Abstract:
:We utilized the Cre-LoxP system to establish erbB2 conditional mutant mice in order to investigate the role of erbB2 in postnatal development of the enteric nervous system. The erbB2/nestin-Cre conditional mutants exhibit retarded growth, distended colons, and premature death, resembling human Hirschsprung's disease. Enteric neurons and glia are present at birth in the colon of erbB2/nestin-Cre mutants; however, a marked loss of multiple classes of enteric neurons and glia occurs by 3 weeks of age. Furthermore, we demonstrate that the requirement for erbB2 in maintaining the enteric nervous system is not cell autonomous, but rather erbB2 signaling in the colonic epithelia is required for the postnatal survival of enteric neurons and glia.
journal_name
Neuronjournal_title
Neuronauthors
Crone SA,Negro A,Trumpp A,Giovannini M,Lee KFdoi
10.1016/s0896-6273(02)01128-5subject
Has Abstractpub_date
2003-01-09 00:00:00pages
29-40issue
1eissn
0896-6273issn
1097-4199pii
S0896627302011285journal_volume
37pub_type
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