in amplitude with inc...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(94)90037-x

    authors： Stuart G,Häusser M

    更新日期：1994-09-01 00:00:00

  • Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.

    abstract：:The earliest stages of Alzheimer's disease (AD) are characterized by the formation of mature tangles in the entorhinal cortex and disorientation and confusion when navigating familiar places. The medial entorhinal cortex (MEC) contains specialized neurons called grid cells that form part of the spatial navigation syst...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2016.12.023

    authors： Fu H,Rodriguez GA,Herman M,Emrani S,Nahmani E,Barrett G,Figueroa HY,Goldberg E,Hussaini SA,Duff KE

    更新日期：2017-02-08 00:00:00

  • Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B/Akt phosphorylation of NR2C.

    abstract：:NMDA receptor subunit composition varies throughout the brain, providing molecular diversity in NMDA receptor function. The NR2 subunits (NR2A-D) in large part dictate the distinct functional properties of NMDA receptors and differentially regulate receptor trafficking. Although the NR2C subunit is highly enriched in ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2009.04.015

    authors： Chen BS,Roche KW

    更新日期：2009-05-28 00:00:00

  • Functional assembly of accessory optic system circuitry critical for compensatory eye movements.

    abstract：:Accurate motion detection requires neural circuitry that compensates for global visual field motion. Select subtypes of retinal ganglion cells perceive image motion and connect to the accessory optic system (AOS) in the brain, which generates compensatory eye movements that stabilize images during slow visual field mo...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2015.03.064

    authors： Sun LO,Brady CM,Cahill H,Al-Khindi T,Sakuta H,Dhande OS,Noda M,Huberman AD,Nathans J,Kolodkin AL

    更新日期：2015-05-20 00:00:00

  • The headache of a hyperactive calcium channel.

    abstract：:Migraine is thought to be triggered by excessive neocortical neuronal excitability that leads to cortical spreading depression. In this issue of Neuron, Tottene et al. study a mouse model of familial hemiplegic migraine type 1, and provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical gl...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2009.02.015

    authors： Xue M,Rosenmund C

    更新日期：2009-03-12 00:00:00

  • TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.

    abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the P362L mutation in the low-complexity domain (LCD) of T cell-rest...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2017.07.025

    authors： Mackenzie IR,Nicholson AM,Sarkar M,Messing J,Purice MD,Pottier C,Annu K,Baker M,Perkerson RB,Kurti A,Matchett BJ,Mittag T,Temirov J,Hsiung GR,Krieger C,Murray ME,Kato M,Fryer JD,Petrucelli L,Zinman L,Weintraub S,

    更新日期：2017-08-16 00:00:00

  • Calcium signaling in dendrites and spines: practical and functional considerations.

    abstract：:Changes in intracellular calcium (Ca) concentration following synaptic and suprathreshold activity are mediated by a wide range of sources and contribute to the regulation of myriad neuronal functions. The development of Ca imaging techniques has dramatically increased our understanding of the complex interactions bet...

    journal_title：Neuron

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuron.2008.08.020

    authors： Higley MJ,Sabatini BL

    更新日期：2008-09-25 00:00:00

  • Imaging Exocytosis of Single Synaptic Vesicles at a Fast CNS Presynaptic Terminal.

    abstract：:Synaptic vesicles are tethered to the active zone where they are docked/primed so that they can fuse rapidly upon Ca(2+) influx. To directly study these steps at a CNS presynaptic terminal, we used total internal reflection fluorescence (TIRF) microscopy at the live isolated calyx of Held terminal and measured the mov...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2015.09.047

    authors： Midorikawa M,Sakaba T

    更新日期：2015-11-04 00:00:00

  • Australian Brain Alliance.

    abstract：:A proposal for an Australian Brain Initiative (ABI) is under development by members of the Australian Brain Alliance. Here we discuss the goals of the ABI, its areas of research focus, its context in the Australian research setting, and its necessity for ensuring continued success for Australian brain research. ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2016.10.038

    authors： Australian Brain Alliance Steering Committee.

    更新日期：2016-11-02 00:00:00

  • Making an effort to listen: mechanical amplification in the ear.

    abstract：:The inner ear's performance is greatly enhanced by an active process defined by four features: amplification, frequency selectivity, compressive nonlinearity, and spontaneous otoacoustic emission. These characteristics emerge naturally if the mechanoelectrical transduction process operates near a dynamical instability...

    journal_title：Neuron

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuron.2008.07.012

    authors： Hudspeth AJ

    更新日期：2008-08-28 00:00:00

  • The human basal forebrain integrates the old and the new.

    abstract：:Acquisition of new learning is challenged by the phenomenon of proactive interference (PI), which occurs when previous learning disrupts later learning. Whereas human neuroimaging studies have focused on the cortical contributions to interference resolution, animal studies demonstrate that efficient resolution of PI d...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(04)00080-7

    authors： De Rosa E,Desmond JE,Anderson AK,Pfefferbaum A,Sullivan EV

    更新日期：2004-03-04 00:00:00

  • Selective replenishment of two vesicle pools depends on the source of Ca2+ at the Drosophila synapse.

    abstract：:After synaptic vesicles (SVs) undergo exocytosis, SV pools are replenished by recycling SVs at nerve terminals. At Drosophila neuromuscular synapses, there are two distinct SV pools (i.e., the exo/endo cycling pool (ECP), which primarily maintains synaptic transmission, and the reserve pool (RP), which participates in...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(02)00777-8

    authors： Kuromi H,Kidokoro Y

    更新日期：2002-07-18 00:00:00

  • Revealing Detail along the Visual Hierarchy: Neural Clustering Preserves Acuity from V1 to V4.

    abstract：:How primates perceive objects along with their detailed features remains a mystery. This ability to make fine visual discriminations depends upon a high-acuity analysis of spatial frequency (SF) along the visual hierarchy from V1 to inferotemporal cortex. By studying the transformation of SF across macaque parafoveal ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2018.03.009

    authors： Lu Y,Yin J,Chen Z,Gong H,Liu Y,Qian L,Li X,Liu R,Andolina IM,Wang W

    更新日期：2018-04-18 00:00:00

  • Task-guided selection of the dual neural pathways for reading.

    abstract：:The visual perception of words is known to activate the auditory representation of their spoken forms automatically. We examined the neural mechanism for this phonological activation using transcranial magnetic stimulation (TMS) with a masked priming paradigm. The stimulation sites (left superior temporal gyrus [L-STG...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2006.09.030

    authors： Nakamura K,Hara N,Kouider S,Takayama Y,Hanajima R,Sakai K,Ugawa Y

    更新日期：2006-11-09 00:00:00

  • Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.

    abstract：:Currently there is no general approach for achieving specific optogenetic control of genetically defined cell types in rats, which provide a powerful experimental system for numerous established neurophysiological and behavioral paradigms. To overcome this challenge we have generated genetically restricted recombinase...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2011.10.028

    authors： Witten IB,Steinberg EE,Lee SY,Davidson TJ,Zalocusky KA,Brodsky M,Yizhar O,Cho SL,Gong S,Ramakrishnan C,Stuber GD,Tye KM,Janak PH,Deisseroth K

    更新日期：2011-12-08 00:00:00

  • Segregation of tactile input features in neurons of the cuneate nucleus.

    abstract：:Our tactile perception of external objects depends on skin-object interactions. The mechanics of contact dictates the existence of fundamental spatiotemporal input features-contact initiation and cessation, slip, and rolling contact-that originate from the fact that solid objects do not interpenetrate. However, it is ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2014.07.038

    authors： Jörntell H,Bengtsson F,Geborek P,Spanne A,Terekhov AV,Hayward V

    更新日期：2014-09-17 00:00:00

  • Expression of constitutively active CaMKII in target tissue modifies presynaptic axon arbor growth.

    abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) can be regulated by synaptic activity and could therefore be involved in activity-dependent control of neuronal growth. We tested whether increased CaMKII activity in postsynaptic optic tectal neurons can modify the development of retinotectal axons in Xenopus. T...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(00)80072-0

    authors： Zou DJ,Cline HT

    更新日期：1996-03-01 00:00:00