Fas(t) balls and Lou Gehrig disease. A clue to selective vulnerability of motor neurons?

Abstract:

:The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked mutant forms of superoxide dismutase 1 (SOD1) exhibit an increased sensitivity to death triggered by Fas but not other insults. These data suggest new insights into the mechanisms of, and potential therapeutic strategies for, death of motor neurons in ALS.

journal_name

Neuron

journal_title

Neuron

authors

Xiong ZQ,McNamara JO

doi

10.1016/s0896-6273(02)00910-8

subject

Has Abstract

pub_date

2002-09-12 00:00:00

pages

1011-3

issue

6

eissn

0896-6273

issn

1097-4199

pii

S0896627302009108

journal_volume

35

pub_type

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