Abstract:
:The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked mutant forms of superoxide dismutase 1 (SOD1) exhibit an increased sensitivity to death triggered by Fas but not other insults. These data suggest new insights into the mechanisms of, and potential therapeutic strategies for, death of motor neurons in ALS.
journal_name
Neuronjournal_title
Neuronauthors
Xiong ZQ,McNamara JOdoi
10.1016/s0896-6273(02)00910-8subject
Has Abstractpub_date
2002-09-12 00:00:00pages
1011-3issue
6eissn
0896-6273issn
1097-4199pii
S0896627302009108journal_volume
35pub_type
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