Abstract:
:The interactions between cortical and hippocampal circuits are critical for memory formation, yet their basic organization at the neuronal network level is not well understood. Here, we demonstrate that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hippocampal theta rhythm. In addition, we show that prefrontal neurons phase lock best to theta oscillations delayed by approximately 50 ms and confirm this hippocampo-prefrontal directionality and timing at the level of correlations between single cells. Finally, we find that phase locking of prefrontal cells is predicted by the presence of significant correlations with hippocampal cells at positive delays up to 150 ms. The theta-entrained activity across cortico-hippocampal circuits described here may be important for gating information flow and guiding the plastic changes that are believed to underlie the storage of information across these networks.
journal_name
Neuronjournal_title
Neuronauthors
Siapas AG,Lubenov EV,Wilson MAdoi
10.1016/j.neuron.2005.02.028subject
Has Abstractpub_date
2005-04-07 00:00:00pages
141-51issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(05)00197-2journal_volume
46pub_type
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