Probing Network Mechanisms of Brain Stimulation in the Mood Circuit.

abstract：:Carbon monoxide (CO) induces a long-lasting alteration in cerebellar alpha 3-Na,K-ATPase independent of [Na+] but linked to cGMP synthesis and localized to Purkinje neurons. The action of CO is absent in Purkinje neuron-deficient mice, mimicked by 8-Br-cGMP, and blocked by inhibition of PKG. Glutamate (Glu) and metabo...

journal_title：Neuron

authors： Nathanson JA,Scavone C,Scanlon C,McKee M

更新日期：1995-04-01 00:00:00

abstract：:Dopamine is essential to cognitive functions. However, despite abundant studies demonstrating that dopamine neuron activity is related to reinforcement and motivation, little is known about what signals dopamine neurons convey to promote cognitive processing. We therefore examined dopamine neuron activity in monkeys p...

journal_title：Neuron

authors： Matsumoto M,Takada M

更新日期：2013-09-04 00:00:00

abstract：:In order to deal effectively with danger, it is imperative to know about it. This is what nociceptors do--these primary sensory neurons are specialized to detect intense stimuli and represent, therefore, the first line of defense against any potentially threatening or damaging environmental inputs. By sensing noxious ...

journal_title：Neuron

authors： Woolf CJ,Ma Q

更新日期：2007-08-02 00:00:00

abstract：:Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron su...

journal_title：Neuron

authors： Lammel S,Ion DI,Roeper J,Malenka RC

更新日期：2011-06-09 00:00:00

abstract：:Modulation of evoked quantal transmitter release by protein kinase C (PKC) was investigated at an identified cholinergic neuro-neuronal synapse of the Aplysia buccal ganglion. Evoked acetylcholine release was increased by a diacylglycerol analog that activates PKC and was decreased by H-7, a blocker of PKC. FLRFamide ...

journal_title：Neuron

authors： Fossier P,Baux G,Tauc L

更新日期：1990-10-01 00:00:00

abstract：:Bcl-2 is a major regulator of programmed cell death, a critical process in shaping the developing nervous system. To assess whether Bcl-2 is involved in regulating neuronal survival and in mediating the neuroprotective action of neurotrophic factors, we generated Bcl-2-deficient mice. At birth, the number of facial mo...

journal_title：Neuron

authors： Michaelidis TM,Sendtner M,Cooper JD,Airaksinen MS,Holtmann B,Meyer M,Thoenen H

更新日期：1996-07-01 00:00:00

abstract：:Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation. Here we consider its roles in neuronal health and disease. We review evidence from mouse knockout studies demonstrating the normal functions of autophagy as a protective factor against neurodegeneration associated with...

journal_title：Neuron

authors： Menzies FM,Fleming A,Caricasole A,Bento CF,Andrews SP,Ashkenazi A,Füllgrabe J,Jackson A,Jimenez Sanchez M,Karabiyik C,Licitra F,Lopez Ramirez A,Pavel M,Puri C,Renna M,Ricketts T,Schlotawa L,Vicinanza M,Won H,Zhu Y,

更新日期：2017-03-08 00:00:00

abstract：:Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood. We show here that Notch and abl mutations interact synergistically to produce synthetic lethality and defects in axon extension. Surprisingly, we cannot...

journal_title：Neuron

authors： Giniger E

更新日期：1998-04-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) is a potent regulator of oligodendrocyte development and myelination in vitro, but its effect on myelination in vivo has never been tested directly. Therefore, we examined brain growth and myelination in a transgenic mouse line that overexpresses IGF-I. By postnatal day 55, when br...

journal_title：Neuron

authors： Carson MJ,Behringer RR,Brinster RL,McMorris FA

更新日期：1993-04-01 00:00:00

abstract：:Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excito...

journal_title：Neuron

authors： Ellerby LM

更新日期：2002-03-14 00:00:00

abstract：:The fields of neuroscience and artificial intelligence (AI) have a long and intertwined history. In more recent times, however, communication and collaboration between the two fields has become less commonplace. In this article, we argue that better understanding biological brains could play a vital role in building i...

journal_title：Neuron

authors： Hassabis D,Kumaran D,Summerfield C,Botvinick M

更新日期：2017-07-19 00:00:00

abstract：:A circadian clock regulates a number of diverse physiological functions in the vertebrate eye. In this study, we show that mRNA for the red-sensitive cone pigment, iodopsin, fluctuates with a circadian rhythm in chicken retina. Transcript levels increase in the late afternoon just prior to the time of cone disc sheddi...

journal_title：Neuron

authors： Pierce ME,Sheshberadaran H,Zhang Z,Fox LE,Applebury ML,Takahashi JS

更新日期：1993-04-01 00:00:00

abstract：:Modification of AMPA receptor function is a major mechanism for the regulation of synaptic transmission and underlies several forms of synaptic plasticity. Post-translational palmitoylation is a reversible modification that regulates localization of many proteins. Here, we report that palmitoylation of the AMPA recept...

journal_title：Neuron

authors： Hayashi T,Rumbaugh G,Huganir RL

更新日期：2005-09-01 00:00:00

abstract：:Visual information reaches the brain by way of a fine cable, the optic nerve. The million or so axons in the optic nerve represent an information bottleneck in the visual pathway-where the fewest number of neurons convey the visual scene. It has long been thought that to make the most of the optic nerve's limited capa...

journal_title：Neuron

authors： Mukamel EA,Schnitzer MJ

更新日期：2005-05-05 00:00:00

abstract：:Both acute and chronic changes in AMPA receptor (AMPAR) localization are critical for synaptic formation, maturation, and plasticity. Here I report that AMPARs are differentially sorted between recycling and degradative pathways following endocytosis. AMPAR sorting occurs in early endosomes and is regulated by synapti...

journal_title：Neuron

authors： Ehlers MD

更新日期：2000-11-01 00:00:00

abstract：:Capsaicin, the main pungent ingredient in "hot" chili peppers, elicits buming pain by activating specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid receptor (VR1) is a cation channel that is also activated by noxious heat. Here, analysis of heat-evoked single channel currents in excised memb...

journal_title：Neuron

authors： Tominaga M,Caterina MJ,Malmberg AB,Rosen TA,Gilbert H,Skinner K,Raumann BE,Basbaum AI,Julius D

更新日期：1998-09-01 00:00:00

abstract：:There has been a surge of interest in how inhibitory neurons influence the output of local circuits in the brain. In this issue of Neuron, Scholl et al. (2015) provide a compelling argument for what one class of inhibitory neurons actually does. ...

journal_title：Neuron

authors： Trachtenberg JT

更新日期：2015-07-15 00:00:00

abstract：:It is a commonly held view that numbers are represented in an abstract way in both parietal lobes. This view is based on failures to find differences between various notational representations. Here we show that by using relatively smaller voxels together with an adaptation paradigm and analyzing subjects on an indivi...

journal_title：Neuron

authors： Cohen Kadosh R,Cohen Kadosh K,Kaas A,Henik A,Goebel R

更新日期：2007-01-18 00:00:00

abstract：:Sweet and bitter taste distinguishes good food sources from potential toxins, but what happens when these tastants are mixed? In this issue of Neuron, Jeong et al. (2013) show that in Drosophila, bitter compounds act through an extracellular odorant-binding protein to inhibit sweet-responsive neurons and block the res...

journal_title：Neuron

authors： Lvovskaya S,Smith DP

更新日期：2013-08-21 00:00:00

abstract：:There have been several recent studies addressing the genetic architecture of depression. This review serves to take stock of what is known now about the genetics of depression, how it has increased our knowledge and understanding of its mechanisms, and how the information and knowledge can be leveraged to improve the...

journal_title：Neuron

authors： McIntosh AM,Sullivan PF,Lewis CM

更新日期：2019-04-03 00:00:00

abstract：:Ephrin signaling through Eph receptor tyrosine kinases can promote attraction or repulsion of axonal growth cones during development. However, the mechanisms that determine whether Eph signaling promotes attraction or repulsion are not known. We show here that the Rho family GEF Vav2 plays a key role in this process. ...

journal_title：Neuron

authors： Cowan CW,Shao YR,Sahin M,Shamah SM,Lin MZ,Greer PL,Gao S,Griffith EC,Brugge JS,Greenberg ME

更新日期：2005-04-21 00:00:00

abstract：:Postlingually deaf subjects learn the meaning of sounds after cochlear implantation by forming new associations between sounds and their sources. Implants generate coarse frequency responses, preventing place-coding fine enough to discriminate sounds with similar temporal characteristics, e.g., buck/duck. This limitat...

journal_title：Neuron

authors： Giraud AL,Price CJ,Graham JM,Truy E,Frackowiak RS

更新日期：2001-06-01 00:00:00

abstract：:alpha-Latrotoxin is a potent stimulator of neurosecretion. Its action requires extracellular binding to high affinity presynaptic receptors. Neurexin I alpha was previously described as a high affinity alpha-latrotoxin receptor that binds the toxin only in the presence of calcium ions. Therefore, the interaction of al...

journal_title：Neuron

authors： Krasnoperov VG,Bittner MA,Beavis R,Kuang Y,Salnikow KV,Chepurny OG,Little AR,Plotnikov AN,Wu D,Holz RW,Petrenko AG

更新日期：1997-06-01 00:00:00

abstract：:Grid cells in medial entorhinal cortex (MEC) can be modeled using oscillatory interference or attractor dynamic mechanisms that perform path integration, a computation requiring information about running direction and speed. The two classes of computational models often use either an oscillatory frequency or a firing ...

journal_title：Neuron

authors： Hinman JR,Brandon MP,Climer JR,Chapman GW,Hasselmo ME

更新日期：2016-08-03 00:00:00

abstract：:The brain mechanisms underlying visual object categorization remain unclear. In this issue of Neuron, Minamimoto and colleagues introduce a novel task that associates each category with a different incentive value, and they demonstrate that it can be learned within a single session even after ablation of the lateral p...

journal_title：Neuron

authors： Buckley MJ,Sigala N

更新日期：2010-05-27 00:00:00

abstract：:The anterior insular cortex (AIC) and its unique spindle-shaped von Economo neuron (VEN) emerged within the last decade as having a potentially major role in self-awareness and social cognition in humans. Invasive examination of the VEN has been precluded so far by the assumption that this neuron occurs among primates...

journal_title：Neuron

authors： Evrard HC,Forro T,Logothetis NK

更新日期：2012-05-10 00:00:00

abstract：:To examine the distribution of synaptic vesicle antigens during development of the cerebral cortex, antibodies against synapsin I and p65 were used on sections of cat cerebral cortex between E40 and adulthood. In the adult, the layers of the cerebral cortex are immunoreactive for each of these antigens, while the whit...

journal_title：Neuron

authors： Chun JJ,Shatz CJ

更新日期：1988-06-01 00:00:00

abstract：:Little is known about the molecular mechanisms underlying differences in the ligand binding properties of AMPA, kainate, and NMDA subtype glutamate receptors. Crystal structures of the GluR5 and GluR6 kainate receptor ligand binding cores in complexes with glutamate, 2S,4R-4-methylglutamate, kainate, and quisqualate h...

journal_title：Neuron

authors： Mayer ML

更新日期：2005-02-17 00:00:00

abstract：:M-current is widespread in the nervous system. It stabilizes cell excitability, and its suppression by muscarinic receptor activation underlies slow synaptic transmission in sympathetic neurons. Suppression of M-current was one of the first examples of neuromodulation of a potassium current, but the mechanism is not u...

journal_title：Neuron

authors： Marrion NV

更新日期：1993-07-01 00:00:00

abstract：:The primate dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) focus attention on relevant signals and suppress noise in cognitive tasks. However, their synaptic interactions and unique roles in cognitive control are unknown. We report that two distinct pathways to DLPFC area 9, one from the ne...

journal_title：Neuron

authors： Medalla M,Barbas H

更新日期：2009-02-26 00:00:00