Activation of light-dependent K+ channels in ciliary invertebrate photoreceptors involves cGMP but not the IP3/Ca2+ cascade.

abstract：:Myelin ensheathes axons to allow rapid propagation of action potentials and proper nervous system function. In the peripheral nervous system, Schwann cells (SCs) radially sort axons into a 1:1 relationship before wrapping an axonal segment to form myelin. SC myelination requires the adhesion G protein-coupled receptor...

journal_title：Neuron

authors： Petersen SC,Luo R,Liebscher I,Giera S,Jeong SJ,Mogha A,Ghidinelli M,Feltri ML,Schöneberg T,Piao X,Monk KR

更新日期：2015-02-18 00:00:00

abstract：:Historical milestones in neuroscience have come in diverse forms, ranging from the resolution of specific biological mysteries via creative experimentation to broad technological advances allowing neuroscientists to ask new kinds of questions. The continuous development of tools is driven with a special necessity by t...

journal_title：Neuron

authors： Deisseroth K,Schnitzer MJ

更新日期：2013-10-30 00:00:00

abstract：:To investigate the structural determinants underlying transport by the glutamate transporter EAAT1, we mutated each of 24 highly conserved residues (P392 to Q415) to cysteine. A majority of these substituted cysteines react with the sulfhydryl-modifying reagent MTSEA, suggesting that they reside in an aqueous environm...

journal_title：Neuron

authors： Seal RP,Amara SG

更新日期：1998-12-01 00:00:00

abstract：:Early postnatal mammals, including human babies, can perform only basic motor tasks. The acquisition of skilled behaviors occurs later, requiring anatomical changes in neural circuitry to support the development of coordinated activation or suppression of functionally related muscle groups. How this circuit reorganiza...

journal_title：Neuron

authors： Gu Z,Serradj N,Ueno M,Liang M,Li J,Baccei ML,Martin JH,Yoshida Y

更新日期：2017-05-03 00:00:00

abstract：:Using electrical acupuncture, Liu et al. show how electrical stimulation of primary somatosensory neurons at different body regions can tap into discreet autonomic circuits and, depending on the parameters, initiate either a pro- or anti-inflammatory response. ...

journal_title：Neuron

authors： Kupari J,Ernfors P

更新日期：2020-11-11 00:00:00

abstract：:The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked m...

journal_title：Neuron

authors： Xiong ZQ,McNamara JO

更新日期：2002-09-12 00:00:00

abstract：:The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we exami...

journal_title：Neuron

authors： Smith AP,Stephan KE,Rugg MD,Dolan RJ

更新日期：2006-02-16 00:00:00

abstract：:Striatal dopamine plays key roles in our normal and pathological goal-directed actions. To understand dopamine function, much attention has focused on how midbrain dopamine neurons modulate their firing patterns. However, we identify a presynaptic mechanism that triggers dopamine release directly, bypassing activity i...

journal_title：Neuron

authors： Threlfell S,Lalic T,Platt NJ,Jennings KA,Deisseroth K,Cragg SJ

更新日期：2012-07-12 00:00:00

abstract：:Memories are about the past, but they serve the future. Memory research often emphasizes the former aspect: focusing on the functions that re-constitute (re-member) experience and elucidating the various types of memories and their interrelations, timescales, and neural bases. Here we highlight the prospective nature ...

journal_title：Neuron

authors： Nobre AC,Stokes MG

更新日期：2019-10-09 00:00:00

abstract：:K(ATP) channels are large heteromultimeric complexes containing four subunits from the inwardly rectifying K+ channel family (Kir6.2) and four regulatory sulphonylurea receptor subunits from the ATP-binding cassette (ABC) transporter family (SUR1 and SUR2A/B). The molecular basis for interactions between these two unr...

journal_title：Neuron

authors： Schwappach B,Zerangue N,Jan YN,Jan LY

更新日期：2000-04-01 00:00:00

abstract：:Migraine is a common, disabling, multifactorial, episodic neurovascular disorder of unknown etiology. Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine with aura that is caused by missense mutations in the CACNA1A gene that encodes the alpha(1) subunit of neuronal Ca(v)2.1 Ca(2+) channels....

journal_title：Neuron

authors： van den Maagdenberg AM,Pietrobon D,Pizzorusso T,Kaja S,Broos LA,Cesetti T,van de Ven RC,Tottene A,van der Kaa J,Plomp JJ,Frants RR,Ferrari MD

更新日期：2004-03-04 00:00:00

abstract：:The enteric nervous system (ENS) in vertebrates is derived mainly from vagal neural crest cells that enter the foregut and colonize the entire wall of the gastrointestinal tract. Failure to completely colonize the gut results in the absence of enteric ganglia (Hirschsprung's disease). Two signaling systems mediated by...

journal_title：Neuron

authors： Barlow A,de Graaff E,Pachnis V

更新日期：2003-12-04 00:00:00

abstract：:The inner ear's performance is greatly enhanced by an active process defined by four features: amplification, frequency selectivity, compressive nonlinearity, and spontaneous otoacoustic emission. These characteristics emerge naturally if the mechanoelectrical transduction process operates near a dynamical instability...

journal_title：Neuron

authors： Hudspeth AJ

更新日期：2008-08-28 00:00:00

abstract：:LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using genetic and biochemical studies involving Lrrk loss-of-function mutants and Parkinson-related LRRK2(G2019S) gain-of-kinase function, we sh...

journal_title：Neuron

authors： Matta S,Van Kolen K,da Cunha R,van den Bogaart G,Mandemakers W,Miskiewicz K,De Bock PJ,Morais VA,Vilain S,Haddad D,Delbroek L,Swerts J,Chávez-Gutiérrez L,Esposito G,Daneels G,Karran E,Holt M,Gevaert K,Moechars DW,De

更新日期：2012-09-20 00:00:00

abstract：:While there are selective regions of occipitotemporal cortex that respond to faces, letters, and bodies, the large-scale neural organization of most object categories remains unknown. Here, we find that object representations can be differentiated along the ventral temporal cortex by their real-world size. In a functi...

journal_title：Neuron

authors： Konkle T,Oliva A

更新日期：2012-06-21 00:00:00

abstract：:Previous work has hinted that prospective and retrospective coding modes exist in hippocampus. Prospective coding is believed to reflect memory retrieval processes, whereas retrospective coding is thought to be important for memory encoding. Here, we show in rats that separate prospective and retrospective modes exist...

journal_title：Neuron

authors： Bieri KW,Bobbitt KN,Colgin LL

更新日期：2014-05-07 00:00:00

abstract：:Convergent evidence suggests that corticostriatal interactions act as a gate to select the input to working memory (WM). However, not all information in WM is relevant for behavior simultaneously. For this reason, a second "output gate" might advantageously govern which contents of WM influence behavior. Here, we test...

journal_title：Neuron

authors： Chatham CH,Frank MJ,Badre D

更新日期：2014-02-19 00:00:00

abstract：:How a single fertilized cell generates diverse neuronal populations has been a fundamental biological problem since the 19(th) century. Classical histological methods revealed that postmitotic neurons are produced in a precise temporal and spatial order from germinal cells lining the cerebral ventricles. In the 20(th)...

journal_title：Neuron

authors： Breunig JJ,Haydar TF,Rakic P

更新日期：2011-05-26 00:00:00

abstract：:Many high threshold, voltage-gated Ca2+ channels, including the dihydropyridine-sensitive class (L-type), inactivate in response not only to voltage, but also to entry of Ca2+. Despite the physiological importance of this Ca(2+)-sensitive inactivation, its molecular mechanism is understood only in broad outline. We no...

journal_title：Neuron

authors： Imredy JP,Yue DT

更新日期：1994-06-01 00:00:00

abstract：:Adolescence is often described as a period of heightened reactivity to emotions paired with reduced regulatory capacities, a combination suggested to contribute to risk-taking and susceptibility to peer influence during puberty. However, no longitudinal research has definitively linked these behavioral changes to unde...

journal_title：Neuron

authors： Pfeifer JH,Masten CL,Moore WE 3rd,Oswald TM,Mazziotta JC,Iacoboni M,Dapretto M

更新日期：2011-03-10 00:00:00

abstract：:The release of neurotransmitter-filled vesicles after action potentials occurs with discrete time courses: submillisecond phasic release that can be desynchronized by activity followed by "delayed release" that persists for tens of milliseconds. Delayed release has a well-established role in synaptic integration, but ...

journal_title：Neuron

authors： Rudolph S,Overstreet-Wadiche L,Wadiche JI

更新日期：2011-06-09 00:00:00

abstract：:Sympathetic neurons in culture die by apoptosis when deprived of nerve growth factor (NGF). We used this model of programmed cell death to study the mechanisms that mediate neuronal apoptosis. Cultured sympathetic neurons were injected with copper/zinc superoxide dismutase protein (SOD) or with an expression vector co...

journal_title：Neuron

authors： Greenlund LJ,Deckwerth TL,Johnson EM Jr

更新日期：1995-02-01 00:00:00

abstract：:Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly from the medial geniculate nucleus and indirectly from the auditory cortex. Here we show in the cortico-amygdala pathway that learned fear occludes electricall...

journal_title：Neuron

authors： Tsvetkov E,Carlezon WA,Benes FM,Kandel ER,Bolshakov VY

更新日期：2002-04-11 00:00:00

abstract：:Direct brain stimulation has diverse effects on network activity. In this issue of Neuron, Qiao et al. (2020) demonstrate a novel approach for using stimulation to characterize and modulate interactions between areas of the mood processing network. ...

journal_title：Neuron

authors： Ezzyat Y

更新日期：2020-09-09 00:00:00

abstract：:The pathways that convert neural stem cells (NSCs) into functional neurons in the adult hippocampus are tightly regulated. In this issue of Neuron, Yeh et al. (2018) demonstrate that the activity of dentate mossy cells determines the balance between quiescence and activation of NSCs. ...

journal_title：Neuron

authors： Piatti VC,Schinder AF

更新日期：2018-08-08 00:00:00

abstract：:KIBRA has recently been identified as a gene associated with human memory performance. Despite the elucidation of the role of KIBRA in several diverse processes in nonneuronal cells, the molecular function of KIBRA in neurons is unknown. We found that KIBRA directly binds to the protein interacting with C-kinase 1 (PI...

journal_title：Neuron

authors： Makuch L,Volk L,Anggono V,Johnson RC,Yu Y,Duning K,Kremerskothen J,Xia J,Takamiya K,Huganir RL

更新日期：2011-09-22 00:00:00

abstract：:We describe recent progress toward defining neuronal cell types in the mouse retina and attempt to extract lessons that may be generally useful in the mammalian brain. Achieving a comprehensive catalog of retinal cell types now appears within reach, because researchers have achieved consensus concerning two fundamenta...

journal_title：Neuron

authors： Seung HS,Sümbül U

更新日期：2014-09-17 00:00:00

abstract：:Ionic currents were recorded from Xenopus oocytes injected with RNA isolated from chick or mouse brain. Three currents were studied: a rapid tetrodotoxin-sensitive Na+ current (Ina), an early outward K+ current sensitive to 4-aminopyridine (IA), and an inward current activated by the excitatory amino acid receptor ago...

journal_title：Neuron

authors： Lotan I,Volterra A,Dash P,Siegelbaum SA,Goelet P

更新日期：1988-12-01 00:00:00

abstract：:NCAM 180 isoform null neuromuscular junctions are unable to effectively mobilize and exocytose synaptic vesicles and thus exhibit periods of total transmission failure during high-frequency repetitive stimulation. We have identified a highly conserved C-terminal (KENESKA) domain on NCAM that is required to maintain ef...

journal_title：Neuron

authors： Polo-Parada L,Plattner F,Bose C,Landmesser LT

更新日期：2005-06-16 00:00:00

abstract：:Flexible behavior in humans often requires that rapid choices be made between conflicting action plans. Although much attention has focused on prefrontal regions, little is understood about the contribution of parietal cortex under situations of response conflict. Here we show that right parietal damage associated wit...

journal_title：Neuron

authors： Coulthard EJ,Nachev P,Husain M

更新日期：2008-04-10 00:00:00