Sex Differences in Susceptibility to Depression: A Role for LncRNAs.

abstract：:Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells. ...

journal_title：Neuron

authors： Dyhrfjeld-Johnsen J,Soltesz I

更新日期：2004-10-28 00:00:00

abstract：:When faced with a crowded visual scene, observers must selectively attend to behaviorally relevant objects to avoid sensory overload. Often this selection process is guided by prior knowledge of a target-defining feature (e.g., the color red when looking for an apple), which enhances the firing rate of visual neurons ...

journal_title：Neuron

authors： Serences JT,Boynton GM

更新日期：2007-07-19 00:00:00

abstract：:Mutations in the retinal degeneration, retinal degeneration slow(/peripherin) and rhodopsin genes cause photoreceptor degeneration in humans and mice. Although the phenotypes arising from these mutations are different, suggesting different mechanisms of pathogenesis, we present evidence that apoptosis may be the final...

journal_title：Neuron

authors： Chang GQ,Hao Y,Wong F

更新日期：1993-10-01 00:00:00

abstract：VIDEO ABSTRACT:Why do people often choose to cooperate when they can better serve their interests by acting selfishly? One potential mechanism is that the anticipation of guilt can motivate cooperative behavior. We utilize a formal model of this process in conjunction with fMRI to identify brain regions that mediate co...

journal_title：Neuron

authors： Chang LJ,Smith A,Dufwenberg M,Sanfey AG

更新日期：2011-05-12 00:00:00

abstract：:Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ ...

journal_title：Neuron

authors： Alcamo EA,Chirivella L,Dautzenberg M,Dobreva G,Fariñas I,Grosschedl R,McConnell SK

更新日期：2008-02-07 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the P362L mutation in the low-complexity domain (LCD) of T cell-rest...

journal_title：Neuron

authors： Mackenzie IR,Nicholson AM,Sarkar M,Messing J,Purice MD,Pottier C,Annu K,Baker M,Perkerson RB,Kurti A,Matchett BJ,Mittag T,Temirov J,Hsiung GR,Krieger C,Murray ME,Kato M,Fryer JD,Petrucelli L,Zinman L,Weintraub S,

更新日期：2017-08-16 00:00:00

abstract：:The regulation of quantal size through pre- rather than postsynaptic mechanisms has recently received considerable attention as a potential mechanism for plasticity. Vesicular transporters catalyze the filling of synaptic vesicles with transmitter and are thus potential substrates for such presynaptic regulation. In t...

journal_title：Neuron

authors： Hnasko TS,Edwards RH

更新日期：2006-09-07 00:00:00

abstract：:Capsaicin, the main pungent ingredient in "hot" chili peppers, elicits buming pain by activating specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid receptor (VR1) is a cation channel that is also activated by noxious heat. Here, analysis of heat-evoked single channel currents in excised memb...

journal_title：Neuron

authors： Tominaga M,Caterina MJ,Malmberg AB,Rosen TA,Gilbert H,Skinner K,Raumann BE,Basbaum AI,Julius D

更新日期：1998-09-01 00:00:00

abstract：:The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RI...

journal_title：Neuron

authors： Ceni C,Barker PA

更新日期：2005-06-16 00:00:00

abstract：:Sensory information is encoded both in space and in time. Spatial encoding is based on the identity of activated receptors, while temporal encoding is based on the timing of activation. In order to generate accurate internal representations of the external world, the brain must decode both types of encoded information...

journal_title：Neuron

authors： Ahissar E,Arieli A

更新日期：2001-10-25 00:00:00

abstract：:Nociceptin opioid peptide receptor agonists interact with mu-opioid receptor agonists for pain relief. A new study by Ding et al. (2018) examines a bifunctional nociceptin- and mu-opioid receptor agonist, AT-121, that provides analgesia without physiological side effects or abuse liability, offering a promising new ho...

journal_title：Neuron

authors： Parker KE,Bruchas MR

更新日期：2018-12-19 00:00:00

abstract：:Since the inflammatory process develops after transplantation to the brain, we sought to determine the presence of cytokines following a surgical trauma to the brain of an adult mouse. We report the early and marked presence of tumor necrosis factor-alpha and interleukin-1 alpha in neuronal somata of the striatum foll...

journal_title：Neuron

authors： Tchelingerian JL,Quinonero J,Booss J,Jacque C

更新日期：1993-02-01 00:00:00

abstract：:Signaling classically involves the secretion of diverse molecules that bind specific cell-surface receptors and engage intracellular transduction cascades. Some exceptions-namely, lipophilic agents-can cross plasma membranes to bind intracellular receptors and be carried to the nucleus to regulate transcription. Homeo...

journal_title：Neuron

authors： Prochiantz A,Di Nardo AA

更新日期：2015-03-04 00:00:00

abstract：:Perceptual learning is a lifelong process. We begin by encoding information about the basic structure of the natural world and continue to assimilate information about specific patterns with which we become familiar. The specificity of the learning suggests that all areas of the cerebral cortex are plastic and can rep...

journal_title：Neuron

authors： Gilbert CD,Sigman M,Crist RE

更新日期：2001-09-13 00:00:00

abstract：:Locomotion requires coordinated motor activity throughout an animal's body. In both vertebrates and invertebrates, chains of coupled central pattern generators (CPGs) are commonly evoked to explain local rhythmic behaviors. In C. elegans, we report that proprioception within the motor circuit is responsible for propag...

journal_title：Neuron

authors： Wen Q,Po MD,Hulme E,Chen S,Liu X,Kwok SW,Gershow M,Leifer AM,Butler V,Fang-Yen C,Kawano T,Schafer WR,Whitesides G,Wyart M,Chklovskii DB,Zhen M,Samuel AD

更新日期：2012-11-21 00:00:00

abstract：:Neurons propagate information through circuits by integrating thousands of synaptic inputs to generate an action potential output. Inputs from different origins are often targeted to distinct regions of a neuron's dendritic tree, with synapses on more distal dendrites normally having a weaker influence on cellular out...

journal_title：Neuron

authors： Chevaleyre V,Siegelbaum SA

更新日期：2010-05-27 00:00:00

abstract：:Neuroanatomical and functional asymmetries are universal features of the vertebrate CNS, but how asymmetry is generated is unknown. Here we show that zebrafish fgf8 mutants do not elaborate forebrain asymmetries, demonstrated by the failure of the parapineal nucleus to migrate from its initial midline position to the ...

journal_title：Neuron

authors： Regan JC,Concha ML,Roussigne M,Russell C,Wilson SW

更新日期：2009-01-15 00:00:00

abstract：:Accumulation of specific proteins at synaptic structures is essential for synapse assembly and function, but mechanisms regulating local protein enrichment remain poorly understood. At the neuromuscular junction (NMJ), subsynaptic nuclei underlie motor axon terminals within extrafusal muscle fibers and are transcripti...

journal_title：Neuron

authors： Hippenmeyer S,Huber RM,Ladle DR,Murphy K,Arber S

更新日期：2007-09-06 00:00:00

abstract：:Through specific intersubunit contacts, the four subunits of the nicotinic acetylcholine receptor assemble into an alpha 2 beta gamma delta pentamer. The specificity of subunit association leads to formation of proper ligand binding sites and to transport of assembled pentamers to the cell surface. To identify determi...

journal_title：Neuron

authors： Kreienkamp HJ,Maeda RK,Sine SM,Taylor P

更新日期：1995-03-01 00:00:00

abstract：:A fundamental question about the neural correlates of attention concerns the earliest sensory processing stage that it can affect. We addressed this issue by recording magnetoencephalography (MEG) signals while subjects performed detection tasks, which required employment of spatial or nonspatial attention, in auditor...

journal_title：Neuron

authors： Poghosyan V,Ioannides AA

更新日期：2008-06-12 00:00:00

abstract：:We recently reported that homozygous Presenilin-1 (Psen1) knockin (KI) mice carrying the familial Alzheimer's disease (FAD) mutation L435F or C410Y recapitulate the phenotypes of Psen1(-/-) mice. Production and steady-state levels of Aβ40 and Aβ42 are undetectable in KI/KI brains and reduced in KI/+ brains, though the...

journal_title：Neuron

authors： Xia D,Kelleher RJ 3rd,Shen J

更新日期：2016-04-20 00:00:00

abstract：:Glucose-inhibited neurons orchestrate behavior and metabolism according to body energy levels, but how glucose inhibits these cells is unknown. We studied glucose inhibition of orexin/hypocretin neurons, which promote wakefulness (their loss causes narcolepsy) and also regulate metabolism and reward. Here we demonstra...

journal_title：Neuron

authors： Burdakov D,Jensen LT,Alexopoulos H,Williams RH,Fearon IM,O'Kelly I,Gerasimenko O,Fugger L,Verkhratsky A

更新日期：2006-06-01 00:00:00

abstract：:Memory encoding and retrieval require directional exchange of information between different areas in the medial temporal lobe. In this issue of Neuron, Koster et al. (2018) use high-resolution fMRI combined with state-of-the-art data analysis methods to trace the information flow in memory circuits in hippocampus and ...

journal_title：Neuron

authors： Goense J

更新日期：2018-09-19 00:00:00

abstract：:Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFR alpha), suggesting that PDGF mediates a paracrine interaction between these cells. T...

journal_title：Neuron

authors： Fruttiger M,Calver AR,Krüger WH,Mudhar HS,Michalovich D,Takakura N,Nishikawa S,Richardson WD

更新日期：1996-12-01 00:00:00

abstract：:A neural network can sustain and switch between different activity patterns to execute multiple behaviors. By monitoring the decision making for directional locomotion through motor circuit calcium imaging in behaving Caenorhabditis elegans (C. elegans), we reveal that C. elegans determines the directionality of movem...

journal_title：Neuron

authors： Kawano T,Po MD,Gao S,Leung G,Ryu WS,Zhen M

更新日期：2011-11-17 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category of transcripts that have expanded greatly in primates, particularly in the brain. We identified an lncRNA, which has acquired 16 microRNA response elements for miR-143-3p in the Catarrhini branch of primates. This lncRNA, termed LncND (neurodev...

journal_title：Neuron

authors： Rani N,Nowakowski TJ,Zhou H,Godshalk SE,Lisi V,Kriegstein AR,Kosik KS

更新日期：2016-06-15 00:00:00

abstract：:The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3...

journal_title：Neuron

authors： Hippenmeyer S,Shneider NA,Birchmeier C,Burden SJ,Jessell TM,Arber S

更新日期：2002-12-19 00:00:00

abstract：:We describe the isolation and characterization of a cDNA encoding the alpha subunit of a new voltage-sensitive sodium channel, microI, from rat skeletal muscle. The 1840 amino acid microI peptide is homologous to alpha subunits from rat brain, but, like the protein from eel electroplax, lacks an extended (approximatel...

journal_title：Neuron

authors： Trimmer JS,Cooperman SS,Tomiko SA,Zhou JY,Crean SM,Boyle MB,Kallen RG,Sheng ZH,Barchi RL,Sigworth FJ

更新日期：1989-07-01 00:00:00

abstract：:Primates can learn to recognize a virtually limitless number of visual objects. A candidate neural substrate for this adult plasticity is the inferior temporal cortex (ITC). Using a large stimulus set, we explored the impact that long-term experience has on the response properties of two classes of neurons in ITC: bro...

journal_title：Neuron

authors： Woloszyn L,Sheinberg DL

更新日期：2012-04-12 00:00:00

abstract：:Neuropilins are receptors for class 3 secreted semaphorins, most of which can function as potent repulsive axon guidance cues. We have generated mice with a targeted deletion in the neuropilin-2 (Npn-2) locus. Many Npn-2 mutant mice are viable into adulthood, allowing us to assess the role of Npn-2 in axon guidance ev...

journal_title：Neuron

authors： Giger RJ,Cloutier JF,Sahay A,Prinjha RK,Levengood DV,Moore SE,Pickering S,Simmons D,Rastan S,Walsh FS,Kolodkin AL,Ginty DD,Geppert M

更新日期：2000-01-01 00:00:00