Enigmas of the dentate gyrus.

abstract：:Blood-feeding mosquitoes survive by feeding on nectar for metabolic energy but require a blood meal to develop eggs. Aedes aegypti females must accurately discriminate blood and nectar because each meal promotes mutually exclusive feeding programs with distinct sensory appendages, meal sizes, digestive tract targets, ...

journal_title：Neuron

authors： Jové V,Gong Z,Hol FJH,Zhao Z,Sorrells TR,Carroll TS,Prakash M,McBride CS,Vosshall LB

更新日期：2020-12-23 00:00:00

abstract：:Deciding when to exploit what is already known and when to explore new possibilities is crucial for adapting to novel and dynamic environments. Using reinforcement-based decision making, Costa et al. (2019) in this issue of Neuron find that neurons in the amygdala and ventral-striatum differentially signal the benefit...

journal_title：Neuron

authors： Reitich-Stolero T,Aberg KC,Paz R

更新日期：2019-08-07 00:00:00

abstract：:Carbon monoxide (CO) induces a long-lasting alteration in cerebellar alpha 3-Na,K-ATPase independent of [Na+] but linked to cGMP synthesis and localized to Purkinje neurons. The action of CO is absent in Purkinje neuron-deficient mice, mimicked by 8-Br-cGMP, and blocked by inhibition of PKG. Glutamate (Glu) and metabo...

journal_title：Neuron

authors： Nathanson JA,Scavone C,Scanlon C,McKee M

更新日期：1995-04-01 00:00:00

abstract：:Recent advances in military-funded neurotechnology and novel opportunities for misusing neurodevices show that the problem of dual use is inherent to neuroscience. This paper discusses how the neuroscience community should respond to these dilemmas and delineates a neuroscience-specific biosecurity framework. This neu...

journal_title：Neuron

authors： Ienca M,Jotterand F,Elger BS

更新日期：2018-01-17 00:00:00

abstract：:For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems. ...

journal_title：Neuron

authors： McAllister AK,van de Water J

更新日期：2009-10-15 00:00:00

abstract：:Nematode degenerins have been implicated in touch sensitivity and other forms of mechanosensation. Certain mutations in several degenerin genes cause the swelling, vacuolation, and death of neurons, and other mutations in the muscle degenerin gene unc-105 cause hypercontraction. Here, we confirm that unc-105 encodes a...

journal_title：Neuron

authors： García-Añoveros J,García JA,Liu JD,Corey DP

更新日期：1998-06-01 00:00:00

abstract：:In cultured rat embryonic septal nuclei with adjacent basal forebrain, murine interferon-gamma (IFN gamma) produces a striking increase in choline acetyltransferase (ChAT) activity and mRNA. The effect of IFN gamma on cholinergic differentiation is more potent in E14 cultures than in older cultures. IFN gamma does not...

journal_title：Neuron

authors： Jonakait GM,Wei R,Sheng ZL,Hart RP,Ni L

更新日期：1994-05-01 00:00:00

abstract：:Functionally distinct types of neurons develop in stereotypical positions in the vertebrate spinal cord. The mechanisms that generate this diversity have been well studied in the ventral and intermediate regions of the spinal cord, while dorsal cells have received less attention. In this issue of Neuron, two papers fo...

journal_title：Neuron

authors： Matise M

更新日期：2002-05-16 00:00:00

abstract：:The combination of patch-clamp and molecular biology techniques has made it possible to characterize the pharmacological and biophysical properties of ion channels in single neurons and to screen for expression of specific mRNAs in the same cell. Following whole-cell recording, the cytoplasm of the cell is harvested, ...

journal_title：Neuron

authors： Sucher NJ,Deitcher DL

更新日期：1995-06-01 00:00:00

abstract：:Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In contrast to these animal models, most human narcolepsy is not familial, is discordant in identical twins, and has not been linked to mutations of the Hcrt system. Thus, the cause of human narc...

journal_title：Neuron

authors： Thannickal TC,Moore RY,Nienhuis R,Ramanathan L,Gulyani S,Aldrich M,Cornford M,Siegel JM

更新日期：2000-09-01 00:00:00

abstract：:Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated. Here, we tested the multimodal capacity of peripheral first-order neurons, focusing on the genetically defined subpopu...

journal_title：Neuron

authors： Sharif B,Ase AR,Ribeiro-da-Silva A,Séguéla P

更新日期：2020-06-17 00:00:00

abstract：:Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holorece...

journal_title：Neuron

authors： Wang Q,Chiu SL,Koropouli E,Hong I,Mitchell S,Easwaran TP,Hamilton NR,Gustina AS,Zhu Q,Ginty DD,Huganir RL,Kolodkin AL

更新日期：2017-12-06 00:00:00

abstract：:The constant dynamic movement of synapses and their components has emerged in the last decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein movements drive conformation changes important to transduce transmitter binding into signaling. Constant cytoskeletal rearrangements power ...

journal_title：Neuron

authors： Choquet D,Triller A

更新日期：2013-10-30 00:00:00

abstract：:The chemokine Cxcl12 binds Cxcr4 and Cxcr7 receptors to control cell migration in multiple biological contexts, including brain development, leukocyte trafficking, and tumorigenesis. Both receptors are expressed in the CNS, but how they cooperate during migration has not been elucidated. Here, we used the migration of...

journal_title：Neuron

authors： Sánchez-Alcañiz JA,Haege S,Mueller W,Pla R,Mackay F,Schulz S,López-Bendito G,Stumm R,Marín O

更新日期：2011-01-13 00:00:00

abstract：:Critical periods are developmental time windows during which neuronal connections are shaped by experience. In this issue of Neuron, Davis et al. (2015) show that transplantation of embryonic inhibitory interneurons can reactivate critical period plasticity and reverse amblyopia in the visual cortex of adult mice. ...

journal_title：Neuron

authors： Levine JN,Gu Y,Cang J

更新日期：2015-05-20 00:00:00

abstract：:Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we investigate consequ...

journal_title：Neuron

authors： Judson MC,Wallace ML,Sidorov MS,Burette AC,Gu B,van Woerden GM,King IF,Han JE,Zylka MJ,Elgersma Y,Weinberg RJ,Philpot BD

更新日期：2016-04-06 00:00:00

abstract：:The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we exami...

journal_title：Neuron

authors： Smith AP,Stephan KE,Rugg MD,Dolan RJ

更新日期：2006-02-16 00:00:00

abstract：:The neural basis of spatial processing in the auditory cortex has been controversial. Human fMRI studies suggest that a part of the planum temporale (PT) is involved in auditory spatial processing, but it was recently argued that this region is active only when the task requires voluntary spatial localization. If this...

journal_title：Neuron

authors： Deouell LY,Heller AS,Malach R,D'Esposito M,Knight RT

更新日期：2007-09-20 00:00:00

abstract：:Recent progress in neurophysiological recording has developed in two directions. One relies on multimicroelectrodes to study correlations in neuron firing. The other relies on sophisticated tasks to distinguish successive stages of neuronal processing. In this issue of Neuron, Shichinohe et al. take this second approa...

journal_title：Neuron

authors： Schlag JD,Schlag-Rey M

更新日期：2009-06-11 00:00:00

abstract：:Spontaneous fMRI fluctuations are organized in large-scale spatiotemporal structures, or resting-state networks (RSN). However, it is unknown how task performance affects RSN dynamics. We use MEG to measure slow (∼0.1 Hz) coherent fluctuations of band-limited power (BLP), a robust correlate of RSN, during rest and mov...

journal_title：Neuron

authors： Betti V,Della Penna S,de Pasquale F,Mantini D,Marzetti L,Romani GL,Corbetta M

更新日期：2013-08-21 00:00:00

abstract：:Using a novel visual-tactile paradigm in rats, Nikbakht et al. (2018) describe multisensory behavior that outperformed predictions of optimal cue combination (indicating cross-modal synergy) and exposed encoding in PPC neurons (of stimulus and choice signals) that was independent of stimulus modality. ...

journal_title：Neuron

authors： Shalom S,Zaidel A

更新日期：2018-02-07 00:00:00

abstract：:Two articles in this issue of Neuron (Eichner et al. and Clark et al.) attack the problem of explaining how neuronal hardware in Drosophila implements the Reichardt motion detector, one of the most famous computational models in neuroscience, which has proven intractable up to now. ...

journal_title：Neuron

authors： Gabbiani F,Jones PW

更新日期：2011-06-23 00:00:00

abstract：:The Fragile X mental retardation protein (FMRP) regulates neuronal RNA metabolism, and its absence or mutations leads to the Fragile X syndrome (FXS). The β-amyloid precursor protein (APP) is involved in Alzheimer's disease, plays a role in synapse formation, and is upregulated in intellectual disabilities. Here, we s...

journal_title：Neuron

authors： Pasciuto E,Ahmed T,Wahle T,Gardoni F,D'Andrea L,Pacini L,Jacquemont S,Tassone F,Balschun D,Dotti CG,Callaerts-Vegh Z,D'Hooge R,Müller UC,Di Luca M,De Strooper B,Bagni C

更新日期：2015-07-15 00:00:00

abstract：:Axon bifurcation results in the formation of sister branches, and divergent segregation of the sister branches is essential for efficient innervation of multiple targets. From a genetic mosaic screen, we find that a lethal mutation in the Drosophila Down syndrome cell adhesion molecule (Dscam) specifically perturbs se...

journal_title：Neuron

authors： Wang J,Zugates CT,Liang IH,Lee CH,Lee T

更新日期：2002-02-14 00:00:00

abstract：:Circadian clock proteins are modified in many different ways. The best-studied posttranslational modification is phosphorylation, with well-known kinases and phosphatases regulating the function and stability of clock proteins. Degradation of these proteins usually involves ubiquitylation or sumoylation, and some of t...

journal_title：Neuron

authors： Sehgal A

更新日期：2008-01-10 00:00:00

abstract：:Neuronal population responses can vary across trials as a result of differences in the relative timing of internal brain processes. In this issue of Neuron, Williams et al. (2020) present an algorithm for inferring and inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal st...

journal_title：Neuron

authors： Okun M

更新日期：2020-01-22 00:00:00

abstract：:Regulation of synaptic strength is essential for neuronal information processing, but the molecular mechanisms that control changes in neuroexocytosis are only partially known. Here we show that the putative G protein-coupled receptor Methuselah (Mth) is required in the presynaptic motor neuron to acutely upregulate n...

journal_title：Neuron

authors： Song W,Ranjan R,Dawson-Scully K,Bronk P,Marin L,Seroude L,Lin YJ,Nie Z,Atwood HL,Benzer S,Zinsmaier KE

更新日期：2002-09-26 00:00:00

abstract：:We examined context-dependent encoding of speech in children with and without developmental dyslexia by measuring auditory brainstem responses to a speech syllable presented in a repetitive or variable context. Typically developing children showed enhanced brainstem representation of features related to voice pitch in...

journal_title：Neuron

authors： Chandrasekaran B,Hornickel J,Skoe E,Nicol T,Kraus N

更新日期：2009-11-12 00:00:00

abstract：:Mesolimbic dopamine (DA) neurons play a central role in motivation and reward processing. Although the activity of these mesolimbic DA neurons is controlled by afferent inputs, little is known about the circuits in which they are embedded. Using retrograde tracing, electrophysiology, optogenetics, and behavioral assay...

journal_title：Neuron

authors： Yang H,de Jong JW,Tak Y,Peck J,Bateup HS,Lammel S

更新日期：2018-01-17 00:00:00

abstract：:The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene. BDNF was the major survival factor for vestibular ganglion neurons, and NT-3, for spiral ganglion neurons. Lack of BDNF and NT-3 did not affect ingrowth...

journal_title：Neuron

authors： Ernfors P,Van De Water T,Loring J,Jaenisch R

更新日期：1995-06-01 00:00:00