Abstract:
:Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we comprehensively identified each area's monosynaptic inputs using the rabies virus. We show that dopamine neurons in both areas integrate inputs from a more diverse collection of areas than previously thought, including autonomic, motor, and somatosensory areas. SNc and VTA dopamine neurons receive contrasting excitatory inputs: the former from the somatosensory/motor cortex and subthalamic nucleus, which may explain their short-latency responses to salient events; and the latter from the lateral hypothalamus, which may explain their involvement in value coding. We demonstrate that neurons in the striatum that project directly to dopamine neurons form patches in both the dorsal and ventral striatum, whereas those projecting to GABAergic neurons are distributed in the matrix compartment. Neuron-type-specific connectivity lays a foundation for studying how dopamine neurons compute outputs.
journal_name
Neuronjournal_title
Neuronauthors
Watabe-Uchida M,Zhu L,Ogawa SK,Vamanrao A,Uchida Ndoi
10.1016/j.neuron.2012.03.017subject
Has Abstractpub_date
2012-06-07 00:00:00pages
858-73issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(12)00281-4journal_volume
74pub_type
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