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Presynaptic regulation of neurotransmission in Drosophila by the g protein-coupled receptor methuselah.

Abstract：

:Regulation of synaptic strength is essential for neuronal information processing, but the molecular mechanisms that control changes in neuroexocytosis are only partially known. Here we show that the putative G protein-coupled receptor Methuselah (Mth) is required in the presynaptic motor neuron to acutely upregulate neurotransmitter exocytosis at larval Drosophila NMJs. Mutations in the mth gene reduce evoked neurotransmitter release by approximately 50%, and decrease synaptic area and the density of docked and clustered vesicles. Pre- but not postsynaptic expression of normal Mth restored normal release in mth mutants. Conditional expression of Mth restored normal release and normal vesicle docking and clustering but not the reduced size of synaptic sites, suggesting that Mth acutely adjusts vesicle trafficking to synaptic sites.

journal_name

Neuron

journal_title

Neuron

authors

Song W,Ranjan R,Dawson-Scully K,Bronk P,Marin L,Seroude L,Lin YJ,Nie Z,Atwood HL,Benzer S,Zinsmaier KE

doi

10.1016/s0896-6273(02)00932-7

subject

Has Abstract

pub_date

2002-09-26 00:00:00

pages

105-19

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896627302009327

journal_volume

36

pub_type

杂志文章

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