Keeping an eye on cortical states.

abstract：:We have used biochemical and immunocytochemical techniques to investigate the possible involvement of membrane cytoskeletal elements such as alpha-actinin, calspectin (brain spectrin or fodrin), and actin in growth cone activities. During NGF-induced differentiation of PC12 cells, alpha-actinin increased in associatio...

journal_title：Neuron

authors： Sobue K,Kanda K

更新日期：1989-09-01 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) has been described as a biochemical switch that is turned on by increases in intracellular calcium to mediate synaptic plasticity. Here, we show that reductions in CaMKII activity trigger persistent increases in intrinsic excitability. In spontaneously firing ves...

journal_title：Neuron

authors： Nelson AB,Gittis AH,du Lac S

更新日期：2005-05-19 00:00:00

abstract：:Visual experience before eye-opening is not usually thought to have any developmental significance. Here we show that naturalistic visual stimuli presented through unopened eyelids robustly activate neurons in the ferret dorsal lateral geniculate nucleus. Further, dark-rearing prior to natural eye-opening has striking...

journal_title：Neuron

authors： Akerman CJ,Smyth D,Thompson ID

更新日期：2002-12-05 00:00:00

abstract：:Within the medial frontal cortex, the supplementary eye field (SEF), supplementary motor area (SMA), and pre-SMA have been implicated in the control of voluntary action, especially during motor sequences or tasks involving rapid choices between competing response plans. However, the precise roles of these areas remain...

journal_title：Neuron

authors： Sumner P,Nachev P,Morris P,Peters AM,Jackson SR,Kennard C,Husain M

更新日期：2007-06-07 00:00:00

abstract：:Circadian clock proteins are modified in many different ways. The best-studied posttranslational modification is phosphorylation, with well-known kinases and phosphatases regulating the function and stability of clock proteins. Degradation of these proteins usually involves ubiquitylation or sumoylation, and some of t...

journal_title：Neuron

authors： Sehgal A

更新日期：2008-01-10 00:00:00

abstract：:Neuromodulators regulate circuits throughout the nervous system, and revealing the cell types and stimulus conditions controlling their release is vital to understanding their function. The effects of the neuromodulator nitric oxide (NO) have been studied in many circuits, including in the vertebrate retina, where it ...

journal_title：Neuron

authors： Jacoby J,Nath A,Jessen ZF,Schwartz GW

更新日期：2018-12-05 00:00:00

abstract：:To investigate the role of the pathogenic prion protein (PrP(Sc)) in controlling susceptibility to foreign prions, two Syrian hamster (SHa) prion strains, Sc237 and DY, were transmitted to transgenic mice expressing chimeric SHa/mouse PrP genes, Tg(MH2M). First passage of SHa(Sc237) prions exhibited prolonged incubati...

journal_title：Neuron

authors： Peretz D,Williamson RA,Legname G,Matsunaga Y,Vergara J,Burton DR,DeArmond SJ,Prusiner SB,Scott MR

更新日期：2002-06-13 00:00:00

abstract：:To characterize the role of rare complete human knockouts in autism spectrum disorders (ASDs), we identify genes with homozygous or compound heterozygous loss-of-function (LoF) variants (defined as nonsense and essential splice sites) from exome sequencing of 933 cases and 869 controls. We identify a 2-fold increase i...

journal_title：Neuron

authors： Lim ET,Raychaudhuri S,Sanders SJ,Stevens C,Sabo A,MacArthur DG,Neale BM,Kirby A,Ruderfer DM,Fromer M,Lek M,Liu L,Flannick J,Ripke S,Nagaswamy U,Muzny D,Reid JG,Hawes A,Newsham I,Wu Y,Lewis L,Dinh H,Gross S,W

更新日期：2013-01-23 00:00:00

abstract：:Olfactory information is first encoded in a combinatorial fashion by olfactory bulb glomeruli, which individually represent distinct chemical features of odors. This information is then transmitted to piriform (olfactory) cortex, via axons of olfactory bulb mitral and tufted (M/T) cells, where it is presumed to form t...

journal_title：Neuron

authors： Franks KM,Isaacson JS

更新日期：2006-02-02 00:00:00

abstract：:I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer subunits are compared to those with linked subunits that force defined stoichiometries. Two strategies that exploit charybd...

journal_title：Neuron

authors： Chen H,Kim LA,Rajan S,Xu S,Goldstein SA

更新日期：2003-09-25 00:00:00

abstract：:In uncertain environments, decision-makers must balance two goals: they must "exploit" rewarding options but also "explore" in order to discover rewarding alternatives. Exploring and exploiting necessarily change how the brain responds to identical stimuli, but little is known about how these states, and transitions b...

journal_title：Neuron

authors： Ebitz RB,Albarran E,Moore T

更新日期：2018-01-17 00:00:00

abstract：:We perceive motion when presented with spatiotemporal changes in contrast (second-order cue). This requires linear signals to be rectified and then summed in temporal order to compute direction. Although both operations have been attributed to cortex, rectification might occur in retina, prior to the ganglion cell. He...

journal_title：Neuron

authors： Demb JB,Zaghloul K,Sterling P

更新日期：2001-11-20 00:00:00

abstract：:Secretion principles are conserved from yeast to humans, and many yeast orthologs have established roles in synaptic vesicle exocytosis in the mammalian brain. Surprisingly, SEC4 orthologs and their effectors, the exocyst, are dispensable for synaptic vesicle exocytosis. Here, we identify the SEC4 ortholog RAB3 and it...

journal_title：Neuron

authors： Persoon CM,Hoogstraaten RI,Nassal JP,van Weering JRT,Kaeser PS,Toonen RF,Verhage M

更新日期：2019-12-18 00:00:00

abstract：:Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presy...

journal_title：Neuron

authors： Varoqueaux F,Aramuni G,Rawson RL,Mohrmann R,Missler M,Gottmann K,Zhang W,Südhof TC,Brose N

更新日期：2006-09-21 00:00:00

abstract：:Dopamine neurons in the ventral tegmental area (VTA) play an important role in the motivational systems underlying drug addiction, and recent work has suggested that they also release the excitatory neurotransmitter glutamate. To assess a physiological role for glutamate corelease, we disrupted the expression of vesic...

journal_title：Neuron

authors： Hnasko TS,Chuhma N,Zhang H,Goh GY,Sulzer D,Palmiter RD,Rayport S,Edwards RH

更新日期：2010-03-11 00:00:00

abstract：:Phosphorylation of brain Na+ channels by protein kinase C (PKC) decreases peak Na+ current and slows macroscopic inactivation, but receptor-activated modulation of Na+ currents via the PKC pathway has not been demonstrated. We have examined modulation of Na+ channels by activation of muscarinic receptors in acutely-is...

journal_title：Neuron

authors： Cantrell AR,Ma JY,Scheuer T,Catterall WA

更新日期：1996-05-01 00:00:00

abstract：:People are embedded in social interaction that shapes their brains throughout lifetime. Instead of emerging from lower-level cognitive functions, social interaction could be the default mode via which humans communicate with their environment. Should this hypothesis be true, it would have profound implications on how ...

journal_title：Neuron

authors： Hari R,Henriksson L,Malinen S,Parkkonen L

更新日期：2015-10-07 00:00:00

abstract：:In this issue of Neuron, Luo and Maunsell (2018) use signal detection theory to demonstrate that the modulatory effects of attention on neuronal responses in the lateral prefrontal cortex during change detection can be due to changes in an observer's sensitivity or shifts in their response criterion. ...

journal_title：Neuron

authors： Martinez-Trujillo J,Gulli RA

更新日期：2018-03-21 00:00:00

abstract：:Cortical GABAergic interneurons have essential roles for information processing and their dysfunction is implicated in neuropsychiatric disorders. Transcriptional codes are elucidating mechanisms of interneuron specification in the MGE (a subcortical progenitor zone), which regulate their migration, integration, and f...

journal_title：Neuron

authors： Vogt D,Hunt RF,Mandal S,Sandberg M,Silberberg SN,Nagasawa T,Yang Z,Baraban SC,Rubenstein JL

更新日期：2014-04-16 00:00:00

abstract：:GABARAP recognizes and binds the gamma2 subunit of the GABA(A) receptor, interacts with microtubules and the N-ethyl maleimide sensitive factor, and is proposed to function in GABA(A) receptor trafficking and postsynaptic localization. We have determined the crystal structure of human GABARAP at 1.6 A resolution. The ...

journal_title：Neuron

authors： Coyle JE,Qamar S,Rajashankar KR,Nikolov DB

更新日期：2002-01-03 00:00:00

abstract：:Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...

journal_title：Neuron

authors： Divakaruni SS,Van Dyke AM,Chandra R,LeGates TA,Contreras M,Dharmasri PA,Higgs HN,Lobo MK,Thompson SM,Blanpied TA

更新日期：2018-11-21 00:00:00

abstract：:Human confidence judgments are thought to originate from metacognitive processes that provide a subjective assessment about one's beliefs. Alternatively, confidence is framed in mathematics as an objective statistical quantity: the probability that a chosen hypothesis is correct. Despite similar terminology, it remain...

journal_title：Neuron

authors： Sanders JI,Hangya B,Kepecs A

更新日期：2016-05-04 00:00:00

abstract：:We investigated the contribution of the inferior temporal (IT) cortical neurons to the active maintenance of internal representations. The activity of single neurons in the IT cortex was recorded while the monkeys performed a sequential-type associative memory task in which distractor stimuli interrupted the delay epo...

journal_title：Neuron

authors： Takeda M,Naya Y,Fujimichi R,Takeuchi D,Miyashita Y

更新日期：2005-12-08 00:00:00

abstract：:Neurabin and spinophilin are homologous protein phosphatase 1 and actin binding proteins that regulate dendritic spine function. A yeast two-hybrid analysis using the coiled-coil domain of neurabin revealed an interaction with Lfc, a Rho GEF. Lfc was highly expressed in brain, where it interacted with either neurabin ...

journal_title：Neuron

authors： Ryan XP,Alldritt J,Svenningsson P,Allen PB,Wu GY,Nairn AC,Greengard P

更新日期：2005-07-07 00:00:00

abstract：:Live imaging studies in mice show that adult-born oligodendrocytes and myelin are remarkably stable. Neural activity enhances oligodendrocyte integration, arguing that internode addition rather than alteration represents the mechanism for any experience-dependent cortical myelination changes that might underpin learni...

journal_title：Neuron

authors： Swire M,Ffrench-Constant C

更新日期：2018-05-16 00:00:00

abstract：:A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development. Here, we demonstrate that Reelin binds directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and...

journal_title：Neuron

authors： D'Arcangelo G,Homayouni R,Keshvara L,Rice DS,Sheldon M,Curran T

更新日期：1999-10-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category of transcripts that have expanded greatly in primates, particularly in the brain. We identified an lncRNA, which has acquired 16 microRNA response elements for miR-143-3p in the Catarrhini branch of primates. This lncRNA, termed LncND (neurodev...

journal_title：Neuron

authors： Rani N,Nowakowski TJ,Zhou H,Godshalk SE,Lisi V,Kriegstein AR,Kosik KS

更新日期：2016-06-15 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective demise of specific neuronal populations leading to impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are implicated in the biochemical ...

journal_title：Neuron

authors： Giasson BI,Lee VM

更新日期：2001-09-27 00:00:00

abstract：:Interactions between genetic and epigenetic effects shape brain function, behavior, and the risk for mental illness. Random X inactivation and genomic imprinting are epigenetic allelic effects that are well known to influence genetic architecture and disease risk. Less is known about the nature, prevalence, and conser...

journal_title：Neuron

authors： Huang WC,Ferris E,Cheng T,Hörndli CS,Gleason K,Tamminga C,Wagner JD,Boucher KM,Christian JL,Gregg C

更新日期：2017-03-08 00:00:00

abstract：:Neuronal population responses can vary across trials as a result of differences in the relative timing of internal brain processes. In this issue of Neuron, Williams et al. (2020) present an algorithm for inferring and inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal st...

journal_title：Neuron

authors： Okun M

更新日期：2020-01-22 00:00:00