当前位置： SCI文献检索 > NEURON期刊下所有文献 > Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination.

Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination.

Abstract：

:Painful mechanical stimuli activate multiple peripheral sensory afferent subtypes simultaneously, including nociceptors and low-threshold mechanoreceptors (LTMRs). Using an optogenetic approach, we demonstrate that LTMRs do not solely serve as touch receptors but also play an important role in acute pain signaling. We show that selective activation of neuropeptide Y receptor-2-expressing (Npy2r) myelinated A-fiber nociceptors evokes abnormally exacerbated pain, which is alleviated by concurrent activation of LTMRs in a frequency-dependent manner. We further show that spatial summation of single action potentials from multiple NPY2R-positive afferents is sufficient to trigger nocifensive paw withdrawal, but additional simultaneous sensory input from LTMRs is required for normal well-coordinated execution of this reflex. Thus, our results show that combinatorial coding of noxious and tactile sensory input is required for normal acute mechanical pain signaling. Additionally, we established a causal link between precisely defined neural activity in functionally identified sensory neuron subpopulations and nocifensive behavior and pain.

journal_name

Neuron

journal_title

Neuron

authors

Arcourt A,Gorham L,Dhandapani R,Prato V,Taberner FJ,Wende H,Gangadharan V,Birchmeier C,Heppenstall PA,Lechner SG

doi

10.1016/j.neuron.2016.11.027

subject

Has Abstract

pub_date

2017-01-04 00:00:00

pages

179-193

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(16)30865-0

journal_volume

93

pub_type

杂志文章

相关文献

NEURON文献大全
  • Hox genes: choreographers in neural development, architects of circuit organization.

    abstract：:The neural circuits governing vital behaviors, such as respiration and locomotion, are comprised of discrete neuronal populations residing within the brainstem and spinal cord. Work over the past decade has provided a fairly comprehensive understanding of the developmental pathways that determine the identity of major...

    journal_title：Neuron

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuron.2013.09.020

    authors： Philippidou P,Dasen JS

    更新日期：2013-10-02 00:00:00

  • Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins.

    abstract：:Binding between DIP and Dpr neuronal recognition proteins has been proposed to regulate synaptic connections between lamina and medulla neurons in the Drosophila visual system. Each lamina neuron was previously shown to express many Dprs. Here, we demonstrate, by contrast, that their synaptic partners typically expres...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2018.10.046

    authors： Cosmanescu F,Katsamba PS,Sergeeva AP,Ahlsen G,Patel SD,Brewer JJ,Tan L,Xu S,Xiao Q,Nagarkar-Jaiswal S,Nern A,Bellen HJ,Zipursky SL,Honig B,Shapiro L

    更新日期：2018-12-19 00:00:00

  • Female contact activates male-specific interneurons that trigger stereotypic courtship behavior in Drosophila.

    abstract：:We determined the cellular substrate for male courtship behavior by quasinatural and artificial stimulation of brain neurons. Activation of fruitless (fru)-expressing neurons via stimulation of thermosensitive dTrpA1 channels induced an entire series of courtship acts in male Drosophila placed alone without any courti...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2010.12.017

    authors： Kohatsu S,Koganezawa M,Yamamoto D

    更新日期：2011-02-10 00:00:00

  • A mammalian homolog of Drosophila tumorous imaginal discs, Tid1, mediates agrin signaling at the neuromuscular junction.

    abstract：:Motoneuron-derived agrin clusters nicotinic acetylcholine receptors (AChRs) in mammalian muscle cells. We used two-hybrid screens to identify a protein, tumorous imaginal discs (Tid1), that binds to the cytoplasmic domain of muscle-specific kinase (MuSK), a major component of the agrin receptor. Like MuSK, Tid1 coloca...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2008.09.025

    authors： Linnoila J,Wang Y,Yao Y,Wang ZZ

    更新日期：2008-11-26 00:00:00

  • Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex.

    abstract：:Recent advances in brain imaging techniques, including functional magnetic resonance imaging (fMRI), offer great promise for noninvasive mapping of brain function. However, the indirect nature of the imaging signals to the underlying neural activity limits the interpretation of the resulting maps. The present report r...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(03)00403-3

    authors： Devor A,Dunn AK,Andermann ML,Ulbert I,Boas DA,Dale AM

    更新日期：2003-07-17 00:00:00

  • Overcoming Depression by Inhibition of Neural Burst Firing.

    abstract：:The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving ...

    journal_title：Neuron

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuron.2018.05.032

    authors： Kim D,Cheong E,Shin HS

    更新日期：2018-06-06 00:00:00

  • Triangulating the neural, psychological, and economic bases of guilt aversion.

    abstract：VIDEO ABSTRACT:Why do people often choose to cooperate when they can better serve their interests by acting selfishly? One potential mechanism is that the anticipation of guilt can motivate cooperative behavior. We utilize a formal model of this process in conjunction with fMRI to identify brain regions that mediate co...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2011.02.056

    authors： Chang LJ,Smith A,Dufwenberg M,Sanfey AG

    更新日期：2011-05-12 00:00:00

  • Keeping an eye on cortical states.

    abstract：:Membrane potential recordings in awake mice have correlated cortical state with locomotion and whisker movements. In this issue of Neuron, Reimer et al. (2014) now reveal that pupil dilation in stationary mice equally signals a change in cortical state and an enhancement of visual processing. ...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2014.10.005

    authors： Poulet JF

    更新日期：2014-10-22 00:00:00

  • Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.

    abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) has been described as a biochemical switch that is turned on by increases in intracellular calcium to mediate synaptic plasticity. Here, we show that reductions in CaMKII activity trigger persistent increases in intrinsic excitability. In spontaneously firing ves...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2005.04.009

    authors： Nelson AB,Gittis AH,du Lac S

    更新日期：2005-05-19 00:00:00

  • Discrete Stepping and Nonlinear Ramping Dynamics Underlie Spiking Responses of LIP Neurons during Decision-Making.

    abstract：:Neurons in LIP exhibit ramping trial-averaged responses during decision-making. Recent work sparked debate over whether single-trial LIP spike trains are better described by discrete "stepping" or continuous "ramping" dynamics. We extended latent dynamical spike train models and used Bayesian model comparison to addre...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2019.04.031

    authors： Zoltowski DM,Latimer KW,Yates JL,Huk AC,Pillow JW

    更新日期：2019-06-19 00:00:00

  • Biallelic Mutations in MYORG Cause Autosomal Recessive Primary Familial Brain Calcification.

    abstract：:Primary familial brain calcification (PFBC) is a genetically heterogeneous disorder characterized by bilateral calcifications in the basal ganglia and other brain regions. The genetic basis of this disorder remains unknown in a significant portion of familial cases. Here, we reported a recessive causal gene, MYORG, fo...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2018.05.037

    authors： Yao XP,Cheng X,Wang C,Zhao M,Guo XX,Su HZ,Lai LL,Zou XH,Chen XJ,Zhao Y,Dong EL,Lu YQ,Wu S,Li X,Fan G,Yu H,Xu J,Wang N,Xiong ZQ,Chen WJ

    更新日期：2018-06-27 00:00:00

  • Great Expectations: Anticipatory Control of Magnocellular Vasopressin Neurons.

    abstract：:Real-time activity measurements of genetically identified neuroendocrine vasopressin neurons show they can anticipate osmotic challenges. In this issue of Neuron, Mandelblat-Cerf et al. (2017) show that correlating these results with ongoing behavior and plasma osmolality points to the existence of brain networks that...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2016.12.033

    authors： Watts AG

    更新日期：2017-01-04 00:00:00

  • Constitutively active mutants of rhodopsin.

    abstract：:Two critical amino acids in the visual pigment rhodopsin are Lys-296, the site of attachment of retinal to the protein through a protonated Schiff base linkage, and Glu-113, the Schiff base counterion. Mutation of Lys-296 or Glu-113 results in constitutive activation of opsin, as assayed by its ability to activate tra...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(92)90034-b

    authors： Robinson PR,Cohen GB,Zhukovsky EA,Oprian DD

    更新日期：1992-10-01 00:00:00

  • Linx mediates interaxonal interactions and formation of the internal capsule.

    abstract：:During the development of forebrain connectivity, ascending thalamocortical and descending corticofugal axons first intermingle at the pallial-subpallial boundary to form the internal capsule (IC). However, the identity of molecular cues that guide these axons remains largely unknown. Here, we show that the transmembr...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2014.05.020

    authors： Mandai K,Reimert DV,Ginty DD

    更新日期：2014-07-02 00:00:00

  • The cerebrospinal fluid provides a proliferative niche for neural progenitor cells.

    abstract：:Cortical development depends on the active integration of cell-autonomous and extrinsic cues, but the coordination of these processes is poorly understood. Here, we show that the apical complex protein Pals1 and Pten have opposing roles in localizing the Igf1R to the apical, ventricular domain of cerebral cortical pro...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2011.01.023

    authors： Lehtinen MK,Zappaterra MW,Chen X,Yang YJ,Hill AD,Lun M,Maynard T,Gonzalez D,Kim S,Ye P,D'Ercole AJ,Wong ET,LaMantia AS,Walsh CA

    更新日期：2011-03-10 00:00:00

  • Programmed to be human?

    abstract：:Pletikos et al. (2014) demonstrate in this issue of Neuron that the human neocortex has an "hourglass" temporal gene expression pattern with robust and dynamic transcriptome differences during the prenatal and adolescent/adult periods. Similar changes are not observed in the nonhuman primate-is this what makes us huma...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2014.01.006

    authors： Korade Z,Mirnics K

    更新日期：2014-01-22 00:00:00

  • Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor.

    abstract：:To assess the necessary parameters for the growth of axons within the adult rat CNS, we have used intracerebral grafts of primary fibroblasts genetically engineered to express nerve growth factor (NGF). Following the implantation of NGF-producing primary fibroblasts within the striatum, cholinergic axons arising from ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(91)90346-2

    authors： Kawaja MD,Gage FH

    更新日期：1991-12-01 00:00:00

  • Spatiotemporal dynamics underlying object completion in human ventral visual cortex.

    abstract：:Natural vision often involves recognizing objects from partial information. Recognition of objects from parts presents a significant challenge for theories of vision because it requires spatial integration and extrapolation from prior knowledge. Here we recorded intracranial field potentials of 113 visually selective ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2014.06.017

    authors： Tang H,Buia C,Madhavan R,Crone NE,Madsen JR,Anderson WS,Kreiman G

    更新日期：2014-08-06 00:00:00

  • Increased l1 retrotransposition in the neuronal genome in schizophrenia.

    abstract：:Recent studies indicate that long interspersed nuclear element-1 (L1) are mobilized in the genome of human neural progenitor cells and enhanced in Rett syndrome and ataxia telangiectasia. However, whether aberrant L1 retrotransposition occurs in mental disorders is unknown. Here, we report high L1 copy number in schiz...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2013.10.053

    authors： Bundo M,Toyoshima M,Okada Y,Akamatsu W,Ueda J,Nemoto-Miyauchi T,Sunaga F,Toritsuka M,Ikawa D,Kakita A,Kato M,Kasai K,Kishimoto T,Nawa H,Okano H,Yoshikawa T,Kato T,Iwamoto K

    更新日期：2014-01-22 00:00:00

  • Molecular cloning of multiple subtypes of a novel rat brain isoform of the alpha 1 subunit of the voltage-dependent calcium channel.

    abstract：:Several cDNAs encoding an isoform of the alpha 1 subunit of the voltage-dependent calcium channel were isolated from rat brain cDNA libraries. The complete nucleotide sequence of 6975 bp encodes a protein of 1634 amino acids, which corresponds to an Mr of 186,968. The protein exhibits 71% and 76% homology to skeletal ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(91)90072-8

    authors： Hui A,Ellinor PT,Krizanova O,Wang JJ,Diebold RJ,Schwartz A

    更新日期：1991-07-01 00:00:00

  • Glial cells maintain synaptic structure and function and promote development of the neuromuscular junction in vivo.

    abstract：:To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(03)00682-2

    authors： Reddy LV,Koirala S,Sugiura Y,Herrera AA,Ko CP

    更新日期：2003-10-30 00:00:00

  • Fool me once, shame on you; fool me twice, shame on oxytocin.

    abstract：:In this issue of Neuron, a study by Baumgartner et al. investigates the influence of oxytocin on trust behavior and its neural mechanisms. The authors report that, following breaches of trust, oxytocin facilitates prosocial behavior while modulating neural signals in the amygdala and caudate nucleus. The findings have...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2008.05.005

    authors： Delgado MR

    更新日期：2008-05-22 00:00:00

  • Long-distance control of synapse assembly by target-derived NGF.

    abstract：:We report a role for long-distance retrograde neurotrophin signaling in the establishment of synapses in the sympathetic nervous system. Target-derived NGF is both necessary and sufficient for formation of postsynaptic specializations on dendrites of sympathetic neurons. This, in turn, is a prerequisite for formation ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2010.07.018

    authors： Sharma N,Deppmann CD,Harrington AW,St Hillaire C,Chen ZY,Lee FS,Ginty DD

    更新日期：2010-08-12 00:00:00

  • Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25.

    abstract：:Protein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain elusive. We combined pharmacological manipulations of kinase and phosphatase activities with mutational studies on the exocytotic machinery driving fusion of catecholamine-containing vesicles from chromaffin cells. We found t...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(04)00038-8

    authors： Nagy G,Reim K,Matti U,Brose N,Binz T,Rettig J,Neher E,Sørensen JB

    更新日期：2004-02-05 00:00:00

  • Immunological characterization of K+ channel components from the Shaker locus and differential distribution of splicing variants in Drosophila.

    abstract：:Antibodies were raised to three portions of the predicted sequences of Shaker, a gene that encodes a family of K+ channel components that are produced by the alternative splicing of transcripts. On immunoblots, the protein products appear to be 65,000-85,000 daltons in size. No smaller products were detected. Immunocy...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(90)90448-o

    authors： Schwarz TL,Papazian DM,Carretto RC,Jan YN,Jan LY

    更新日期：1990-01-01 00:00:00

  • Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks.

    abstract：:Alzheimer's disease is characterized by the deposition of senile plaques and progressive dementia. The molecular mechanisms that couple plaque deposition to neural system failure, however, are unknown. Using transgenic mouse models of AD together with multiphoton imaging, we measured neuronal calcium in individual neu...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2008.06.008

    authors： Kuchibhotla KV,Goldman ST,Lattarulo CR,Wu HY,Hyman BT,Bacskai BJ

    更新日期：2008-07-31 00:00:00

  • Dynamic processes shape spatiotemporal properties of retinal waves.

    abstract：:In the developing mammalian retina, spontaneous waves of action potentials are present in the ganglion cell layer weeks before vision. These waves are known to be generated by a synaptically connected network of amacrine cells and retinal ganglion cells, and exhibit complex spatiotemporal patterns, characterized by sh...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(00)80940-x

    authors： Feller MB,Butts DA,Aaron HL,Rokhsar DS,Shatz CJ

    更新日期：1997-08-01 00:00:00

  • Internally Recurring Hippocampal Sequences as a Population Template of Spatiotemporal Information.

    abstract：:The hippocampus is essential for spatiotemporal cognition. Sequences of neuronal activation provide a substrate for this fundamental function. At the behavioral timescale, these sequences have been shown to occur either in the presence of successive external landmarks or through internal mechanisms within an episodic ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2015.09.052

    authors： Villette V,Malvache A,Tressard T,Dupuy N,Cossart R

    更新日期：2015-10-21 00:00:00

  • Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo.

    abstract：:Inhibitors in myelin play a major role in preventing spontaneous axonal regeneration after CNS injury. Elevation of cAMP overcomes this inhibition, in a transcription-dependent manner, through the upregulation of Arginase I (Arg I) and increased synthesis of polyamines. Here, we show that the cAMP effect requires acti...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2004.10.030

    authors： Gao Y,Deng K,Hou J,Bryson JB,Barco A,Nikulina E,Spencer T,Mellado W,Kandel ER,Filbin MT

    更新日期：2004-11-18 00:00:00

  • Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.

    abstract：:The frontline anti-malarial drug artemisinin and its derivatives have also been implicated in modulating multiple mammalian cellular pathways, including the recent identification of targeting γ-aminobutyric acid type A receptor (GABAAR) signaling in the pancreas. Their molecular mechanism of action, however, remains e...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2019.01.001

    authors： Kasaragod VB,Hausrat TJ,Schaefer N,Kuhn M,Christensen NR,Tessmer I,Maric HM,Madsen KL,Sotriffer C,Villmann C,Kneussel M,Schindelin H

    更新日期：2019-02-20 00:00:00