Abstract:
:In this issue of Neuron, Chakrabarty et al. (2015) and Guillot-Sestier et al. (2015) reveal that the anti-inflammatory cytokine IL-10 inhibits Aβ clearance by microglia, worsening cognitive decline in mouse models of Alzheimer's disease (AD). These studies provide further support that pro-inflammatory signaling is an innate immune defense mechanism in AD.
journal_name
Neuronjournal_title
Neuronauthors
Michaud JP,Rivest Sdoi
10.1016/j.neuron.2015.01.021subject
Has Abstractpub_date
2015-02-04 00:00:00pages
450-2issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00047-1journal_volume
85pub_type
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